scholarly journals Epidemiology and Estimating the Risk Factors for the Transfer of Hepatitis B Virus Using Multivariate Analysis Model: A Retrospective Case-Control Study

2019 ◽  
Vol 6 (2) ◽  
pp. 70-75
Author(s):  
Mansour Bahardoust ◽  
Marjan Mokhtare ◽  
Arash Sarveazad ◽  
Shahdieh Karimi ◽  
Atefeh Talebi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Case Control Study ◽  
Case Control ◽  
Hbv Infection ◽  
Retrospective Case ◽  
B Virus ◽  
History Of ◽  
Control Study

Background and aims: Hepatitis B virus (HBV) is one of the important public health diseases in Iran. Therefore, to control the prevalence of the disease, knowledge is required regarding the risk factor of HBV. Accordingly, the aim of this study was to determine the risk factors of HB transmission. Methods: A retrospective case-control study was conducted on the possible risk factors of HBV transmission. To this end, a total of 171 patients with HBV infection and 171 controls from Rasoul-eAkram hospital were investigated during 2015-2018. All subjects were directly evaluated using a faceto-face questionnaire about demographic aspects. Finally, HBV infection and its risk factors among the subjects were detected using hepatitis B surface antigen test. Results: Overall, 171 HBV patients including 77 (42%) males and 93 (58%) females were evaluated. The mean age of the participants was 40 ± 13 years. Univariate logistic analysis showed that HBV infection in these cases was associated with addiction injection (odds ratio [OR] = 4.08, CI:1.3- 9.57), family history (OR = 4.52, CI: 1.27-10.7), and having a history of blood transfusion (OR = 3.16, CI: 1.52-5.37). There were no significant relationships between the liver function tests, alcohol consumption, the history of dental visits, and HBV participants. In addition, the logistic-regression model proved that patients with a history of HBV-infected parents (At least one of them) and addiction injection were severely subject to HB infection. In other words, there was a significant association between a history of HBV-infected parents and addiction injection and HB infection. Conclusion: In general, HBV infection was strongly related to having a family member infected with hepatitis B, suffering from addiction injection, and having blood injection.

Risk factors and mechanism of transplacental transmission of hepatitis B virus: A case-control study

2002 ◽  
Vol 67 (1) ◽  
pp. 20-26 ◽  
Author(s):  
De-Zhong Xu ◽  
Yong-Ping Yan ◽  
Bernard C.K. Choi ◽  
Jian-Qiu Xu ◽  
Ke Men ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Case Control Study ◽  
Case Control ◽  
Transplacental Transmission ◽  
B Virus ◽  
Control Study

scholarly journals Hepatitis B virus infection and its determinants among HIV positive pregnant women: Multicenter unmatched case-control study

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0251084
Author(s):  
Zelalem Alamrew Anteneh ◽  
Estifanose Wondaye ◽  
Endalkachew Worku Mengesha
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Pregnant Women ◽  
Case Control Study ◽  
Hbv Infection ◽  
Hiv Positive ◽  
Unsafe Sex ◽  
B Virus ◽  
History Of ◽  
Control Study

Background Hepatitis B virus (HBV) kills millions of people globally; it is worse in pregnant women. HBV and Human Immune Virus (HIV) co-infection is associated with increased liver diseases such as cirrhosis and hepatocellular carcinoma. This study aimed at identifying the determinants of HBV infection among HIV-positive pregnant women. Methods A multicentre unmatched case-control study was conducted among 109 cases (HBV/HIV co-infected) and 327 controls (HIV positive) pregnant women in seven hospitals of the Eastern Amhara region. Interview and chart review data collection techniques were employed by trained personnel. A binary logistic regression model was used to identify independent predictors of hepatitis B virus infection. Variables with a p-value of <0.05 and 95% confidence interval for odds ratio not containing 1 considered independent predictors of HBV infection. Results The findings of this study revealed that history of STI [AOR, 1.97, 95%CI, 1.09–3.56], hospital admission [AOR, 3.08, 95%CI, 1.69–5.61], traditional delivery care [AOR, 3.31, 95%CI, 1.72–6.37], family history of HBV [AOR, 3.33, 95%CI, 1.72–6.37], presence of opportunistic infections [AOR, 0.23, 95%CI, 0.12–0.58], viral load [AOR, 7.58, 95%CI, 3.18–8.01], CD4 count [AOR, 2.15, 95% CI, 1.01–4.59], anaemia [AOR, 3.07, 95% CI, 1.71–5.51] and unsafe sex [AOR, 1.98, 95%CI, 1.09–3.61] had a statistically significant association with HBV infection. Conclusions Several exposure variables had statistically significant association with HBV infection. High Viral Load appeared to be the largest predictor of HBV infection in HIV patients. Therefore, targeted interventions such as behavioral change intervention for unsafe sex and STI should be in place, and screening tests and treatment at the early stage of conception for both partners is necessary.

