scholarly journals Myeloid cells protect intestinal epithelial barrier integrity through the angiogenin/plexin‐B2 axis

2020 ◽  
Vol 39 (13) ◽  
Author(s):  
Rongpan Bai ◽  
Desen Sun ◽  
Muxiong Chen ◽  
Xiaoliang Shi ◽  
Liang Luo ◽  
...  
Keyword(s):  
Myeloid Cells ◽  
Epithelial Barrier ◽  
Intestinal Epithelial ◽  
Intestinal Epithelial Barrier ◽  
Barrier Integrity

scholarly journals A Novel Role of SLC26A3 in the Maintenance of Intestinal Epithelial Barrier Integrity

2020 ◽  
Author(s):  
Anoop Kumar ◽  
Shubha Priyamvada ◽  
Yong Ge ◽  
Dulari Jayawardena ◽  
Megha Singhal ◽  
...  
Keyword(s):  
Epithelial Barrier ◽  
Intestinal Epithelial ◽  
Intestinal Epithelial Barrier ◽  
Barrier Integrity

Effects of the cathelicidin LL-37 on intestinal epithelial barrier integrity

2009 ◽  
Vol 156 (1-3) ◽  
pp. 104-117 ◽  
Author(s):  
Jan-Michel Otte ◽  
Anna-Elisabeth Zdebik ◽  
Stephan Brand ◽  
Ansgar M. Chromik ◽  
Sarah Strauss ◽  
...  
Keyword(s):  
Epithelial Barrier ◽  
Intestinal Epithelial ◽  
Intestinal Epithelial Barrier ◽  
Barrier Integrity

Luminal bile acids region‐specifically strengthen intestinal epithelial barrier integrity after RYGB through FXR signaling

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Mohammed Hankir ◽  
Theresa Langseder ◽  
Yalda Ghoreishi ◽  
Malina Koenigsrainer ◽  
Ulrich Dischinger ◽  
...  
Keyword(s):  
Bile Acids ◽  
Epithelial Barrier ◽  
Intestinal Epithelial ◽  
Intestinal Epithelial Barrier ◽  
Barrier Integrity

scholarly journals Bovine dairy complex lipids improve in vitro measures of small intestinal epithelial barrier integrity

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0190839 ◽  
Author(s):  
Rachel C. Anderson ◽  
Alastair K. H. MacGibbon ◽  
Neill Haggarty ◽  
Kelly M. Armstrong ◽  
Nicole C. Roy
Keyword(s):  
Epithelial Barrier ◽  
Intestinal Epithelial ◽  
Intestinal Epithelial Barrier ◽  
Barrier Integrity ◽  
Complex Lipids ◽  
Small Intestinal

Lipid rafts are disrupted in mildly inflamed intestinal microenvironments without overt disruption of the epithelial barrier

2012 ◽  
Vol 302 (8) ◽  
pp. G781-G793 ◽  
Author(s):  
Rachel V. Bowie ◽  
Simona Donatello ◽  
Clíona Lyes ◽  
Mark B. Owens ◽  
Irina S. Babina ◽  
...  
Keyword(s):  
Lipid Rafts ◽  
Intestinal Permeability ◽  
Barrier Function ◽  
Epithelial Barrier ◽  
Intestinal Epithelial ◽  
Intestinal Epithelial Barrier ◽  
Epithelial Barrier Function ◽  
Barrier Integrity ◽  
Ifn Γ

Intestinal epithelial barrier disruption is a feature of inflammatory bowel disease (IBD), but whether barrier disruption precedes or merely accompanies inflammation remains controversial. Tight junction (TJ) adhesion complexes control epithelial barrier integrity. Since some TJ proteins reside in cholesterol-enriched regions of the cell membrane termed lipid rafts, we sought to elucidate the relationship between rafts and intestinal epithelial barrier function. Lipid rafts were isolated from Caco-2 intestinal epithelial cells primed with the proinflammatory cytokine interferon-γ (IFN-γ) or treated with methyl-β-cyclodextrin as a positive control for raft disruption. Rafts were also isolated from the ilea of mice in which colitis had been induced in conjunction with in vivo intestinal permeability measurements, and lastly from intestinal biopsies of ulcerative colitis (UC) patients with predominantly mild or quiescent disease. Raft distribution was analyzed by measuring activity of the raft-associated enzyme alkaline phosphatase and by performing Western blot analysis for flotillin-1. Epithelial barrier integrity was estimated by measuring transepithelial resistance in cytokine-treated cells or in vivo permeability to fluorescent dextran in colitic mice. Raft and nonraft fractions were analyzed by Western blotting for the TJ proteins occludin and zonula occludens-1 (ZO-1). Our results revealed that lipid rafts were disrupted in IFN-γ-treated cells, in the ilea of mice with subclinical colitis, and in UC patients with quiescent inflammation. This was not associated with a clear pattern of occludin or ZO-1 relocalization from raft to nonraft fractions. Significantly, a time-course study in colitic mice revealed that disruption of lipid rafts preceded the onset of increased intestinal permeability. Our data suggest for the first time that lipid raft disruption occurs early in the inflammatory cascade in murine and human colitis and, we speculate, may contribute to subsequent disruption of epithelial barrier function.

scholarly journals Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

2013 ◽  
Vol 5 (7) ◽  
pp. 1000-1016 ◽  
Author(s):  
Roosmarijn E. Vandenbroucke ◽  
Eline Dejonckheere ◽  
Filip Van Hauwermeiren ◽  
Sofie Lodens ◽  
Riet De Rycke ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Inflammatory Diseases ◽  
Epithelial Barrier ◽  
Intestinal Epithelial ◽  
Intestinal Epithelial Barrier ◽  
Barrier Integrity ◽  
Matrix Metalloproteinase 13
Sign in / Sign up

Export Citation Format

Share Document