scholarly journals Intelligence GWAS hits: Selection signal or population structure? A test of the null hypothesis

The Winnower ◽  
2015 ◽  
Author(s):  
Davide Piffer

<em>Abstract.</em> —A suite of stage- and age-classified models are constructed to determine whether an apparently unusual event is the result of external, environmental causes in a small population. These models are used as a baseline, or null hypothesis, that such an event may result from population structure and demographic stochasticity. An observed multiyear reproductive delay in a pod of killer whales <em>Orcinus orca </em> is used as an example of this process. All models, regardless of their complexity, give the same qualitative result: the observed reproductive delay could not be explained by pod composition and demographic stochasticity; external causes have to be sought to explain this phenomenon.


Genetics ◽  
1992 ◽  
Vol 131 (2) ◽  
pp. 297-306 ◽  
Author(s):  
M G Milgroom ◽  
S E Lipari ◽  
W A Powell

Abstract We analyzed DNA fingerprints in the chestnut blight fungus, Cryphonectria parasitica, for stability, inheritance, linkage and variability in a natural population. DNA fingerprints resulting from hybridization with a dispersed moderately repetitive DNA sequence of C. parasitica in plasmid pMS5.1 hybridized to 6-17 restriction fragments per individual isolate. In a laboratory cross and from progeny from a single perithecium collected from a field population, the presence/absence of 11 fragments in the laboratory cross and 12 fragments in the field progeny set segregated in 1:1 ratios. Two fragments in each progeny set cosegregated; no other linkage was detected among the segregating fragments. Mutations, identified by missing bands, were detected for only one fragment in which 4 of 43 progeny lacked a band present in both parents; no novel fragments were detected in any progeny. All other fragments appeared to be stably inherited. Hybridization patterns did not change during vegetative growth or sporulation. However, fingerprint patterns of single conidial isolates of strains EP155 and EP67 were found to be heterogenous due to mutations that occurred during culturing in the laboratory since these strains were first isolated in 1976-1977. In a population sample of 39 C. parasitica isolates, we found 33 different fingerprint patterns with pMS5.1. Most isolates differed from all other isolates by the presence or absence of several fragments. Six fingerprint patterns each occurred twice. Isolates with identical fingerprints occurred in cankers on the same chestnut stems three times; isolates within the other three pairs were isolated from cankers more than 5 m apart. The null hypothesis of random mating in this population could not be rejected if the six putative clones were removed from the analysis. Thus, a rough estimate of the clonal fraction of this population is 6 in 39 isolates (15.4%).


2001 ◽  
Vol 52 (7) ◽  
pp. 965 ◽  
Author(s):  
R. D. Ward ◽  
S. A. Appleyard ◽  
R. K. Daley ◽  
A. Reilly

Thirty eight allozyme loci were examined in orange and pink morphs of pink ling (Genypterus blacodes) and in rock ling (G. tigerinus). Six of the loci were species-diagnostic. No differences were observed between the orange and pink morphs, which appear to be the juvenile and adult forms respectively of pink ling. The pink ling forms an important component of Australia’s South-East Fishery and is managed as a single stock. Three polymorphic allozyme loci (average heterozygosity 0.324) and nine polymorphic microsatellite loci (average heterozygosity 0.823) were examined in collections of pink ling from five regions of the fishery. Estimates of the extent of population subdivision were effectively zero (F ST values per locus ranging from 0.0052 to –0.0065, P values non-significant), and the null hypothesis of a single pink ling stock in the South East Fishery could not be rejected.


2006 ◽  
Vol 11 (1) ◽  
pp. 12-24 ◽  
Author(s):  
Alexander von Eye

At the level of manifest categorical variables, a large number of coefficients and models for the examination of rater agreement has been proposed and used. The most popular of these is Cohen's κ. In this article, a new coefficient, κ s , is proposed as an alternative measure of rater agreement. Both κ and κ s allow researchers to determine whether agreement in groups of two or more raters is significantly beyond chance. Stouffer's z is used to test the null hypothesis that κ s = 0. The coefficient κ s allows one, in addition to evaluating rater agreement in a fashion parallel to κ, to (1) examine subsets of cells in agreement tables, (2) examine cells that indicate disagreement, (3) consider alternative chance models, (4) take covariates into account, and (5) compare independent samples. Results from a simulation study are reported, which suggest that (a) the four measures of rater agreement, Cohen's κ, Brennan and Prediger's κ n , raw agreement, and κ s are sensitive to the same data characteristics when evaluating rater agreement and (b) both the z-statistic for Cohen's κ and Stouffer's z for κ s are unimodally and symmetrically distributed, but slightly heavy-tailed. Examples use data from verbal processing and applicant selection.


1991 ◽  
Vol 46 (10) ◽  
pp. 1089-1089 ◽  
Author(s):  
John J. Bartko
Keyword(s):  

1998 ◽  
Vol 53 (7) ◽  
pp. 796-796 ◽  
Author(s):  
Warren W. Tyron
Keyword(s):  

1975 ◽  
Vol 20 (3) ◽  
pp. 212-213
Author(s):  
SEYMOUR FESHBACH
Keyword(s):  

1979 ◽  
Vol 24 (4) ◽  
pp. 299-301
Author(s):  
ALLAN E. PAULL ◽  
NEIL H. TIMM
Keyword(s):  

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