Intraneuronal beta-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Neuron Loss ◽

Disease Mutations ◽

Amyloid Aggregates ◽

Familial Alzheimer's Disease ◽

Potential Factors

Age-Related Vascular Pathology in Transgenic Mice Expressing Presenilin 1-Associated Familial Alzheimer's Disease Mutations

American Journal Of Pathology ◽

10.2353/ajpath.2010.090482 ◽

2010 ◽

Vol 176 (1) ◽

pp. 353-368 ◽

Cited By ~ 49

Author(s):

Miguel A. Gama Sosa ◽

Rita De Gasperi ◽

Anne B. Rocher ◽

Athena Ching-Jung Wang ◽

William G.M. Janssen ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Transgenic Mice ◽

Vascular Pathology ◽

Presenilin 1 ◽

Age Related ◽

Disease Mutations ◽

O4-06-04: Intraneuronal Abeta42 aggregates seed amyloid plaques and cause neuronal loss in transgenic mice with five familial Alzheimer's disease mutations

Alzheimer s & Dementia ◽

10.1016/j.jalz.2006.05.339 ◽

2006 ◽

Vol 2 ◽

pp. S88-S88

Author(s):

Robert Vassar ◽

Holly Oakley ◽

Sreemathi Logan ◽

Erika Maus ◽

Pei Shao ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Transgenic Mice ◽

Neuronal Loss ◽

Amyloid Plaques ◽

Disease Mutations ◽

Familial Alzheimer’s disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of >45 residues

Journal of Biological Chemistry ◽

10.1016/j.jbc.2021.100281 ◽

2021 ◽

pp. 100281

Author(s):

Sujan Devkota ◽

Todd D. Williams ◽

Michael S. Wolfe

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Amyloid Β ◽

Amyloid Protein ◽

Protein Precursor ◽

Amyloid Protein Precursor ◽

Disease Mutations ◽

Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice

Journal of Neuroscience Research ◽

10.1002/jnr.22387 ◽

2010 ◽

Vol 88 (10) ◽

pp. 2103-2117 ◽

Cited By ~ 173

Author(s):

Michael Demars ◽

Yuan-Shih Hu ◽

Archana Gadadhar ◽

Orly Lazarov

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Transgenic Mice ◽

Early Event ◽

Familial Alzheimer's Disease ◽

Impaired Neurogenesis

Cerebellar Amyloid-β Plaques: Disturbed Cortical Circuitry in AβPP/PS1 Transgenic Mice as a Model of Familial Alzheimer's Disease

Journal of Alzheimer s Disease ◽

10.3233/jad-2012-112198 ◽

2012 ◽

Vol 31 (2) ◽

pp. 285-300 ◽

Cited By ~ 15

Author(s):

Selene Lomoio ◽

Irene López-González ◽

Ester Aso ◽

Margarita Carmona ◽

Benjamín Torrejón-Escribano ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Transgenic Mice ◽

Amyloid Β ◽

Cortical Circuitry ◽

β-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer’s disease mutations

Molecular Brain Research ◽

10.1016/s0169-328x(01)00294-7 ◽

2001 ◽

Vol 97 (1) ◽

pp. 103-113 ◽

Cited By ~ 44

Author(s):

Donna L McPhie ◽

Todd Golde ◽

Christopher B Eckman ◽

Debra Yager ◽

Justin B Brant ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Amyloid Precursor Protein ◽

Neuronal Apoptosis ◽

Precursor Protein ◽

Disease Mutations ◽

P2-378: Clinical and quantitative fluorodeoxyglucose positron emission tomography in presymptomatic and symptomatic persons inheriting familial Alzheimer's disease mutations

Alzheimer s & Dementia ◽

10.1016/j.jalz.2010.05.1430 ◽

2010 ◽

Vol 6 ◽

pp. S427-S427

Author(s):

John M. Ringman ◽

Soo K. Lee ◽

Jorge Barrio ◽

Giovanni Coppola ◽

Gary Small ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Positron Emission Tomography ◽

Emission Tomography ◽

Fluorodeoxyglucose Positron Emission Tomography ◽

Fluorodeoxyglucose Positron Emission

Positron Emission ◽

Disease Mutations ◽

Familial Alzheimer's Disease ◽

Enhanced Amyloidogenic Processing of the β-Amyloid Precursor Protein in Gene-targeted Mice Bearing the Swedish Familial Alzheimer's Disease Mutations and a “Humanized” Aβ Sequence

Journal of Biological Chemistry ◽

10.1074/jbc.271.38.23380 ◽

1996 ◽

Vol 271 (38) ◽

pp. 23380-23388 ◽

Cited By ~ 100

Author(s):

Andrew G. Reaume ◽

David S. Howland ◽

Stephen P. Trusko ◽

Mary J. Savage ◽

Diane M. Lang ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Amyloid Precursor Protein ◽

Precursor Protein ◽

Amyloidogenic Processing ◽

Disease Mutations ◽

Β Amyloid ◽

Aging‐related increase in oxidative stress correlates with developmental pattern of beta‐secretase activity and beta‐amyloid plaque formation in transgenic Tg2576 mice with Alzheimer‐like pathology

International Journal of Developmental Neuroscience ◽

10.1016/j.ijdevneu.2004.07.006 ◽

2004 ◽

Vol 22 (7) ◽

pp. 475-484 ◽

Cited By ~ 113

Author(s):

Jenny Apelt ◽

Marina Bigl ◽

Patrick Wunderlich ◽

Reinhard Schliebs

Keyword(s):

Oxidative Stress ◽

Amyloid Plaque ◽

Beta Amyloid ◽

Plaque Formation ◽

Developmental Pattern ◽

Secretase Activity ◽

Beta Secretase ◽

Tg2576 Mice ◽

Related Increase

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation

Nature Medicine ◽

10.1038/8438 ◽

1999 ◽

Vol 5 (5) ◽

pp. 560-564 ◽

Cited By ~ 247

Author(s):

De-Hua Chui ◽

Hiroshi Tanahashi ◽

Kazuharu Ozawa ◽

Sachiya Ikeda ◽

Frédéric Checler ◽

...

Keyword(s):

Transgenic Mice ◽

Amyloid Plaque ◽

Plaque Formation ◽

Presenilin 1