scholarly journals Role of Calcium Channel Blockers in Myocardial Preconditioning

2017 ◽  
Vol 18 (4) ◽  
pp. 281-287 ◽  
Author(s):  
Nina Simonovic ◽  
Jovana Jeremic
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Calcium Channel ◽  
Reperfusion Injury ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Myocardial Preconditioning

AbstractCoronary heart disease is the leading cause of mortality and morbidity worldwide. The effects of coronary heart disease are usually attributable to the detrimental effects of acute myocardial ischaemia-reperfusion injury. Newer strategies such as ischaemic or pharmacological preconditioning have been shown to condition the myocardium to ischaemia-reperfusion injury and thus reduce the final infarct size. This review investigates the role of calcium channel blockers in myocardial preconditioning. Additionally, special attention is given to nicorandil whose mechanism of action may be associated with the cardioprotective effects of preconditioning. There are still many uncertainties in understanding the role of these agents in preconditioning, but future research in this direction will certainly help reduce coronary heart disease.

The influence of calcium channel blockers on Ca−P−Mg homeostasis and bone mass in patients with coronary heart disease and hypertension

1996 ◽  
Vol 6 (S1) ◽  
pp. 184-184 ◽  
Author(s):  
B. Kapitan-Malinowska ◽  
M. Tałalaj ◽  
E. Marcinowska-Suchowierska ◽  
J. Borowicz ◽  
H. Puchalska-Krotki
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Bone Mass ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers

Role of complement regulatory membrane proteins in ischaemia-reperfusion injury of rat gastric mucosa

1999 ◽  
Vol 14 (10) ◽  
pp. 967-972 ◽  
Author(s):  
Fumihiro Iwata ◽  
Takashi Joh ◽  
Toyohiro Tada ◽  
Noriko Okada ◽  
B Paul Morgan ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Membrane Proteins ◽  
Reperfusion Injury ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Rat Gastric Mucosa

Signaling mediators modulated by cardioprotective interventions in healthy and diabetic myocardium with ischaemia–reperfusion injury

2018 ◽  
Vol 25 (14) ◽  
pp. 1463-1481 ◽  
Author(s):  
Feyzizadeh Saeid ◽  
Javadi Aniseh ◽  
Badalzadeh Reza ◽  
Vafaee S Manouchehr
Keyword(s):  
Heart Disease ◽  
Reperfusion Injury ◽  
Ischaemic Heart Disease ◽  
Signaling Pathways ◽  
Intracellular Signaling ◽  
Heart Diseases ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Diabetic Myocardium ◽  
Patients With Diabetes

Ischaemic heart diseases are one of the major causes of death in the world. In most patients, ischaemic heart disease is coincident with other risk factors such as diabetes. Patients with diabetes are more prone to cardiac ischaemic dysfunctions including ischaemia–reperfusion injury. Ischaemic preconditioning, postconditioning and remote conditionings are reliable interventions to protect the myocardium against ischaemia–reperfusion injuries through activating various signaling pathways and intracellular mediators. Diabetes can disrupt the intracellular signaling cascades involved in these myocardial protections, and studies have revealed that cardioprotective effects of the conditioning interventions are diminished in the diabetic condition. The complex pathophysiology and poor prognosis of ischaemic heart disease among people with diabetes necessitate the investigation of the interaction of diabetes with ischaemia–reperfusion injury and cardioprotective mechanisms. Reducing the outcomes of ischaemia–reperfusion injury using targeted strategies would be particularly helpful in this population. In this study, we review the protective interventional signaling pathways and mediators which are activated by ischaemic conditioning strategies in healthy and diabetic myocardium with ischaemia–reperfusion injury.

The role of oxygen free radicals in the ischaemia - reperfusion injury

1987 ◽  
pp. 337-346
Author(s):  
F. Cuccurullo ◽  
A. Mezzetti ◽  
A. Arduini ◽  
E. Porreca ◽  
D. Lapenna ◽  
...  
Keyword(s):  
Free Radicals ◽  
Reperfusion Injury ◽  
Oxygen Free Radicals ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion
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