scholarly journals Correlations Between Clinical Parameters and Health-Related Quality of Life in Postmenopausal Osteoporotic Women

2016 ◽  
Vol 17 (4) ◽  
pp. 333-342
Author(s):  
Vesna Grbovic ◽  
Aleksandra Jurisic Skevin ◽  
Katarina Parezanovic Ilic ◽  
Aleksandra Lucic Tomic ◽  
Jasmin Nurkovic ◽  
...  
Keyword(s):  
Femoral Neck ◽  
Biochemical Parameters ◽  
Health Perception ◽  
Mental Function ◽  
Health Related Quality ◽  
T Score ◽  
Related Quality ◽  
Health Related ◽  
Fracture History

Abstract The purpose of this study was to assess the correlation between health-related quality of life (HRQoL) and clinically relevant osteodensitometric and biochemical parameters in postmenopausal osteoporotic women. Bone mineral density (BMD) and T scores of the lumbar vertebrae and femoral neck were assessed in 100 osteoporotic women (56 without previous fractures and 44 with previous fractures) using dual x-ray absorptiometry. The Fracture Risk Assessment Tool (FRAX) index for major osteoporotic and hip fractures was calculated based on demographic data and hip BMD. Venous blood samples were taken from each subject for biochemical analysis (serum calcium, phosphorus, alkaline phosphatase and vitamin D levels). HRQoL was assessed using the QUALEFFO-41 questionnaire (domains: Health perception, Pain, and Physical, Social and Mental function). Basic participant characteristics (age, menopause length, body mass index, smoking habits, hereditary tendency towards fracture, fracture history) correlated with some of the QUALEFFO-41 domains, but the correlation coefficients were low (r<0.3), except in the case of the correlation between Pain and fracture history (r=0.638). Of the six variables included in the multiple regression model, fracture history was shown to be the most significant predictor with respect to the following three QUALEFFO-41 domains: Pain (b=20.511), Social function (b=2.548) and Health perception (b=3.185). Correlation analysis showed that after adjustment for basic characteristics, BMD and T score of the femoral neck and Pain (r=0.331 and r=0.449, respectively), Social function (r=0.422 and r=0.419) and Health perception (r=0.434 for T score of the femoral neck) exhibited the strongest correlations. Vitamin D was negatively correlated with Mental function, while the other biochemical parameters exhibited variable correlations with the QUALEFFO- 41 domains (r≈0.2-0.5). Our study confirmed the previously established relationship between BMD of the femoral neck and HRQoL in patients with osteoporosis and demonstrated correlations between various blood bone metabolism parameters and HRQoL that have not been previously investigated.

scholarly journals The paradox of aging and health-related quality of life in Asian Chinese: results from the Healthy Aging Longitudinal Study in Taiwan

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Han-Yun Tseng ◽  
Corinna Löckenhoff ◽  
Chun-Yi Lee ◽  
Shu-Han Yu ◽  
I-Chien Wu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Health ◽  
Healthy Aging ◽  
Mental Function ◽  
Health Related Quality ◽  
Objective Health ◽  
Related Quality ◽  
Health Related ◽  
Age Patterns

Abstract Background Declines in health, physical, cognitive, and mental function with age suggest a lower level of health-related quality of life (HRQoL) in late life; however, previous studies found that the associations were weak and varied, depending on the study designs and cohort characteristics. Methods The present study examined the paradox of aging in an East Asian context by regressing the age patterns of objective health indicators (physical, cognitive, and mental function), and subjective HRQoL (12-item Short Form, SF-12), on the independent and interactive effects of age and physical function in a cohort study of 5022 community-dwelling adults aged 55 and older in Taiwan. Results Age patterns differed across measures. The SF-12 mental health score (MCS) showed a slight positive association with age and this effect remained stable after controlling for various age-related covariates. The SF-12 physical health score (PCS), in turn, was negatively associated with age. Age differences in PCS were fully explained by age decrements in objective physical health. However, consistent with the so-called paradox of aging, the association between objective and subjective physical health weakened with age. Conclusion These findings add to prior evidence indicating that — in spite of objective health decrements — subjective HRQoL is maintained in later life among Asian Chinese. Also, these paradoxical patterns appear to vary for mental and physical components of HRQoL, and future research is needed to explore the underlying mechanism. Trial registration Healthy Aging Longitudinal Study in Taiwan (HALST) is retrospectively registered at ClinicalTrials.gov on January 24, 2016 with trial registration number NCT02677831.

