Asenapine review, part I: chemistry, receptor affinity profile, pharmacokinetics and metabolism

2014 ◽  
Vol 10 (6) ◽  
pp. 893-903 ◽  
Author(s):  
Leslie Citrome
Keyword(s):  
Receptor Affinity ◽  
Affinity Profile

ChemInform Abstract: Synthesis and Receptor-Affinity Profile of N-Hydroxytryptamine Derivatives for Serotonin and Tryptamine Receptors. A Molecular- Modeling Study.

ChemInform ◽  
2010 ◽  
Vol 24 (31) ◽  
pp. no-no
Author(s):  
G. D. H. DIJKSTRA ◽  
M. TH. M. TULP ◽  
P. H. H. HERMKENS ◽  
J. H. VAN MAARSEVEEN ◽  
H. W. SCHEEREN ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Receptor Affinity ◽  
Molecular Modeling Study ◽  
Affinity Profile ◽  
Modeling Study

Synthesis and receptor-affinity profile of N-hydroxytryptamine derivatives for serotonin and tryptamine receptors. A molecular-modeling study

2010 ◽  
Vol 112 (2) ◽  
pp. 131-136 ◽  
Author(s):  
Gerard D. H. Dijkstra ◽  
Martin Th. M. Tulp ◽  
Pedro H. H. Hermkens ◽  
Jan H. van Maarseveen ◽  
Hans W. Scheeren ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Receptor Affinity ◽  
Molecular Modeling Study ◽  
Affinity Profile ◽  
Modeling Study

Urinary incontinence and diarrhoea associated with the switch from oral to injectable risperidone

2013 ◽  
Vol 25 (2) ◽  
pp. 119-121 ◽  
Author(s):  
Enrica Di Rosa ◽  
Daniela Caldirola ◽  
Achille Motta ◽  
Giampaolo Perna
Keyword(s):  
Urinary Incontinence ◽  
Side Effects ◽  
Clinical Outcome ◽  
Poor Compliance ◽  
Urgency Urinary Incontinence ◽  
Type Method ◽  
Receptor Affinity ◽  
Dose Dependent ◽  
Affinity Profile

ObjectiveUrgency, urinary incontinence and bowel disturbances are distressing side effects that have been observed during treatment with risperidone and other antipsychotics probably due to the receptor affinity profile. This occurrence can lead to poor compliance and therefore impair clinical outcome.MethodWe report the case of a 50 year‐old lady, who experienced urinary incontinence and diarrhoea, when switching from oral to injectable risperidone, which ceased when discontinuing the drug.Results and conclusionsIt should be taken into account that some side effects can be revealed when switching from oral to depot formulations due to non‐compliance to orals; nevertheless dose‐dependent mechanisms and individual metabolic variability must be considered when observing idiosyncratic reactions to drugs.

scholarly journals Characterization of a membrane regulator of insulin receptor affinity.

1983 ◽  
Vol 258 (11) ◽  
pp. 6875-6881 ◽  
Author(s):  
J T Harmon ◽  
J A Hedo ◽  
C R Kahn
Keyword(s):  
Insulin Receptor ◽  
Receptor Affinity
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