Genetic Analysis of the Role of Protein Kinase C Signaling Pathways in Behaviors by Direct Gene Transfer with HSV-1 Vectors

1999 ◽  
Vol 10 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Alfred I. Geller
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Gene Transfer ◽  
Genetic Analysis ◽  
Signaling Pathways ◽  
Direct Gene Transfer ◽  
Kinase C ◽  
Direct Gene ◽  
Hsv 1

Abstract 2142: Signaling pathways involved in apoptosis-resistance against doxorubicin analogues in murine mammary cells; Role of protein kinase C delta (PKCΔ)

2011 ◽  
Author(s):  
María Inés Díaz Bessone ◽  
Damian E. Berardi ◽  
Paola B. Campodónico ◽  
Leonard Lothstein ◽  
Laura B. Todaro ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Signaling Pathways ◽  
Mammary Cells ◽  
Apoptosis Resistance ◽  
Protein Kinase C Delta ◽  
Kinase C

scholarly journals Potential Role of Protein Kinase C in the Pathophysiology of Diabetes-Associated Atherosclerosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Chih-Feng Lien ◽  
Sy-Jou Chen ◽  
Min-Chien Tsai ◽  
Chin-Sheng Lin
Keyword(s):  
Oxidative Stress ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Signaling Pathways ◽  
Vascular Complications ◽  
Cellular Responses ◽  
Diabetic Vascular Complications ◽  
Kinase C ◽  
Pkc Activation

Diabetes mellitus is a metabolic syndrome that affects millions of people worldwide. Recent studies have demonstrated that protein kinase C (PKC) activation plays an important role in hyperglycemia-induced atherosclerosis. PKC activation is involved in several cellular responses such as the expression of various growth factors, activation of signaling pathways, and enhancement of oxidative stress in hyperglycemia. However, the role of PKC activation in pro-atherogenic and anti-atherogenic mechanisms remains controversial, especially under hyperglycemic condition. In this review, we discuss the role of different PKC isoforms in lipid regulation, oxidative stress, inflammatory response, and apoptosis. These intracellular events are linked to the pathogenesis of atherosclerosis in diabetes. PKC deletion or treatment with PKC inhibitors has been studied in the regulation of atherosclerotic plaque formation and evolution. Furthermore, some preclinical and clinical studies have indicated that PKCβ and PKCδ are potential targets for the treatment of diabetic vascular complications. The current review summarizes these multiple signaling pathways and cellular responses regulated by PKC activation and the potential therapeutic targets of PKC in diabetic complications.

Role of protein kinase C in the regulation of steroidogenesis in the mouse Leydig cell

1986 ◽  
Vol 113 (1_Suppl) ◽  
pp. S63-S64
Author(s):  
A. K. MUKHOPADHYAY ◽  
H. G. BOHNET
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Leydig Cell ◽  
Kinase C ◽  
Mouse Leydig Cell

scholarly journals Dysregulation of protein kinase C in adult depression and suicide: evidence from postmortem brain studies

2021 ◽  
Author(s):  
Ghanshyam N Pandey ◽  
Anuradha Sharma ◽  
Hooriyah S Rizavi ◽  
Xinguo Ren
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Protein Expression ◽  
Mrna Expression ◽  
Postmortem Brain ◽  
Cortical Region ◽  
Cytosol Fraction ◽  
Kinase C ◽  
Pkc Isozymes

Abstract Background Several lines of evidence suggest the abnormalities of protein kinase C (PKC) signaling system in mood disorders and suicide based primarily on the studies of PKC and its isozymes in the platelets and postmortem brain of depressed and suicidal subjects. In this study we examined the role of PKC isozymes in depression and suicide. Methods We determined the protein and mRNA expression of various PKC isozymes in the prefrontal cortical region [Brodmann area 9 (BA9)] in 24 normal control (NC) subjects, 24 depressed suicide (DS) subjects and 12 depressed non-suicide (DNS) subjects. The levels of mRNA in the prefrontal cortex (PFC) were determined by qRT-PCR and the protein expression was determined by Western blotting. Results We observed a significant decrease in mRNA expression of PKCα, PKCβI, PKCδ and PKCε and decreased protein expression either in the membrane or the cytosol fraction of PKC isozymes - PKCα, PKCβI, PKCβII and PKCδ in DS and DNS subjects compared with NC subjects. Conclusions The current study provides detailed evidence of specific dysregulation of certain PKC isozymes in the postmortem brain of DS and DNS subjects and further supports earlier evidence for the role of PKC in the platelets and brain of adult and teenage depressed and suicidal population. This comprehensive study may lead to further knowledge of the involvement of PKC in the pathophysiology of depression and suicide.

scholarly journals Role of cadmium in activating nuclear protein kinase C and the enzyme binding to nuclear protein.

1992 ◽  
Vol 267 (28) ◽  
pp. 19824-19828
Author(s):  
C Block ◽  
S Freyermuth ◽  
D Beyersmann ◽  
A.N. Malviya
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Nuclear Protein ◽  
Enzyme Binding ◽  
Kinase C

Role of protein kinase C in the regulation of gap junctional communication

1994 ◽  
Vol 14 (6) ◽  
pp. 259-270 ◽  
Author(s):  
Irina V. Budunova ◽  
Leonid A. Mittelman ◽  
Joanna Miloszewska
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Gap Junctional Communication ◽  
Kinase C ◽  
Junctional Communication ◽  
Gap Junctional
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