Growth Response, Pubertal Growth and Final Height in Greek Children with Growth Hormone (GH) Deficiency on Long-term GH Therapy and Factors Affecting Outcome

2001 ◽  
Vol 14 (4) ◽  
Author(s):  
K. Karavanaki ◽  
C. Kontaxaki ◽  
M. Maniati-Christidi ◽  
V.Petrou ◽  
C. Dacou-Voutetakis
Keyword(s):  
Growth Hormone ◽  
Growth Response ◽  
Gh Deficiency ◽  
Final Height ◽  
Gh Therapy ◽  
Factors Affecting ◽  
Pubertal Growth

Short- and Long-Term (Final Height) Growth Responses to Growth Hormone (GH) Therapy in Patients with Turner Syndrome: Correlation of Growth Response to Stimulated GH Levels, Spontaneous GH Secretion, and Karyotype

1997 ◽  
Vol 47 (2) ◽  
pp. 67-72 ◽  
Author(s):  
Klaus Schmitt ◽  
Gabriele Haeusler ◽  
Peter Blümel ◽  
Engelbert Plöchl ◽  
Herwig Frisch
Keyword(s):  
Growth Hormone ◽  
Turner Syndrome ◽  
Growth Response ◽  
Final Height ◽  
Height Growth ◽  
Growth Responses ◽  
Gh Therapy ◽  
Gh Secretion ◽  
Short And Long Term

scholarly journals Growth Hormone (GH) Receptor C.1319 G>T Polymorphism, But Not Exon 3 Retention or Deletion Is Associated With Better First-Year Growth Response to GH Therapy in Patients With GH Deficiency

2007 ◽  
Vol 62 (6) ◽  
pp. 735-740 ◽  
Author(s):  
Lei Wan ◽  
Wei-Cheng Chen ◽  
Yuhsin Tsai ◽  
Yu-Tsun Kao ◽  
Yao-Yuan Hsieh ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Response ◽  
Gh Deficiency ◽  
First Year ◽  
Gh Therapy ◽  
Gh Receptor

scholarly journals Growth Hormone (GH) Pharmacogenetics: Influence of GH Receptor Exon 3 Retention or Deletion on First-Year Growth Response and Final Height in Patients with Severe GH Deficiency

2006 ◽  
Vol 91 (3) ◽  
pp. 1076-1080 ◽  
Author(s):  
Alexander A. L. Jorge ◽  
Frederico G. Marchisotti ◽  
Luciana R. Montenegro ◽  
Luciani R. Carvalho ◽  
Berenice B. Mendonca ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Response ◽  
Gh Deficiency ◽  
Final Height ◽  
First Year ◽  
Gh Receptor

scholarly journals Inclusion and Withdrawal Criteria for Growth Hormone (GH) Therapy in Children with Idiopathic GH Deficiency—Towards Following the Evidence but Still with Unresolved Problems

2022 ◽  
Author(s):  
Joanna Smyczyńska
Keyword(s):  
Growth Hormone ◽  
Gh Deficiency ◽  
Final Height ◽  
Threshold Value ◽  
Reference Ranges ◽  
Gh Therapy ◽  
Gh Secretion ◽  
Accelerate Growth ◽  
Stimulation Tests ◽  
Definition Of

According to current guidelines, growth hormone (GH) therapy is strongly recommended in children and adolescents with GH deficiency (GHD) in order to accelerate growth rate and attain normal adult height. The diagnosis of GHD requires demonstration of decreased GH secretion in stimulation tests, below the established threshold value. Currently, GHD in children is classified as secondary insulin-like growth factor-1 (IGF-1) deficiency. Most of children diagnosed with isolated GHD presents with normal GH secretion at the attainment of near-final height or even in mid-puberty. The most important clinical problems, related to the diagnosis of isolated GHD in children and to optimal duration of rhGH therapy include: arbitrary definition of subnormal GH peak in stimulation tests, disregarding factors influencing GH secretion, insufficient diagnostic accuracy and poor reproducibility of GH stimulation tests, discrepancies between spontaneous and stimulated GH secretion, clinical entity of neurosecretory dysfunction, discrepancies between IGF-1 concentrations and results of GH stimulation tests, significance of IGF-1 deficiency for the diagnosis of GHD, a need for validation IGF-1 reference ranges. Many of these issues have remained unresolved for 25 years or even longer. It seems that finding solutions to them should optimize diagnostics and therapy of children with short stature.

Response to growth hormone treatment in very young patients with growth hormone deficiencies and mini-puberty

2018 ◽  
Vol 31 (2) ◽  
pp. 175-184 ◽  
Author(s):  
Semra Çetinkaya ◽  
Şükran Poyrazoğlu ◽  
Firdevs Baş ◽  
Oya Ercan ◽  
Metin Yıldız ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Weight Gain ◽  
Growth Response ◽  
Gh Deficiency ◽  
Young Patients ◽  
First Year ◽  
Gh Treatment ◽  
Factors Affecting ◽  
Second Year ◽  
Length Gain

Abstract Background: The aim of the study was to assess the response to growth hormone (GH) treatment in very young patients with GH deficiency (GHD) through a national, multi-center study. Possible factors affecting growth response were assessed (especially mini-puberty). Methods: Medical reports of GHD patients in whom treatment was initiated between 0 and 3 years of age were retrospectively evaluated. Results: The cohort numbered 67. The diagnosis age was 12.4±8.6 months, peak GH stimulation test response (at diagnosis) as 1.0±1.4 ng/mL. The first and second years length gain was 15.0±4.3 and 10.4±3.4 cm. Weight gain had the largest effect on first year growth response; whereas weight gain and GH dose were both important factors affecting second year growth response. In the multiple pituitary hormone deficiency (MPHD) group (n=50), first year GH response was significantly greater than in the isolated GH deficiency (IGHD) group (n=17) (p=0.030). In addition first year growth response of infants starting GH between 0 and 12 months of age (n=24) was significantly greater than those who started treatment between 12 and 36 months of age (n=43) (p<0.001). These differences were not seen in the second year. Δ Length/height standard deviation score (SDS), Δ body weight SDS, length/height SDS, weight SDS in MPHD without hypogonadism for the first year of the GH treatment were found as significantly better than MPHD with hypogonadism. Conclusions: Early onsets of GH treatment, good weight gain in the first year of the treatment and good weight gain-GH dose in the second year of the treatment are the factors that have the greatest effect on length gain in early onset GHD. The presence of the sex steroid hormones during minipubertal period influence growth pattern positively under GH treatment (closer to the normal percentage according to age and gender).

scholarly journals 24 GROWTH RESPONSE TO GROWTH HORMONE(GH) THERAPY IN PREPUBERTAL CHILDREN WITH PARTIAL AND TOTAL GH DEFICIENCY

1985 ◽  
Vol 19 (6) ◽  
pp. 607-607
Author(s):  
Jan-Maarten Wit ◽  
J Leo Van Den Brande
Keyword(s):  
Growth Hormone ◽  
Growth Response ◽  
Gh Deficiency ◽  
Gh Therapy ◽  
Prepubertal Children

scholarly journals FINAL HEIGHT IN 22 PATIENTS WITH IDIOPATHIC GROWTH HORMONE (GH) DEFICIENCY AFTER LONG TERM TREATMENT WITH GH

1986 ◽  
Vol 20 (11) ◽  
pp. 1187-1187 ◽  
Author(s):  
H Frisch ◽  
E Schober ◽  
F Waldhauser
Keyword(s):  
Growth Hormone ◽  
Gh Deficiency ◽  
Final Height ◽  
Term Treatment ◽  
Long Term Treatment
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