scholarly journals Growth Hormone (GH) Receptor C.1319 G>T Polymorphism, But Not Exon 3 Retention or Deletion Is Associated With Better First-Year Growth Response to GH Therapy in Patients With GH Deficiency

2007 ◽  
Vol 62 (6) ◽  
pp. 735-740 ◽  
Author(s):  
Lei Wan ◽  
Wei-Cheng Chen ◽  
Yuhsin Tsai ◽  
Yu-Tsun Kao ◽  
Yao-Yuan Hsieh ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Response ◽  
Gh Deficiency ◽  
First Year ◽  
Gh Therapy ◽  
Gh Receptor

scholarly journals Growth Hormone (GH) Pharmacogenetics: Influence of GH Receptor Exon 3 Retention or Deletion on First-Year Growth Response and Final Height in Patients with Severe GH Deficiency

2006 ◽  
Vol 91 (3) ◽  
pp. 1076-1080 ◽  
Author(s):  
Alexander A. L. Jorge ◽  
Frederico G. Marchisotti ◽  
Luciana R. Montenegro ◽  
Luciani R. Carvalho ◽  
Berenice B. Mendonca ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Response ◽  
Gh Deficiency ◽  
Final Height ◽  
First Year ◽  
Gh Receptor

scholarly journals Growth Hormone (GH) Dose, But Not Exon 3-Deleted/Full-Length GH Receptor Polymorphism Genotypes, Influences Growth Response to Two-Year GH Therapy in Short Small-for-Gestational-Age Children

2008 ◽  
Vol 93 (1) ◽  
pp. 147-153 ◽  
Author(s):  
Antonio Carrascosa ◽  
Laura Audí ◽  
Cristina Esteban ◽  
Mónica Fernández-Cancio ◽  
Pilar Andaluz ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Growth Response ◽  
Full Length ◽  
Gh Therapy ◽  
Gh Receptor ◽  
Receptor Polymorphism

Growth Response, Pubertal Growth and Final Height in Greek Children with Growth Hormone (GH) Deficiency on Long-term GH Therapy and Factors Affecting Outcome

2001 ◽  
Vol 14 (4) ◽  
Author(s):  
K. Karavanaki ◽  
C. Kontaxaki ◽  
M. Maniati-Christidi ◽  
V.Petrou ◽  
C. Dacou-Voutetakis
Keyword(s):  
Growth Hormone ◽  
Growth Response ◽  
Gh Deficiency ◽  
Final Height ◽  
Gh Therapy ◽  
Factors Affecting ◽  
Pubertal Growth

Response to growth hormone treatment in very young patients with growth hormone deficiencies and mini-puberty

2018 ◽  
Vol 31 (2) ◽  
pp. 175-184 ◽  
Author(s):  
Semra Çetinkaya ◽  
Şükran Poyrazoğlu ◽  
Firdevs Baş ◽  
Oya Ercan ◽  
Metin Yıldız ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Weight Gain ◽  
Growth Response ◽  
Gh Deficiency ◽  
Young Patients ◽  
First Year ◽  
Gh Treatment ◽  
Factors Affecting ◽  
Second Year ◽  
Length Gain

Abstract Background: The aim of the study was to assess the response to growth hormone (GH) treatment in very young patients with GH deficiency (GHD) through a national, multi-center study. Possible factors affecting growth response were assessed (especially mini-puberty). Methods: Medical reports of GHD patients in whom treatment was initiated between 0 and 3 years of age were retrospectively evaluated. Results: The cohort numbered 67. The diagnosis age was 12.4±8.6 months, peak GH stimulation test response (at diagnosis) as 1.0±1.4 ng/mL. The first and second years length gain was 15.0±4.3 and 10.4±3.4 cm. Weight gain had the largest effect on first year growth response; whereas weight gain and GH dose were both important factors affecting second year growth response. In the multiple pituitary hormone deficiency (MPHD) group (n=50), first year GH response was significantly greater than in the isolated GH deficiency (IGHD) group (n=17) (p=0.030). In addition first year growth response of infants starting GH between 0 and 12 months of age (n=24) was significantly greater than those who started treatment between 12 and 36 months of age (n=43) (p<0.001). These differences were not seen in the second year. Δ Length/height standard deviation score (SDS), Δ body weight SDS, length/height SDS, weight SDS in MPHD without hypogonadism for the first year of the GH treatment were found as significantly better than MPHD with hypogonadism. Conclusions: Early onsets of GH treatment, good weight gain in the first year of the treatment and good weight gain-GH dose in the second year of the treatment are the factors that have the greatest effect on length gain in early onset GHD. The presence of the sex steroid hormones during minipubertal period influence growth pattern positively under GH treatment (closer to the normal percentage according to age and gender).

