scholarly journals Acute respiratory distress syndrome (ARDS) after pressurized intraperitoneal aerosol chemotherapy with oxaliplatin: a case report

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Emilie Thibaudeau ◽  
Corinne Brianchon ◽  
Jean-Luc Raoul ◽  
Frédéric Dumont
Keyword(s):  
Adverse Event ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Intraperitoneal Administration ◽  
Delivery Method ◽  
Minimally Invasive Approach ◽  
Invasive Approach ◽  
Serious Adverse Event

Abstract Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new drug delivery method for intraabdominal cavity chemotherapy. It combines the benefits of a minimally invasive approach (low morbidity and easy to repeat) with the pharmacokinetic advantages of intraperitoneal administration and tolerance seems excellent. We would like to report one case of a serious adverse event, acute respiratory distress syndrome, which is likely related to oxaliplatin administration; all signs disappeared within a few days.

The use of surfactant preparations in the absence of primary deficiency: publications, legal and regulatory framework

2021 ◽  
pp. 40-50
Author(s):  
S. V. Yargin
Keyword(s):  
Surface Tension ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Pulmonary Surfactant ◽  
Distress Syndrome ◽  
Experimental Models ◽  
Published Data ◽  
International Literature ◽  
Delivery Method

Pulmonary surfactant (Sf) reduces surface tension thus facilitating the widening of collapsed alveoli. Preparations of St are used in respiratory distress syndrome of the newborn — a condition with a primary deficiency of Sf. It was reported in some publications about successful use of Sf preparations in conditions without its primary deficiency: acute respiratory distress syndrome in children and adults, tuberculosis and others. Bronchoscopy was applied in some studies as a delivery method. It is argued here that some published data are theoretically unconvincing and not generally confirmed in the international literature. Further studies using different experimental models, adequately planned and performed to be reproducible, are necessary.

COVID-19 – eine vaskuläre Systemerkrankung

2020 ◽  
Vol 49 (10) ◽  
pp. 418-421
Author(s):  
Christopher Werlein ◽  
Peter Braubach ◽  
Vincent Schmidt ◽  
Nicolas J. Dickgreber ◽  
Bruno Märkl ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome

ZUSAMMENFASSUNGDie aktuelle COVID-19-Pandemie verzeichnet mittlerweile über 18 Millionen Erkrankte und 680 000 Todesfälle weltweit. Für die hohe Variabilität sowohl der Schweregrade des klinischen Verlaufs als auch der Organmanifestationen fanden sich zunächst keine pathophysiologisch zufriedenstellenden Erklärungen. Bei schweren Krankheitsverläufen steht in der Regel eine pulmonale Symptomatik im Vordergrund, meist unter dem Bild eines „acute respiratory distress syndrome“ (ARDS). Darüber hinaus zeigen sich jedoch in unterschiedlicher Häufigkeit Organmanifestationen in Haut, Herz, Nieren, Gehirn und anderen viszeralen Organen, die v. a. durch eine Perfusionsstörung durch direkte oder indirekte Gefäßwandschädigung zu erklären sind. Daher wird COVID-19 als vaskuläre Multisystemerkrankung aufgefasst. Vor dem Hintergrund der multiplen Organmanifestationen sind klinisch-pathologische Obduktionen eine wichtige Grundlage der Entschlüsselung der Pathomechanismen von COVID-19 und auch ein Instrument zur Generierung und Hinterfragung innovativer Therapieansätze.

The incresed risk of acute respiratory distress syndrome following caesarean section

2017 ◽  
Vol 1 (15) ◽  
pp. 44
Author(s):  
Mircea Octavian Poenaru ◽  
Anca Daniela Stănescu ◽  
Delia Carp ◽  
Romina-Marina Sima ◽  
Liana Pleș
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Caesarean Section ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome
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