scholarly journals Differences in complications between hepatitis B-related cirrhosis and alcohol-related cirrhosis

Open Medicine ◽  
2021 ◽  
Vol 17 (1) ◽  
pp. 46-52
Author(s):  
Yu-Pei Zhuang ◽  
Si-Qi Wang ◽  
Zhao-Yu Pan ◽  
Hao-Jie Zhong ◽  
Xing-Xiang He
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatic Encephalopathy ◽  
Hepatitis B ◽  
Medical Records ◽  
Odds Ratio ◽  
Chronic Liver Failure ◽  
Adjusted Risk ◽  
B Virus ◽  
Different Types ◽  
Cirrhotic Patients

Abstract Objectives This study aimed to investigate the differences in complications between hepatitis B virus (HBV)-related and alcohol-related cirrhoses. Methods Medical records of patients with HBV-related and alcohol-related cirrhoses treated from January 2014 to January 2021 were, retrospectively, reviewed. The unadjusted rate and adjusted risk of cirrhotic complications between the two groups were assessed. Results The rates of hepatocellular carcinoma (HCC) and hypersplenism were higher in HBV-related cirrhosis (both P < 0.05), whereas the rates of hepatic encephalopathy (HE) and acute-on-chronic liver failure (ACLF) were higher in alcohol-related cirrhosis (both P < 0.05). After adjusting for potential confounders, HBV-related cirrhotic patients had higher risks of HCC (odds ratio [OR] = 34.06, 95% confidence interval [CI]: 4.61–251.77, P = 0.001) and hypersplenism (OR = 2.29, 95% CI: 1.18–4.42, P = 0.014), whereas alcohol-related cirrhotic patients had higher risks of HE (OR = 0.22, 95% CI: 0.06–0.73, P = 0.013) and ACLF (OR = 0.30, 95% CI: 0.14–0.73, P = 0.020). Conclusion Cirrhotic patients with different etiologies had different types of complications: HBV-related cirrhotic patients exhibited increased risks of HCC and hypersplenism and alcohol-related cirrhotic patients more readily developing HE and ACLF.

scholarly journals Hiv And Hepatitis B Virus Co-Infection

2021 ◽  
Vol 9 (9) ◽  
pp. 99-109
Author(s):  
Leandro Júnior de Lima ◽  
Ana Lúcia Lyrio de Oliveira ◽  
Valdir Aragão Nascimento ◽  
Josiel Elisandro Werle ◽  
Priscila G. S. dos Santos ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Hepatitis B ◽  
Risky Sexual Behavior ◽  
Medical Records ◽  
Clinical Importance ◽  
Secondary Data ◽  
Multiple Sexual Partners ◽  
B Virus

The clinical importance of HBV-HIV co-infection comes from the fact that both viruses are highly transmissible and share similar routes of transmission. Co-infected individuals are more likely to develop liver cirrhosis and hepatocellular carcinoma. In view of the above, this manuscript is a quantitative, sectional, descriptive study with secondary data obtained from the analysis of medical records of 88 individuals with chronic hepatitis B. Thus, the purpose of this manuscript is to estimate the frequency of HBV-HIV co-infection and to identify the presence of liver damage. The results revealed an HBV-HIV co-infection rate of 9.1% (8//88), with two individuals being infected with the HIV-HBV-HCV virus concurrently. A large percentage of patients are male and heterosexual. There was a relationship between risky sexual behavior (sex without using a condom, multiple sexual partners) and the acquisition of hepatitis B and HIV. Related to the presence of liver lesions, it was observed that only one patient is diagnosed with liver cirrhosis, but there were no cases of hepatocellular carcinoma. Considering the increase in the quality of life and survival of people with HIV, the need to maintain protocols for the investigation of hepatocellular carcinoma is evident, thus seeking early detection and treatment.

Incidence and significance of hepatitis B e antigen and antibody in postnecrotic cirrhosis and primary hepatocellular carcinoma

1978 ◽  
Vol 7 (4) ◽  
pp. 394-395
Author(s):  
P Coursaget ◽  
P Maupas ◽  
A Goudeau ◽  
J Drucker
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B ◽  
Blood Donors ◽  
Primary Hepatocellular Carcinoma ◽  
Control Group ◽  
Serological Markers ◽  
Hepatitis B E Antigen ◽  
B Virus ◽  
Postnecrotic Cirrhosis ◽  
Cirrhotic Patients

A study of the serological markers of Hepatitis B virus (HBV) including e antigen (HBe Ag) and antibody against HBe Ag (anti-HBe) was performed in Senegalese patients suffering from cirrhosis and primary hepatocellular carcinoma, and in a control group (blood donors). It was not possible to diagnose additional HBV infections in primary hepatocellular carcinoma patients using HBe Ag or anti-HBe Ab alone as serological markers. The lower prevalence of HBe Ag among primary hepatocellular carcinoma patients as compared with cirrhotic patients suggests that active replication of HBV becomes increasingly defective during the course of the malignant process.