scholarly journals 24 GROWTH RESPONSE TO GROWTH HORMONE(GH) THERAPY IN PREPUBERTAL CHILDREN WITH PARTIAL AND TOTAL GH DEFICIENCY

1985 ◽  
Vol 19 (6) ◽  
pp. 607-607
Author(s):  
Jan-Maarten Wit ◽  
J Leo Van Den Brande
Keyword(s):  
Growth Hormone ◽  
Growth Response ◽  
Gh Deficiency ◽  
Gh Therapy ◽  
Prepubertal Children

Growth response to growth hormone treatment in patients with SHOX deficiency can be predicted by the Cologne prediction model

2018 ◽  
Vol 31 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Heike Hoyer-Kuhn ◽  
Jeremy Franklin ◽  
Christine Jones ◽  
Werner F. Blum ◽  
Eckhard Schoenau
Keyword(s):  
Growth Hormone ◽  
Root Mean Square Error ◽  
Prediction Model ◽  
Mean Square Error ◽  
Growth Response ◽  
Gh Deficiency ◽  
Pearson Correlation ◽  
First Year ◽  
Pearson Correlation Coefficient ◽  
Mean Square

AbstractBackgroundGrowth hormone (GH) treatment in children with short stature homeobox-containing gene (SHOX) deficiency is recognized to increase height velocity (HV) and adult height. Prediction of growth response continues to be a challenge. A comparatively accurate method is the Cologne prediction model developed in children with GH deficiency. The aim was to investigate whether this model also applies to patients with SHOX deficiency.MethodsIncluded were 48 patients with SHOX deficiency confirmed by DNA analysis and treated with 0.05 mg/kg/day of somatropin. Prediction by the Cologne model uses the following variables: relative bone age (BA) retardation, baseline insulin-like growth factor-I (IGF-I), urinary deoxypyridinoline (DPD) cross-links at 4 weeks and HV at 3 months.ResultsHV and height standard deviation scores (SDS) increased significantly during the first year of treatment. Predicted and observed HV (cm/year) showed a Pearson correlation coefficient of 0.50 (p<0.001; root-mean-square error=1.63) and for first-year change in height SDS a Pearson correlation coefficient of 0.751 (p<0.001; root-mean-square error=0.32). Poor response could be adequately predicted using SDS change, with sensitivity and specificity both above 70% for certain thresholds.Conclusions:The results demonstrate that the Cologne model can be used to predict growth response in patients with SHOX deficiency with reasonable precision in the first treatment year, comparable to prediction in patients with GH deficiency.

scholarly journals Comparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency

2014 ◽  
Vol 58 (1) ◽  
pp. 23-29 ◽  
Author(s):  
Daniela F. Cardoso ◽  
Carlos Eduardo Martinelli Jr. ◽  
Viviane C. Campos ◽  
Elenilde S. Gomes ◽  
Ívina E. S. Rocha ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Gh Deficiency ◽  
Care Service ◽  
Standard Deviation Score ◽  
Laboratory Data ◽  
First Year ◽  
Gh Therapy ◽  
Public Care ◽  
Initial Height ◽  
One Year

Objectives: GH therapy is still controversial, except in severe GH deficiency (SGHD). The objective of this study was to compare the response to growth hormone (GH) therapy in children with partial GH insensitivity (PGHIS) and mild GH deficiency (MGHD) with those with SGHD.Subjects and methods: Fifteen PGHIS, 11 MGHD, and 19 SGHD subjects, followed up for more than one year in the Brazilian public care service, were evaluated regarding anthropometric and laboratory data at the beginning of treatment, after one year (1 st year) on treatment, and at the last assessment (up to ten years in SGHD, up to four years in MGHD, and up to eight years in PGHIS).Results: Initial height standard deviation score (SDS) in SGHD was lower than in MGHD and PGHIS. Although the increase in 1 st year height SDS in comparison to initial height SDS was not different among the groups, height-SDS after the first year of treatment remained lower in SGHD than in MGHD. There was no difference in height-SDS at the last assessment of the children among the three groups. GH therapy, in the entire period of observation, caused a trend towards lower increase in height SDS in PGHIS than SGHD but similar increases were observed in MGHD and SGHD.Conclusion: GH therapy increases height in PGHIS and produces similar height effects in MGHD and SGHD.

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