Chapter 1 Scope of Phase I Environmental Site Assessments

Entering the Clinic

Adverse Events ◽

10.18574/nyu/9781479877997.003.0002 ◽

2020 ◽

pp. 21-48

Author(s):

Jill A. Fisher

Keyword(s):

Phase I ◽

Healthy Volunteers ◽

Sense Of Place ◽

Field Work ◽

Social World ◽

Demographic Information ◽

Research Staff

Chapter 1 provides ethnographic detail about entering and being confined to a Phase I clinic. It provides a sense of place: what one such clinic looks like and how it operates as well as the clinic’s social world, including the camaraderie and conflicts among healthy volunteers. The project methods are described, including how access to the six clinics was gained for the study, how field work was conducted, and the demographic information for the research staff and healthy volunteers who were included in the study.

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Chapter 1: Scope of Phase I Environmental Site Assessments

Technical Aspects of Phase I/II Environmental Site Assessments: 2nd Edition ◽

10.1520/mnl11243m ◽

2009 ◽

pp. 15-15-11

Author(s):

Zdenek Hejzlar ◽

John Worlund

Keyword(s):

Phase I

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A Phonomotor Approach to Apraxia of Speech Treatment

American Journal of Speech-Language Pathology ◽

10.1044/2020_ajslp-19-00116 ◽

2020 ◽

Vol 29 (4) ◽

pp. 2109-2130

Author(s):

Lauren Bislick

Keyword(s):

Phase I ◽

Treatment Effects ◽

Single Case ◽

Motor Planning ◽

The Other ◽

Multimodal Approach ◽

Apraxia Of Speech ◽

Duration Of Treatment ◽

Treatment Gains ◽

Future Work

Purpose This study continued Phase I investigation of a modified Phonomotor Treatment (PMT) Program on motor planning in two individuals with apraxia of speech (AOS) and aphasia and, with support from prior work, refined Phase I methodology for treatment intensity and duration, a measure of communicative participation, and the use of effect size benchmarks specific to AOS. Method A single-case experimental design with multiple baselines across behaviors and participants was used to examine acquisition, generalization, and maintenance of treatment effects 8–10 weeks posttreatment. Treatment was distributed 3 days a week, and duration of treatment was specific to each participant (criterion based). Experimental stimuli consisted of target sounds or clusters embedded nonwords and real words, specific to each participants' deficit. Results Findings show improved repetition accuracy for targets in trained nonwords, generalization to targets in untrained nonwords and real words, and maintenance of treatment effects at 10 weeks posttreatment for one participant and more variable outcomes for the other participant. Conclusions Results indicate that a modified version of PMT can promote generalization and maintenance of treatment gains for trained speech targets via a multimodal approach emphasizing repeated exposure and practice. While these results are promising, the frequent co-occurrence of AOS and aphasia warrants a treatment that addresses both motor planning and linguistic deficits. Thus, the application of traditional PMT with participant-specific modifications for AOS embedded into the treatment program may be a more effective approach. Future work will continue to examine and maximize improvements in motor planning, while also treating anomia in aphasia.

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Safety and early efficacy assessment of liposomal daunorubicin (DaunoXome) in adults with refractory or relapsed acute myeloblastic leukaemia: a phase I–II study

British Journal of Haematology ◽

10.1046/j.0007-1048.2001.03292.x ◽

2002 ◽

Vol 116 (2) ◽

pp. 308-315 ◽

Cited By ~ 1

Author(s):

A Fassas ◽

R Buffels ◽

A Anagnostopoulos ◽

E Gacos ◽

C Vadikolia ◽

...

Keyword(s):

Phase I ◽

Acute Myeloblastic Leukaemia ◽

Liposomal Daunorubicin ◽

Efficacy Assessment

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Quick Reference: Chapter 1: The Musculoskeletal System: The Hand and Upper Extremity

Guides Newsletter ◽

10.1001/amaguidesnewsletters.2000.sepoct03 ◽

2000 ◽

Vol 5 (5) ◽

pp. 4-5

Keyword(s):

Dorsal Column ◽

Persistent Pain ◽

Illness Behavior ◽

Abnormal Illness Behavior ◽

Organ Systems ◽

Spinal Cord Dorsal ◽

Objective Basis ◽

Dorsal Column Stimulation ◽

Underlying Pathology

Abstract Spinal cord (dorsal column) stimulation (SCS) and intraspinal opioids (ISO) are treatments for patients in whom abnormal illness behavior is absent but who have an objective basis for severe, persistent pain that has not been adequately relieved by other interventions. Usually, physicians prescribe these treatments in cancer pain or noncancer-related neuropathic pain settings. A survey of academic centers showed that 87% of responding centers use SCS and 84% use ISO. These treatments are performed frequently in nonacademic settings, so evaluators likely will encounter patients who were treated with SCS and ISO. Does SCS or ISO change the impairment associated with the underlying conditions for which these treatments are performed? Although the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides) does not specifically address this question, the answer follows directly from the principles on which the AMA Guides impairment rating methodology is based. Specifically, “the impairment percents shown in the chapters that consider the various organ systems make allowance for the pain that may accompany the impairing condition.” Thus, impairment is neither increased due to persistent pain nor is it decreased in the absence of pain. In summary, in the absence of complications, the evaluator should rate the underlying pathology or injury without making an adjustment in the impairment for SCS or ISO.

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Fifth Edition: the New Standard

Guides Newsletter ◽

10.1001/amaguidesnewsletters.2000.novdec01 ◽

2000 ◽

Vol 5 (6) ◽

pp. 1-7

Author(s):

Christopher R. Brigham ◽

James B. Talmage ◽

Leon H. Ensalada

Keyword(s):

Musculoskeletal System ◽

Medical Information ◽

Objective Assessment ◽

Scientific Data ◽

Practical Application ◽

Fourth Edition ◽

Appropriate Use ◽

Medical Evaluation ◽

Single Set

Abstract The AMA Guides to the Evaluation of Permanent Impairment (AMA Guides), Fifth Edition, is available and includes numerous changes that will affect both evaluators who and systems that use the AMA Guides. The Fifth Edition is nearly twice the size of its predecessor (613 pages vs 339 pages) and contains three additional chapters (the musculoskeletal system now is split into three chapters and the cardiovascular system into two). Table 1 shows how chapters in the Fifth Edition were reorganized from the Fourth Edition. In addition, each of the chapters is presented in a consistent format, as shown in Table 2. This article and subsequent issues of The Guides Newsletter will examine these changes, and the present discussion focuses on major revisions, particularly those in the first two chapters. (See Table 3 for a summary of the revisions to the musculoskeletal and pain chapters.) Chapter 1, Philosophy, Purpose, and Appropriate Use of the AMA Guides, emphasizes objective assessment necessitating a medical evaluation. Most impairment percentages in the Fifth Edition are unchanged from the Fourth because the majority of ratings currently are accepted, there is limited scientific data to support changes, and ratings should not be changed arbitrarily. Chapter 2, Practical Application of the AMA Guides, describes how to use the AMA Guides for consistent and reliable acquisition, analysis, communication, and utilization of medical information through a single set of standards.

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