Sa1513 THE RISK OF HEPATOCELLULAR CARCINOMA IN NON-CIRRHOTIC PATIENTS WITH HEPATITIS B VIRUS INFECTION

2020 ◽  
Vol 158 (6) ◽  
pp. S-1316-S-1317
Author(s):  
Muhammad Talal Sarmini ◽  
Kanokwan Pinyopornpanish ◽  
Brittany Mitchell ◽  
Hamna Fahad ◽  
Arthur McCullough
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Hepatitis B Virus Infection ◽  
B Virus ◽  
Cirrhotic Patients

scholarly journals Nucleotide changes related to hepatocellular carcinoma in the enhancer 1/x-promoter of hepatitis B virus subgenotype C2 in cirrhotic patients

2010 ◽  
Vol 101 (8) ◽  
pp. 1905-1912 ◽  
Author(s):  
Eun-Young Cho ◽  
Haak-Cheoul Kim ◽  
Chang-Soo Choi ◽  
Sae Ron Shin ◽  
Channy Park ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
B Virus ◽  
Cirrhotic Patients

scholarly journals Long-Term Prognosis of Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failure: A Retrospective Study

2021 ◽  
Author(s):  
Lu Wang ◽  
Wenxiong Xu ◽  
Xuejun Li ◽  
Dabiao Chen ◽  
Yeqiong Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Antiviral Treatment ◽  
Chronic Liver Failure ◽  
Short Term ◽  
B Virus ◽  
Cirrhotic Patients ◽  
Long Term Prognosis

Abstract Introduction and Objectives: The long-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is not well characterized. We sought to assess the short-term and long-term outcomes and the associated risk factors of HBV-ACLF patients in south China.Patients and Methods: We retrospectively analyzed clinical data, adverse events, and clinical endpoint events of HBV-ACLF patients treated at our department between January 2014 and December 2018. Results: A total of 1177 HBV-ACLF patients were included in the study, including 616 (52.3%) cirrhotic patients and 561 (47.7%) non-cirrhotic patients. 973 (83%) patients were associated only with HBV, and 204 (17%) patients had two or more etiologies. The leading cause of simple HBV-ACLF patients was lack of antiviral treatment and the proportion of patients receiving antiviral treatment for HBV was low (20%). Further analyses indicated non-cirrhotic patients had a significantly lower 90-day transplantation‐free mortality and greater 5‐year survival rate than cirrhotic patients (59.5% vs. 27.6%, 62% vs. 36%, P＜0.05). Age, hepatic encephalopathy, liver cirrhosis, nucleoside (acid) analogues (NAs) withdrawal, total bilirubin, and prothrombin time were independent risk factors for 90-day mortality in HBV-ACLF patients. Cirrhosis at admission (AOR=3.675, 95% CI: 2.408–6.594) was a strong independent risk factor for long-term prognosis. Conclusion: The proportion of HBV-ACLF patients receiving antiviral treatment was extremely low in south China. HBV combined with acute hepatitis E, or DILI had no significant effect on the short-term mortality rate in HBV-ACLF patients. Remarkably, the effect of withdrawal of NAs and cirrhosis on short-term outcomes cannot be ignored. No significant improvement in the short-term prognosis of HBV-ACLF patients was observed compared with previous studies. Trial Registration: The trial is registered at ClinicalTrials.gov (CT.gov identifier: NCT04231565). Registered 13 May 2020https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S0009OZY&selectaction=Edit&uid=U00036P1&ts=2&cx=27seqt

Role of environmental factors in the etiology of hepatocellular carcinoma

2010 ◽  
Vol 151 (28) ◽  
pp. 1132-1136 ◽  
Author(s):  
István Tornai
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Environmental Factors ◽  
Hepatitis B ◽  
Hepatitis A ◽  
Virus Hepatitis ◽  
B Virus

A krónikus vírushepatitisek jelentik ma a legismertebb okokat a hepatocellularis carcinoma (HCC) kialakulásában. A krónikus B- és C-vírus-hepatitis a májrákok körülbelül 40-50%-át okozza. A nyugati típusú társadalmakban a HCC előfordulása folyamatosan növekvő tendenciát mutat. Az alkohol számít a környezeti tényezők közül a legfontosabbnak, bár az alkoholfogyasztás a legtöbb országban csökken. Ez aláhúzza az egyéb környezeti tényezők fontosságát is. Az elfogyasztott alkoholmennyiséggel egyenes arányban növekszik a cirrhosis és a következményes HCC gyakorisága nőkben és férfiakban egyaránt. A kémiai anyagok közül a legismertebb a Kínában és Afrikában elterjedt aflatoxin, amely a gabonaféléket szennyező mycotoxin. Hasonló területeken endémiás, mint a hepatitis B-vírus, együtt szinergista hatást fejtenek ki. A dohányzás is egyértelműen bizonyított hepatocarcinogen hatással rendelkezik. Ez is jelentősen fokozódik, ha alkoholfogyasztással vagy vírushepatitisszel társul. Társadalmilag talán a legfontosabb az elhízás, a következményes nem alkoholos zsírmáj, illetve steatohepatitis és a 2-es típusú cukorbetegség, amelyek prevalenciája egyre fokozódik. Feltehetően ezek állnak a növekvő HCC-gyakoriság hátterében. Az inzulinrezisztencia és az oxidatív stressz képezik a legfontosabb patogenetikai lépéseket a májsejtkárosodásban. További fontos rizikótényező az orális fogamzásgátlók elterjedt használata. Egyes foglalkozások esetén a tartós szervesoldószer-expozíció is növeli a HCC rizikóját. Védelmet jelenthetnek az antioxidánsok, a szelén, a gyógyszerek közül a statinok és a feketekávé-fogyasztás.

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