scholarly journals Area-Specific Regulation of Quiescent Neural Stem Cells by Notch3 in the Adult Mouse Subependymal Zone

2017 ◽  
Vol 37 (49) ◽  
pp. 11867-11880 ◽  
Author(s):  
Hiroki Kawai ◽  
Daichi Kawaguchi ◽  
Benjamin D. Kuebrich ◽  
Takeo Kitamoto ◽  
Masahiro Yamaguchi ◽  
...  
2021 ◽  
Author(s):  
Zayna Chaker ◽  
Corina Segalada ◽  
Fiona Doetsch

Neural stem cells (NSCs) in the adult mouse brain contribute to lifelong brain plasticity. NSCs in the adult ventricular-subventricular zone (V-SVZ) are heterogeneous and, depending on their location in the niche, give rise to different subtypes of olfactory bulb interneurons. Here, we show that during pregnancy multiple regionally-distinct NSCs are dynamically recruited at different times. Coordinated temporal activation of these NSC pools generates sequential waves of short-lived olfactory bulb interneuron subtypes that mature in the mother around birth and in the perinatal care period. Concomitant with neuronal addition, oligodendrocyte progenitors also transiently increase in the olfactory bulb. Thus, life experiences, such as pregnancy, can trigger transient neurogenesis and gliogenesis under tight spatial and temporal control, and may provide a novel substrate for brain plasticity in anticipation of temporary physiological demand.


Stem Cells ◽  
2016 ◽  
Vol 34 (4) ◽  
pp. 888-901 ◽  
Author(s):  
Joo Yeon Kim ◽  
Kyuhyun Choi ◽  
Mohammed R. Shaker ◽  
Ju-Hyun Lee ◽  
Boram Lee ◽  
...  

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e113972 ◽  
Author(s):  
Rui Lan Zhang ◽  
Michael Chopp ◽  
Cynthia Roberts ◽  
Xianshuang Liu ◽  
Min Wei ◽  
...  

2010 ◽  
Vol 475 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Lori B. Bennett ◽  
Jingli Cai ◽  
Grigori Enikolopov ◽  
Lorraine Iacovitti

2014 ◽  
Vol 3 (6) ◽  
pp. 948-956 ◽  
Author(s):  
John P. Cassady ◽  
Ana C. D’Alessio ◽  
Sovan Sarkar ◽  
Vardhan S. Dani ◽  
Zi Peng Fan ◽  
...  

PPAR Research ◽  
2007 ◽  
Vol 2007 ◽  
pp. 1-10 ◽  
Author(s):  
A. Cimini ◽  
L. Cristiano ◽  
E. Benedetti ◽  
B. D'Angelo ◽  
M. P. Cerù

PPAR isotypes are involved in the regulation of cell proliferation, death, and differentiation, with different roles and mechanisms depending on the specific isotype and ligand and on the differentiated, undifferentiated, or transformed status of the cell. Differentiation stimuli are integrated by key transcription factors which regulate specific sets of specialized genes to allow proliferative cells to exit the cell cycle and acquire specialized functions. The main differentiation programs known to be controlled by PPARs both during development and in the adult are placental differentiation, adipogenesis, osteoblast differentiation, skin differentiation, and gut differentiation. PPARs may also be involved in the differentiation of macrophages, brain, and breast. However, their functions in this cell type and organs still awaits further elucidation. PPARs may be involved in cell proliferation and differentiation processes of neural stem cells (NSC). To this aim, in this work the expression of the three PPAR isotypes and RXRs in NSC has been investigated.


2019 ◽  
Vol 1723 ◽  
pp. 146425
Author(s):  
Erica L. McGrath ◽  
Caitlin R. Schlagal ◽  
Ibdanelo Cortez ◽  
Tiffany J. Dunn ◽  
Junling Gao ◽  
...  

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