The X-ray Repair Cross-Complementing Group 1 Arg399Gln Genetic Polymorphism and Risk of Hepatocellular Carcinoma in an Iranian Population

Visualization of the microvascular network and thrombi in the microvasculature is a key step to evaluating the development of tumor growth and metastasis, and influences treatment selection. X-ray phase-contrast computed tomography (PCCT) is a new imaging technique that can detect minute changes of density and reveal soft tissues discrimination at micrometer-scale resolution. In this study, six human resected hepatocellular carcinoma (HCC) tissues were investigated with PCCT. A histological stain was added to estimate the accuracy of PCCT. The results showed that the fine structures of the microvasculature (measuring 30–100 µm) and thrombi in tiny blood vessels were displayed clearly on imaging the HCC tissues by PCCT. Moreover, density distributions of the thrombi were obtained, which could be reliably used to distinguish malignant from benign thrombi in HCC. In conclusion, PCCT can clearly show the three-dimensional subtle structures of HCC that cannot be detected by conventional absorption-based computed tomography and provides a new method for the imageology of HCC.

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The XRCC1 Arg399Gln Genetic Polymorphism Contributes to Hepatocellular Carcinoma Susceptibility: An Updated Meta-analysis

Asian Pacific Journal of Cancer Prevention ◽

10.7314/apjcp.2013.14.10.5761 ◽

2013 ◽

Vol 14 (10) ◽

pp. 5761-5767 ◽

Cited By ~ 4

Author(s):

Yan Pan ◽

Lei Zhao ◽

Xing-Miao Chen ◽

Yong Gu ◽

Jian-Gang Shen ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Genetic Polymorphism ◽

Meta Analysis ◽

Xrcc1 Arg399gln

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Low Dose X-Ray Sources and High Quantum Efficiency Sensors: The Next Challenge in Dental Digital Imaging?

Radiology Research and Practice ◽

10.1155/2014/543524 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7

Author(s):

Arnav R. Mistry ◽

Daniel Uzbelger Feldman ◽

Jie Yang ◽

Eric Ryterski

Keyword(s):

Low Dose ◽

Image Resolution ◽

X Ray ◽

Imaging Technologies ◽

Group 4 ◽

X Ray Imaging ◽

Group 3 ◽

Group 5 ◽

Group 2 ◽

Group 1

Objective(s). The major challenge encountered to decrease the milliamperes (mA) level in X-ray imaging systems is the quantum noise phenomena. This investigation evaluated dose exposure and image resolution of a low dose X-ray imaging (LDXI) prototype comprising a low mA X-ray source and a novel microlens-based sensor relative to current imaging technologies.Study Design. A LDXI in static (group 1) and dynamic (group 2) modes was compared to medical fluoroscopy (group 3), digital intraoral radiography (group 4), and CBCT scan (group 5) using a dental phantom.Results. The Mann-Whitney test showed no statistical significance(α=0.01)in dose exposure between groups 1 and 3 and 1 and 4 and timing exposure (seconds) between groups 1 and 5 and 2 and 3. Image resolution test showed group 1 > group 4 > group 2 > group 3 > group 5.Conclusions. The LDXI proved the concept for obtaining a high definition image resolution for static and dynamic radiography at lower or similar dose exposure and smaller pixel size, respectively, when compared to current imaging technologies. Lower mA at the X-ray source and high QE at the detector level principles with microlens could be applied to current imaging technologies to considerably reduce dose exposure without compromising image resolution in the near future.

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