Does diabetes affect paraneoplastic thrombocytosis in colorectal cancer?

Abstract Background A large variety of factors can affect colorectal cancer (CRC) survival, including type 2 diabetes mellitus (T2DM) and paraneoplastic thrombocytosis. Although several common factors play a role in their development and platelets are damaged in both diseases, the combined relationship of the three conditions was never investigated previously. Methods A prospective, real-life observational cohort study was conducted with the inclusion of 108 CRC patients and 166 voluntary non-CRC subjects. Plasma interleukin-6 and thrombopoietin levels were measured. Results Study participants were divided into cohorts based on the presence of T2DM. Platelet count (p < 0.0500) and interleukin-6 (p < 0.0100) level were significantly higher in the CRC groups. Thrombopoietin level was higher in the T2DM, CRC, and CRC + T2DM groups (p < 0.0500). Analysis of parameter changes over time and survival models revealed that neither platelet count, interleukin-6, nor thrombopoietin levels were affected by T2DM. Death of patients was associated with higher baseline platelet count (p = 0.0042) and interleukin-6 level (p < 0.0001). Conclusion Although the independent, disease-worsening effect of paraneoplastic thrombocytosis and T2DM is known, the coexistence of the two did not further impair the survival of CRC patients, suggesting that T2DM has no significant effect over paraneoplastic thrombocytosis.

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Real-life multidisciplinary treatment for unresectable colorectal cancer liver metastases including hepatic artery infusion with chemo-filtration and liquid biopsy precision oncotherapy: observational cohort study

Journal of Cancer Research and Clinical Oncology ◽

10.1007/s00432-020-03156-3 ◽

2020 ◽

Vol 146 (5) ◽

pp. 1273-1290 ◽

Cited By ~ 3

Author(s):

Stefano Guadagni ◽

Marco Clementi ◽

Andrew R. Mackay ◽

Enrico Ricevuto ◽

Giammaria Fiorentini ◽

...

Keyword(s):

Colorectal Cancer ◽

Cohort Study ◽

Liver Metastases ◽

Liquid Biopsy ◽

Multidisciplinary Treatment ◽

Real Life ◽

Observational Cohort Study ◽

Hepatic Artery Infusion ◽

Colorectal Cancer Liver Metastases ◽

Observational Cohort

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Coffee Consumption and the Incidence of Colorectal Cancer in Women

Journal of Cancer Epidemiology ◽

10.1155/2016/6918431 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8 ◽

Cited By ~ 7

Author(s):

Erik J. Groessl ◽

Matthew A. Allison ◽

Joseph C. Larson ◽

Samuel B. Ho ◽

Linda G. Snetslaar ◽

...

Keyword(s):

Colorectal Cancer ◽

Proportional Hazards ◽

Coffee Consumption ◽

Coffee Intake ◽

Observational Cohort ◽

Colorectal Cancer Incidence ◽

Meta Analyses ◽

Relationship Of ◽

The Relationship

Background.Higher coffee consumption has been associated with decreased incidence of colorectal cancer. Our objective was to examine the relationship of coffee intake to colorectal cancer incidence in a large observational cohort of postmenopausal US women.Methods.Data were collected for the Women’s Health Initiative Observational Study providing a follow-up period of 12.9 years. The mean age of our sample (N=83,778 women) was 63.5 years. Daily coffee intake was grouped into 3 categories: None, moderate (>0–<4 cups), and high (4+ cups). Proportional hazards modeling was used to evaluate the relationship between coffee intake and colorectal cancer.Results.There were 1,282 (1.53%) new cases of colorectal cancer during follow-up. Compared to nondrinkers, moderate and high coffee drinkers had an increased incidence of colorectal cancer in multivariate analysis (HR 1.15, 1.02–1.29; HR 1.14, 0.93–1.38). Moderate drip brew coffee intake (HR 1.20, 1.05–1.36) and high nondrip brew coffee intake (HR 1.43, 1.01–2.02) were associated with increased odds.Conclusion.Our results suggesting increased incidence of colorectal cancer associated with higher coffee consumption contradict recent meta-analyses but agree with a number of other studies showing that coffee increases risk or has no effect. Brew method results are novel and warrant further research.

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