Periodontal condition, changes in salivary biochemical parameters, and oral health‐related quality of life in patients with anorexia and bulimia nervosa

2019 ◽  
Vol 90 (12) ◽  
pp. 1423-1430
Author(s):  
Fernando Y. Chiba ◽  
Doris H. Sumida ◽  
Suzely A.S. Moimaz ◽  
Antônio H. Chaves Neto ◽  
Ana C.M.S. Nakamune ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Bulimia Nervosa ◽  
Biochemical Parameters ◽  
Health Related Quality ◽  
Periodontal Condition ◽  
Related Quality ◽  
Health Related

Physical Activity, Physical Fitness, and Health-Related Quality of Life in School-Aged Children

2016 ◽  
Vol 35 (2) ◽  
pp. 117-126 ◽  
Author(s):  
Xiangli Gu ◽  
Mei Chang ◽  
Melinda A. Solmon
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Physical Fitness ◽  
Mental Function ◽  
Health Related Quality ◽  
School Aged Children ◽  
Related Quality ◽  
Health Related ◽  
Fitness And Health

Purpose:This study examined the association between physical activity (PA), physical fitness, and health-related quality of life (HRQOL) among school-aged children.Methods:Participants were 201 children (91 boys, 110 girls; Mage = 9.82) enrolled in one school in the southern US. Students’ PA (self-reported PA, pedometer-based PA) and physical fitness (cardiorespiratory fitness, muscular fitness, flexibility, and body composition) were assessed in the fall. The PedsQL4.0 (Varni et al., 2001) was used to assess participants’ HRQOL (physical and mental function) in the spring.Results:PA and four components of physical fitness were positively associated with physical and mental function. Path analyses suggested physical fitness mediated the relationship between self-reported PA and HRQOL (95% CI: [.53, 1.48]), as well as between pedometer-based PA and HRQOL (95% CI: [.54, 1.53]).Discussion:Results support the conclusion that enhancing children’s physical fitness can facilitate positive outcomes including improved health related quality of life.

scholarly journals Factors associated with health-related quality of life, hip function, and health utility after operative management of femoral neck fractures

2018 ◽  
Vol 100-B (3) ◽  
pp. 361-369 ◽  
Author(s):  
S. Sprague ◽  
M. Bhandari ◽  
M. J. Heetveld ◽  
S. Liew ◽  
T. Scott ◽  
...  
Keyword(s):  
Femoral Neck ◽  
Health Utility ◽  
Health Related Quality ◽  
Factors Associated ◽  
Related Quality ◽  
Health Related ◽  
Neck Fracture ◽  
Hip Function ◽  
Baseline Factors

AimsThe primary aim of this prognostic study was to identify baseline factors associated with physical health-related quality of life (HRQL) in patients after a femoral neck fracture. The secondary aims were to identify baseline factors associated with mental HRQL, hip function, and health utility.Patients and MethodsPatients who were enrolled in the Fixation using Alternative Implants for the Treatment of Hip Fractures (FAITH) trial completed the 12-item Short Form Health Survey (SF-12), Western Ontario and McMaster Universities Arthritis Index, and EuroQol 5-Dimension at regular intervals for 24 months. We conducted multilevel mixed models to identify factors potentially associated with HRQL.ResultsThe following were associated with lower physical HRQL: older age (-1.42 for every ten-year increase, 95% confidence interval (CI) -2.17 to -0.67, p < 0.001); female gender (-1.52, 95% CI -3.00 to -0.05, p = 0.04); higher body mass index (-0.69 for every five-point increase, 95% CI -1.36 to -0.02, p = 0.04); American Society of Anesthesiologists class III ( versus class I) (-3.19, 95% CI -5.73 to -0.66, p = 0.01); and sustaining a displaced fracture (-2.18, 95% CI -3.88 to -0.49, p = 0.01). Additional factors were associated with mental HRQL, hip function, and health utility.ConclusionWe identified several baseline factors associated with lower HRQL, hip function, and utility after a femoral neck fracture. These findings may be used by clinicians to inform treatment and outcomes. Cite this article: Bone Joint J 2018;100-B:361–9.

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