scholarly journals Sleep-State Dependent Alterations in Brain Functional Connectivity under Urethane Anesthesia in a Rat Model of Early-Stage Parkinson’s Disease

eNeuro ◽  
2019 ◽  
Vol 6 (1) ◽  
pp. ENEURO.0456-18.2019 ◽  
Author(s):  
Ekaterina Zhurakovskaya ◽  
Juuso Leikas ◽  
Tiina Pirttimäki ◽  
Francesc Casas Mon ◽  
Mikko Gynther ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Connectivity ◽  
Rat Model ◽  
Early Stage ◽  
Sleep State ◽  
Urethane Anesthesia ◽  
State Dependent ◽  
Brain Functional Connectivity

scholarly journals Functional connectivity of spoken language processing in early-stage Parkinson’s disease: an MEG study

2021 ◽  
pp. 102718
Author(s):  
Rasha Hyder ◽  
Mads Jensen ◽  
Andreas Højlund ◽  
Lilli Kimppa ◽  
Christopher J. Bailey ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Connectivity ◽  
Language Processing ◽  
Early Stage ◽  
Spoken Language ◽  
Spoken Language Processing

scholarly journals Marker-free imaging of α-Synuclein aggregates in a rat model of Parkinson’s disease using Raman microspectroscopy

2021 ◽  
Author(s):  
Fide Sevgi ◽  
Eva M Brauchle ◽  
Daniel A Carvajal Berrio ◽  
Katja Schenke-Layland ◽  
Nicolas Casadei ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Early Stage ◽  
Protein Structures ◽  
Lewy Bodies ◽  
Raman Microspectroscopy ◽  
Raman Imaging ◽  
Marker Free ◽  
The Brain

AbstractA hallmark of Parkinson’s disease (PD) is the formation of Lewy bodies in the brain. Lewy bodies are rich in the aggregated form of misfolded α-Synuclein (α-Syn). The brain from PD patients can only be analysed after post-mortem, limiting the diagnosis of PD to the manifestation of motor symptoms. In PD patients and animal models phosphorylated α-Syn was detected in the gut, thus, raising the hypothesizes that early-stage PD could be diagnosed based on colon tissues biopsies. Non-invasive marker-free technologies represent an ideal method to potentially detect aggregated α-Syn in vivo. Raman microspectroscopy has been established for the detection of molecular changes such as alterations of protein structures. Here, the olfactory bulb in the brain and the muscularis mucosae of colon tissue sections of a human BAC-SNCA transgenic (TG) rat model was analysed using Raman imaging and microspectroscopy. Raman images from TG and WT rats were investigated using spectral, principal component and true component analysis. Spectral components indicated protein aggregates (spheroidal oligomers) in TG rat brain and colon tissues even at a young age but not in WT. In summary, we have demonstrated that Raman imaging is capable to detect α-Syn aggregates in colon tissues of a PD rat model and making it a promising tool for future use in PD pathology.

Patterns of striatal and cerebellar functional connectivity in early-stage drug-naïve patients with Parkinson’s disease subtypes

2018 ◽  
Vol 60 (12) ◽  
pp. 1323-1333 ◽  
Author(s):  
Yanbing Hou ◽  
Ruwei Ou ◽  
Jing Yang ◽  
Wei Song ◽  
Qiyong Gong ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Connectivity ◽  
Early Stage ◽  
Drug Naïve ◽  
Disease Subtypes

Review of brain functional connectivity emotional analysis in Parkinson’s disease patients

2018 ◽  
Author(s):  
M. Mohammad Fauzi ◽  
A. H. Abdullah ◽  
Vikneswaran Vijean ◽  
M. Murugappan ◽  
M. A. A. Bakar
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Connectivity ◽  
Brain Functional Connectivity

scholarly journals Discriminative Analysis of Parkinson’s Disease Based on Whole-Brain Functional Connectivity

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0124153 ◽  
Author(s):  
Yongbin Chen ◽  
Wanqun Yang ◽  
Jinyi Long ◽  
Yuhu Zhang ◽  
Jieying Feng ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Connectivity ◽  
Whole Brain ◽  
Discriminative Analysis ◽  
Brain Functional Connectivity
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