scholarly journals Case-control study to evaluate risk factors for acute hepatitis B virus infection in Egypt

2010 ◽  
Vol 16 (01) ◽  
pp. 4-9 ◽  
Author(s):  
M. Talaat ◽  
E. Radwan ◽  
N. El Sayed ◽  
T. Ismael ◽  
R. Hajjeh ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Case Control Study ◽  
Case Control ◽  
Hepatitis B Virus Infection ◽  
B Virus ◽  
Acute Hepatitis B ◽  
Control Study

scholarly journals Association of MBOAT7-TMC4 rs641738 with the risk of hepatocellular carcinoma and persistent infection of hepatitis B virus: a case-control study and meta-analysis

2019 ◽  
Author(s):  
Peng Wang ◽  
Yu Zhou ◽  
Lu Li ◽  
Yajie Gong ◽  
Rong Zhong ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Hbv Infection ◽  
B Virus ◽  
Control Study

Abstract Background: Recent studies reported that a hot genetic variant, rs641738 within the membrane bound O-acyltransferase domain containing 7(MBOAT7) and transmembrane channel-like 4 (TMC4) , was associated with several liver diseases. However, results are still conflicting. We conducted this study to explore the role of MBOAT7-TMC4 rs641738 in the risk of hepatocellular carcinoma (HCC) and persistent hepatitis B virus (HBV) infection. Methods: We first performed a case-control study by including 779 HCC cases and 1412 cancer-free controls. Controls are consisted of 678 HBV persistent carriers and 734 spontaneously recovered subjects. Rs641738 was genotyped by MassARRAY platform. Results were analyzed by multivariate logistic regression analysis under five genetic models. Second, we conducted a systematic review and meta-analysis to further explore the role of this variant in HCC risk. Results: Results suggested no association between MBOAT7-TMC4 rs641738 and HCC risk in most genetic models (All P > 0.05), although a marginally significant association was observed in TT vs. CC ( P = 0.037) and recessive model ( P = 0.044). Further meta-analysis including 2135 HCC cases and 4388 controls supported that this variant was not related to HCC risk, even in the TT vs. CC and recessive models. Besides, we identified that this variant also had no influence on persistent HBV infection. Conclusion: Our work highlights that MBOAT7-TMC4 rs641738 is not associated with the risk of HCC or persistent HBV infection. This study provides some clues to identify the “truth” of potential disease-related genetic factors in the post-genome era.

scholarly journals Hepatitis B virus pre-S deletion mutations are a risk factor for hepatocellular carcinoma: a matched nested case–control study

2008 ◽  
Vol 89 (11) ◽  
pp. 2882-2890 ◽  
Author(s):  
Zhong-Liao Fang ◽  
Caroline A. Sabin ◽  
Bai-Qing Dong ◽  
Shao-Chao Wei ◽  
Qin-Yan Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Factor ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Case Control Study ◽  
Case Control ◽  
Deletion Mutations ◽  
B Virus ◽  
Nested Case Control ◽  
Control Study

A matched nested case–control study of 33 paired cases and controls was conducted, based on a study cohort in Long An county, Guangxi, China, to determine whether infection with hepatitis B virus (HBV) with pre-S deletions is independently associated with the development of hepatocellular carcinoma (HCC), without the confounding effects of basal core promoter (BCP) double mutations. The prevalence of pre-S deletions was significantly higher in HCC (45.5 %, 15 of 33) than the controls (18.2 %, 6 of 33) (P<0.01), under the control of the influence of BCP double mutations. Most of the pre-S deletions occurred in, or involved, the 5′ half of the pre-S2 region and the difference between HCC (93.3 %, 14 of 15) and controls (66.7 %, four of six) was significant for this region (P=0.015). There was no significant difference in pre-S deletions between the BCP mutant group and BCP wild-type group (P>0.05), nor was the prevalence of pre-S deletions significantly different between genotypes B and C (P>0.1). These results suggest that pre-S deletions constitute an independent risk factor for HCC and their emergence and effect are independent of BCP mutations. The 5′ terminus of pre-S2 is the favoured site for the deletion mutations, especially in HCC cases. Further prospective studies are required to confirm the role of these mutations in the development of HCC.

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