scholarly journals Reconsolidation or Extinction: Transcription Factor Switch in the Determination of Memory Course after Retrieval

2011 ◽  
Vol 31 (15) ◽  
pp. 5562-5573 ◽  
Author(s):  
V. de la Fuente ◽  
R. Freudenthal ◽  
A. Romano
Keyword(s):  
Transcription Factor

Retinoic acid establishes ventral retinal characteristics

Development ◽  
1996 ◽  
Vol 122 (1) ◽  
pp. 195-204 ◽  
Author(s):  
G.A. Hyatt ◽  
E.A. Schmitt ◽  
N. Marsh-Armstrong ◽  
P. McCaffery ◽  
U.C. Drager ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Retinoic Acid ◽  
Optic Nerve ◽  
Normal Development ◽  
Cell Content ◽  
Optic Stalk ◽  
Eye Field ◽  
Dorsal Retina ◽  
Choroid Fissure

The developing eye is known to be rich in retinoic acid (RA), and perturbations in RA levels during formation of the optic primordia, as well as RA receptor mutations, cause retinal malformations, especially in ventral eye regions. To test the hypothesis that RA plays a role in the establishment of ventral retinal characteristics, we examined several dorsal and ventral ocular markers in RA-treated zebrafish. The optic stalk represents the ventral-most region of the early eye field. During normal development, the optic stalks constrict, decreasing in width and are gradually replaced by the optic nerve. Systemic high RA levels cause an expansion in the optic stalk with an increased cell content and a patent lumen. In addition, the stalks do not constrict and persist into later stages of development indicating an enhancement of early ventral eye characteristics. Expression of the transcription factor pax[b], normally confined to the ventral retina, expands into the dorsal retina following RA treatment, whereas msh[c], normally expressed in the dorsal retinal pole, disappears. Activity of an aldehyde dehydrogenase that normally occupies the dorsal third of the retina is reduced or abolished following high systemic RA. When a localized RA source, an RA-soaked bead, is placed next to the developing eye, a fissure resembling the choroid fissure appears in the eye facing the bead. Taken together, these observations suggest that RA is involved in the determination of the ventral retina.

scholarly journals RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Barbara Nicol ◽  
Sara A. Grimm ◽  
Frédéric Chalmel ◽  
Estelle Lecluze ◽  
Maëlle Pannetier ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Granulosa Cell ◽  
Sertoli Cells ◽  
Transcriptional Control ◽  
Cell Lineage ◽  
Supporting Cell ◽  
Supporting Cells ◽  
Fate Specification ◽  
Fetal Ovary

Abstract Sex determination of the gonads begins with fate specification of gonadal supporting cells into either ovarian pre-granulosa cells or testicular Sertoli cells. This fate specification hinges on a balance of transcriptional control. Here we report that expression of the transcription factor RUNX1 is enriched in the fetal ovary in rainbow trout, turtle, mouse, goat, and human. In the mouse, RUNX1 marks the supporting cell lineage and becomes pre-granulosa cell-specific as the gonads differentiate. RUNX1 plays complementary/redundant roles with FOXL2 to maintain fetal granulosa cell identity and combined loss of RUNX1 and FOXL2 results in masculinization of fetal ovaries. At the chromatin level, RUNX1 occupancy overlaps partially with FOXL2 occupancy in the fetal ovary, suggesting that RUNX1 and FOXL2 target common sets of genes. These findings identify RUNX1, with an ovary-biased expression pattern conserved across species, as a regulator in securing the identity of ovarian-supporting cells and the ovary.

Determination of transcription factor binding

2010 ◽  
Vol 43 (1) ◽  
pp. 11-12 ◽  
Author(s):  
Edwin Cheung ◽  
Yijun Ruan
Keyword(s):  
Transcription Factor ◽  
Transcription Factor Binding ◽  
Factor Binding

Codon Optimization, Cloning, Expression, Purification, and Secondary Structure Determination of Human ETS2 Transcription Factor

2020 ◽  
Vol 62 (10) ◽  
pp. 485-494
Author(s):  
Krishna Kumar Haridhasapavalan ◽  
Pradeep Kumar Sundaravadivelu ◽  
Rajkumar P. Thummer
Keyword(s):  
Transcription Factor ◽  
Secondary Structure ◽  
Structure Determination ◽  
Codon Optimization

Determination of binding constant of transcription factor AP-1 and DNA

2001 ◽  
Vol 268 (3) ◽  
pp. 565-572 ◽  
Author(s):  
Haeyoung Kwon ◽  
Seyeon Park ◽  
Sangkyou Lee ◽  
Dug-Keun Lee ◽  
Chul-Hak Yang
Keyword(s):  
Transcription Factor ◽  
Binding Constant
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