scholarly journals Human Hair Follicle Cells with the Cell Surface Marker CD34 Can Regenerate New Mouse Hair Follicles and Located in the Outer Root Sheath of Immunodeficient Nude Mice

2008 ◽  
Vol 1 (1) ◽  
pp. 70-81 ◽  
Author(s):  
Sung-Hoon Lee ◽  
Mi-Kyung Chung ◽  
Yong-Jin Sohn ◽  
Yong-Soon Lee ◽  
Kyung-Sun Kang
Keyword(s):  
Cell Surface ◽  
Hair Follicle ◽  
Nude Mice ◽  
Human Hair ◽  
Hair Follicles ◽  
Surface Marker ◽  
Follicle Cells ◽  
Human Hair Follicle ◽  
Outer Root Sheath ◽  
Root Sheath

scholarly journals Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells

2021 ◽  
Vol 43 (3) ◽  
pp. 1361-1373
Author(s):  
Jae Young Shin ◽  
Jaeyoon Kim ◽  
Yun-Ho Choi ◽  
Nae-Gyu Kang ◽  
Sanghwa Lee
Keyword(s):  
Cell Viability ◽  
Hair Follicle ◽  
Human Hair ◽  
Cellular Proliferation ◽  
Hair Follicles ◽  
Cell Senescence ◽  
Follicle Cells ◽  
Human Hair Follicle ◽  
Outer Root Sheath ◽  
Anagen Phase

Dexpanthenol (D-panthenol) is a precursor of vitamin B5 (pantothenic acid) and is widely used for dietary supplements and topical applications. D-panthenol has long been used in hair care products for the purpose of anti-hair loss, its effects and the underlying mechanisms, however, were barely reported. In this study, the effects of D-panthenol on human hair follicle cells, including dermal papilla cells (hDPCs) and outer root sheath cells (hORSCs), were investigated. D-panthenol enhanced the cell viability, increasing the cellular proliferation marker Ki67 in cultured hDPCs. The markers for apoptosis (Caspase3/9) and cell senescence (p21/p16), reported to be expressed in aged or resting phase follicles, were significantly reduced by D-panthenol. Anagen-inducing factors (ALP; β-catenin; versican), which trigger or elongate the anagen phase, were stimulated by D-panthenol. On the other hand, D-panthenol reduced TGF-β1 expressions in both mRNA and protein levels. The expression of VEGF, which is important for peripheral blood vessel activation; was up-regulated by D-panthenol treatment. In cultured hORSCs, cell proliferation and viability were enhanced, while the mRNA expression of cell senescence markers (p21/p16) was significantly down-regulated. The expressions of both VEGF and its receptor (VEGFR) were up-regulated by D-panthenol. In conclusion, our data suggest that the hair growth stimulating activity of D-panthenol was exerted by increasing the cell viability, suppressing the apoptotic markers, and elongating the anagen phase in hair follicles.

A method for culturing human hair follicle cells. (II). Plucked human hair follicles.

1988 ◽  
Vol 50 (2) ◽  
pp. 271-276 ◽  
Author(s):  
Ryuichiro KUWANA ◽  
Seiji ARASE ◽  
Yasushi SADAMOTO ◽  
Hideki NAKANISHI ◽  
Katsuyuki TAKEDA
Keyword(s):  
Hair Follicle ◽  
Human Hair ◽  
Hair Follicles ◽  
Follicle Cells ◽  
Human Hair Follicle

Epidermis reconstructed from the outer root sheath of human hair follicle. Effect of retinoic acid

1993 ◽  
Vol 285 (4) ◽  
pp. 197-204 ◽  
Author(s):  
M. -C. Lenoir-Viale ◽  
C. Galup ◽  
M. Darmon ◽  
B. A. Bernard
Keyword(s):  
Retinoic Acid ◽  
Hair Follicle ◽  
Human Hair ◽  
Human Hair Follicle ◽  
Outer Root Sheath ◽  
Root Sheath
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