Field Desorption and Fast Atom Bombardment Mass Spectrometry of Spirostanol and Furostanol Saponins from Paris polyphylla

1984 ◽  
Vol 39 (3-4) ◽  
pp. 201-211 ◽  
Author(s):  
H.-R. Schulten ◽  
S. B. Singh ◽  
R. S. Thakur
Keyword(s):  
Mass Spectrometry ◽  
Molecular Weight ◽  
Natural Products ◽  
Fast Atom Bombardment ◽  
Structural Elucidation ◽  
Molecular Weight Determination ◽  
Field Desorption ◽  
Furostanol Saponins ◽  
Paris Polyphylla ◽  
Purity Control

The application of field desorption and fast atom bombardm ent mass spectrometry for molecular weight determination and structural elucidation of spirostanol and furostanol saponins isolated from Paris Polyphylla Sm. (Liliaceae) is reported. The capacity and limitations of these methods for sugar sequencing, differentiation of isomers and purity control of oligoglycosidic natural products are discussed

Field Desorption Mass Spectrometry of Physiologically Active Steroid-and Dammarane-Saponins

1979 ◽  
Vol 34 (12) ◽  
pp. 1094-1105 ◽  
Author(s):  
T. Komori ◽  
M. Kawamura ◽  
K. Miyahara ◽  
T. Kawasaki ◽  
O. Tanaka ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Natural Products ◽  
Complete Sequence ◽  
Solution Chemistry ◽  
Molecular Weight Determination ◽  
Field Desorption ◽  
Desorption Mass Spectrometry ◽  
Alkali Salt ◽  
Detailed Structural Analysis ◽  
Field Desorption Mass Spectrometry

The use of field desorption mass spectrometry is demonstrated not only for molecular weight determination but also for detailed structural analysis of large, underivatized natural products. Owing to cationization by small alkali salt impurities, saponins carrying one to four sugar units gave abundant quasimolecular ions. In addition, the observed sequence-specific fragment ions reflected the complete sequence of the sugar units in the oligoglycosides. This fragmentation of the oligosaccharidic moiety of the natural products was interpreted by analogy with acidic solvolysis, a mechanism well established in solution chemistry. Of particular interest was a first com­parison of the field desorption mass spectra obtained from two different commercially available instruments operated by different groups in order to give an estimate of interlaboratory reproducibility in field desorption mass spectrometry.

Applications of Mass Spectrometry to the Analysis of Mycotoxins

1976 ◽  
Vol 59 (5) ◽  
pp. 1016-1022
Author(s):  
David G I Kingston
Keyword(s):  
Mass Spectrometry ◽  
Molecular Weight ◽  
Special Reference ◽  
Structural Elucidation ◽  
Fungal Metabolites ◽  
Complete Listing

Abstract Methods of identifying mycotoxins by mass spectrometry are reviewed, with special reference to the value of a complete listing of known fungal metabolites, arranged by molecular weight. Such a list is applied to the identification of various mycotoxins, and mass spectrometry is applied to the structural elucidation of dimethylnidurufin and ostreogrycin A.

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