This paper presents experimental and simulation results of the change in the chloride diffusion coefficient of concrete C40 (f’c=40 MPa) during axial loading. Test Method for Electrical Indication was used to measure the chloride diffusivity of the concrete sample during the axial loading. A mesoscopic lattice model is proposed to describe the variation of chloride diffusion coefficient versus damage variable. In such a model, the domain of material is discretized randomly by using Voronoi tessellation for the transport element and Delaunay triangulation for a mechanical element. At the mesoscale, the concrete is constituted by three phases: aggregate, cement paste and ITZ, in which aggregate is assumed to be elastic while cement matrix and ITZ are represented by a damage model with softening. The experimental and numerical results show that in the first stage, without crack (s < 40%smax), the chloride diffusion coefficient remains almost constant, however in the crack initiation and propagation stage (s = 60-80%smax) chloride diffusion coefficient increases significantly. An empirical power model is also proposed to describe the increase of the chloride diffusion coefficient versus stress level and damage variable.