Human Apolipoprotein E4 Alters the Amyloid-  40:42 Ratio and Promotes the Formation of Cerebral Amyloid Angiopathy in an Amyloid Precursor Protein Transgenic Model

Precursor Protein ◽

Amyloid Angiopathy ◽

Apolipoprotein E4 ◽

Transgenic Model ◽

Human Apolipoprotein ◽

Apolipoprotein E Markedly Facilitates Age-Dependent Cerebral Amyloid Angiopathy and Spontaneous Hemorrhage in Amyloid Precursor Protein Transgenic Mice

Journal of Neuroscience ◽

10.1523/jneurosci.23-21-07889.2003 ◽

2003 ◽

Vol 23 (21) ◽

pp. 7889-7896 ◽

Cited By ~ 87

Author(s):

John D. Fryer ◽

Jennie W. Taylor ◽

Ronald B. DeMattos ◽

Kelly R. Bales ◽

Steven M. Paul ◽

...

Keyword(s):

Transgenic Mice ◽

Apolipoprotein E ◽

Precursor Protein ◽

Amyloid Angiopathy ◽

Spontaneous Hemorrhage ◽

Age Dependent ◽

Antisense Oligonucleotide-Induced Amyloid Precursor Protein Splicing Modulation as a Therapeutic Approach for Dutch-Type Cerebral Amyloid Angiopathy

Nucleic Acid Therapeutics ◽

10.1089/nat.2021.0005 ◽

2021 ◽

Author(s):

Elena Daoutsali ◽

Tsinatkeab T. Hailu ◽

Ronald A.M. Buijsen ◽

Barry A. Pepers ◽

Linda M. van der Graaf ◽

...

Keyword(s):

Antisense Oligonucleotide ◽

Therapeutic Approach ◽

Precursor Protein ◽

Amyloid Angiopathy ◽

Protein Splicing ◽

Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy

Annals of Neurology ◽

10.1002/ana.1009 ◽

2001 ◽

Vol 49 (6) ◽

pp. 697-705 ◽

Cited By ~ 323

Author(s):

Thomas J. Grabowski ◽

Hyun Soon Cho ◽

Jean Paul G. Vonsattel ◽

G. William Rebeck ◽

Steven M. Greenberg

Keyword(s):

Severe Cerebral Amyloid Angiopathy

Precursor Protein ◽

Amyloid Angiopathy ◽

Protein Mutation ◽

Amyloid Precursor Protein Mutation ◽

Cerebral Amyloid ◽

Exacerbation of Cerebral Amyloid Angiopathy-Associated Microhemorrhage in Amyloid Precursor Protein Transgenic Mice by Immunotherapy Is Dependent on Antibody Recognition of Deposited Forms of Amyloid

Journal of Neuroscience ◽

10.1523/jneurosci.4337-04.2005 ◽

2005 ◽

Vol 25 (3) ◽

pp. 629-636 ◽

Cited By ~ 206

Author(s):

M. M. Racke

Keyword(s):

Transgenic Mice ◽

Precursor Protein ◽

Amyloid Angiopathy ◽

Antibody Recognition ◽

β-Amyloid precursor protein gene in squirrel monkeys with cerebral amyloid angiopathy

Neurobiology of Aging ◽

10.1016/0197-4580(95)00090-2 ◽

1995 ◽

Vol 16 (5) ◽

pp. 805-808 ◽

Cited By ~ 14

Author(s):

Efrat Levy ◽

Angela Amorim ◽

Blas Frangione ◽

Lary C. Walker

Keyword(s):

Protein Gene ◽

Squirrel Monkeys ◽

Precursor Protein ◽

Amyloid Precursor Protein Gene ◽

Amyloid Angiopathy ◽

Β Amyloid ◽

Amyloid-β Contributes to Blood–Brain Barrier Leakage in Transgenic Human Amyloid Precursor Protein Mice and in Humans With Cerebral Amyloid Angiopathy

Stroke ◽

10.1161/strokeaha.111.627562 ◽

2012 ◽

Vol 43 (2) ◽

pp. 514-523 ◽

Cited By ~ 111

Author(s):

Anika M.S. Hartz ◽

Björn Bauer ◽

Emma L.B. Soldner ◽

Andrea Wolf ◽

Sandra Boy ◽

...

Keyword(s):

Blood Brain Barrier ◽

Amyloid Β ◽

Precursor Protein ◽

Brain Barrier ◽

Amyloid Angiopathy ◽

Blood Brain ◽

Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models

Acta Neuropathologica Communications ◽

10.1186/s40478-015-0250-y ◽

2015 ◽

Vol 3 (1) ◽

Cited By ~ 22

Author(s):

Fan Liao ◽

Tony J. Zhang ◽

Hong Jiang ◽

Katheryn B. Lefton ◽

Grace O. Robinson ◽

...

Keyword(s):

Transgenic Mouse ◽

Mouse Models ◽

Amyloid Plaques ◽

Amyloid Angiopathy ◽

Transgenic Mouse Models ◽

Apolipoprotein E4 ◽

Human Apolipoprotein ◽

Amyloid precursor protein-fragments-containing inclusions in cardiomyocytes with basophilic degeneration and its association with cerebral amyloid angiopathy and myocardial fibrosis

Scientific Reports ◽

10.1038/s41598-018-34808-7 ◽

2018 ◽

Vol 8 (1) ◽

Cited By ~ 4

Author(s):

Lara Maria Krämer ◽

Johannes Brettschneider ◽

Jochen K. Lennerz ◽

Daniel Walcher ◽

Lubin Fang ◽

...

Keyword(s):

Myocardial Fibrosis ◽

Precursor Protein ◽

Amyloid Angiopathy ◽

Protein Fragments ◽

Senile plaques in cerebral amyloid angiopathy show accumulation of amyloid precursor protein without cytoskeletal abnormalities

Brain Research ◽

10.1016/0006-8993(92)91323-7 ◽

1992 ◽

Vol 593 (2) ◽

pp. 299-303 ◽

Cited By ~ 8

Author(s):

M. Tabaton ◽

S. Cammarata ◽

T. Mandybur ◽

P. Richey ◽

M. Kawai ◽

...

Keyword(s):

Senile Plaques ◽

Precursor Protein ◽

Amyloid Angiopathy ◽

S3-03-04: Effects of human apolipoprotein E on familial cerebral amyloid angiopathy mutant Aβ deposition in a transgenic mouse model

Alzheimer s & Dementia ◽

10.1016/j.jalz.2008.05.388 ◽

2008 ◽

Vol 4 ◽

pp. T153-T154

Author(s):

William E. Van Nostrand

Keyword(s):

Mouse Model ◽

Apolipoprotein E ◽

Transgenic Mouse ◽

Transgenic Mouse Model ◽

Amyloid Angiopathy ◽

Human Apolipoprotein ◽