scholarly journals Blocking the Interaction between EphB2 and ADDLs by a Small Peptide Rescues Impaired Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer's Disease

2016 ◽  
Vol 36 (47) ◽  
pp. 11959-11973 ◽  
Author(s):  
Xiao-Dong Shi ◽  
Kai Sun ◽  
Rui Hu ◽  
Xiao-Ya Liu ◽  
Qiu-Mei Hu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Synaptic Plasticity ◽  
Mouse Model ◽  
Memory Deficits ◽  
Small Peptide ◽  
Model Of Alzheimer’S Disease

scholarly journals miR‐181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer’s disease

Aging Cell ◽  
2020 ◽  
Vol 19 (3) ◽  
Author(s):  
Carlos J. Rodriguez‐Ortiz ◽  
Gilberto Aleph Prieto ◽  
Alessandra C. Martini ◽  
Stefania Forner ◽  
Laura Trujillo‐Estrada ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Synaptic Plasticity ◽  
Mouse Model ◽  
Memory Deficits ◽  
Model Of Alzheimer’S Disease ◽  
Hippocampal Cultures

The flavonoid baicalein rescues synaptic plasticity and memory deficits in a mouse model of Alzheimer’s disease

2016 ◽  
Vol 311 ◽  
pp. 309-321 ◽  
Author(s):  
Xun-Hu Gu ◽  
Li-Jun Xu ◽  
Zhi-Qiang Liu ◽  
Bo Wei ◽  
Yuan-Jian Yang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Synaptic Plasticity ◽  
Mouse Model ◽  
Memory Deficits ◽  
Model Of Alzheimer’S Disease

scholarly journals Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

PLoS ONE ◽  
2010 ◽  
Vol 5 (9) ◽  
pp. e12845 ◽  
Author(s):  
Tao Ma ◽  
Charles A. Hoeffer ◽  
Estibaliz Capetillo-Zarate ◽  
Fangmin Yu ◽  
Helen Wong ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Synaptic Plasticity ◽  
Mouse Model ◽  
Mtor Pathway ◽  
Model Of Alzheimer’S Disease

scholarly journals Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Ke Hou ◽  
Jing Zhao ◽  
Hui Wang ◽  
Bin Li ◽  
Kexin Li ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gold Nanoparticles ◽  
Mouse Model ◽  
Chiral Recognition ◽  
Memory Deficits ◽  
Aβ Peptides ◽  
Promising Strategy ◽  
Model Of Alzheimer’S Disease ◽  
Behavioral Impairments

Abstract Preventing aggregation of amyloid beta (Aβ) peptides is a promising strategy for the treatment of Alzheimer’s disease (AD), and gold nanoparticles have previously been explored as a potential anti-Aβ therapeutics. Here we design and prepare 3.3 nm L- and D-glutathione stabilized gold nanoparticles (denoted as L3.3 and D3.3, respectively). Both chiral nanoparticles are able to inhibit aggregation of Aβ42 and cross the blood-brain barrier (BBB) following intravenous administration without noticeable toxicity. D3.3 possesses a larger binding affinity to Aβ42 and higher brain biodistribution compared with its enantiomer L3.3, giving rise to stronger inhibition of Aβ42 fibrillation and better rescue of behavioral impairments in AD model mice. This conjugation of a small nanoparticle with chiral recognition moiety provides a potential therapeutic approach for AD.

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