scholarly journals A surface acoustic wave-driven micropump for particle uptake investigation under physiological flow conditions in very small volumes

nano Online ◽  
2016 ◽  
Author(s):  
Florian Strobl ◽  
Dominik Breyer ◽  
Phillip Link ◽  
Adriano Torrano ◽  
Christoph Bräuchle ◽  
...  
2015 ◽  
Vol 6 ◽  
pp. 414-419 ◽  
Author(s):  
Florian G Strobl ◽  
Dominik Breyer ◽  
Phillip Link ◽  
Adriano A Torrano ◽  
Christoph Bräuchle ◽  
...  

Static conditions represent an important shortcoming of many in vitro experiments on the cellular uptake of nanoparticles. Here, we present a versatile microfluidic device based on acoustic streaming induced by surface acoustic waves (SAWs). The device offers a convenient method for introducing fluid motion in standard cell culture chambers and for mimicking capillary blood flow. We show that shear rates over the whole physiological range in sample volumes as small as 200 μL can be achieved. A precise characterization method for the induced flow profile is presented and the influence of flow on the uptake of Pt-decorated CeO2 particles by endothelial cells (HMEC-1) is demonstrated. Under physiological flow conditions the particle uptake rates for this system are significantly lower than at low shear conditions. This underlines the vital importance of the fluidic environment for cellular uptake mechanisms.


1981 ◽  
Vol 42 (C4) ◽  
pp. C4-365-C4-368
Author(s):  
K. L. Bhatia ◽  
M.v. Haumeder ◽  
S. Hunklinger

2014 ◽  
Vol 134 (12) ◽  
pp. 1934-1935
Author(s):  
Tsunemasa Saiki ◽  
Yuya Matsui ◽  
Yasuto Arisue ◽  
Yuichi Utsumi ◽  
Akinobu Yamaguchi

2008 ◽  
Author(s):  
A. Kabulski ◽  
V. R. Pagán ◽  
D. Cortes ◽  
R. Burda ◽  
O. M. Mukdadi ◽  
...  

PIERS Online ◽  
2008 ◽  
Vol 4 (3) ◽  
pp. 346-350
Author(s):  
Mitsutaka Hikita ◽  
Keiya Minami ◽  
Koki Takimoto ◽  
Yasushi Hiraizumi

Sign in / Sign up

Export Citation Format

Share Document