CONNECTIVE TISSUE CHANGES IN THE RABBIT URINARY BLADDER AND URETER DURING PREGNANCY

ABSTRACT The urinary bladder and ureters from 8 normal and 40 pregnant rabbits were studied histologically, and also by acid glycosaminoglycan analysis. No morphological changes could be demonstrated. In the later stages of pregnancy the water content was found to be lowered, and a decrease in hexosamine and uronic acid contents in bladder walls was demonstrated on the 28th day of pregnancy. It is believed that the changes are due to a hormonal influence.

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EFFECT OF PREGNANCY ON THE RABBIT URINARY BLADDER AND URETER.

Acta Endocrinologica ◽

10.1530/acta.0.0570427 ◽

1968 ◽

Vol 57 (3) ◽

pp. 427-440

Author(s):

Finn Rasmussen

Keyword(s):

Urinary Bladder ◽

Connective Tissue ◽

Marked Reduction ◽

Significant Rise ◽

Hormone Production ◽

Bladder Tissue ◽

Acid Mucopolysaccharides ◽

Tissue Changes ◽

Healing Wounds ◽

Rabbit Urinary Bladder

ABSTRACT The connective tissue changes in the intact urinary bladder and ureteral tissues, and in healing urinary bladder wounds, were studied in pregnant and non-pregnant female rabbits. Pregnancy caused a significant rise in ureteral water content, but no significant alterations in intact bladder tissue. In the healing wounds, a marked reduction in the content of acid mucopolysaccharides and in the uptake of radiosulphate was observed from the seventh day after operation. At this time, the production of relaxin is known to increase rapidly. A possible relation between the lowered content of acid mucopolysaccharides and hormone production during pregnancy, is discussed.

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EFFECT OF ANDROGENS AND ANABOLIC STEROIDS ON RABBIT URINARY BLADDER AND URETER

Acta Endocrinologica ◽

10.1530/acta.0.0570414 ◽

1968 ◽

Vol 57 (3) ◽

pp. 414-426 ◽

Cited By ~ 5

Author(s):

Finn Rasmussen

Keyword(s):

Urinary Bladder ◽

Testosterone Propionate ◽

Morphological Changes ◽

Anabolic Steroids ◽

Experimental Period ◽

Hormone Treatment ◽

Collagen Concentration ◽

Healing Wounds ◽

Growth Promoting ◽

Rabbit Urinary Bladder

ABSTRACT The effect of testosterone propionate and methandrostenolone on the connective tissue components in intact bladder, ureter, and healing linear urinary bladder wounds was studied in male albino rabbits. No morphological changes due to hormone treatment was observed. Treatment with testosterone propionate caused a decrease in the content of water and acid mucopolysaccharides during most of the experimental period, which lasted for 28 days after the production of wounds, and decreased the collagen concentration 28 days after operation. Methandrostenolone showed a growth-promoting action as well as a dubious depressant effect on the water content in the healing wounds, but was without influence on the collagen and acid mucopolysaccharide contents.

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Effect of verapamil on cytoplasmic distribution of granules and microfilaments in amphibian urinary bladder

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100103681 ◽

1988 ◽

Vol 46 ◽

pp. 324-325

Author(s):

A.J. Mia ◽

L.X. Oakford ◽

T. Yorio

Keyword(s):

Urinary Bladder ◽

Water Flow ◽

Morphological Changes ◽

Granular Cell ◽

Cytosolic Calcium ◽

Calcium Storage ◽

Amphibian Urinary Bladder ◽

Vesicular Membrane ◽

High Concentrations ◽

Cytoskeletal System

The amphibian urinary bladder has been used as a ‘model’ system for studies of the mechanism of action of antidiuretic hormone (ADH) in stimulating transepithelial water flow. The increase in water permeability is accompanied by morphological changes that include the stimulation of apical microvilli, mobilization of microtubules and microfilaments and vesicular membrane fusion events . It has been shown that alterations in the cytosolic calcium concentrations can inhibit ADH transmembrane water flow and induce alterations in the epithelial cell cytomorphology, including the cytoskeletal system . Recently, the subapical granules of the granular cell in the amphibian urinary bladder have been shown to contain high concentrations of calcium, and it was suggested that these cytoplasmic constituents may act as calcium storage sites for intracellular calcium homeostasis. The present study utilizes the calcium antagonist, verapamil, to examine the effect of calcium deprivation on the cytomorphological features of epithelial cells from amphibian urinary bladder, with particular emphasis on subapical granule and microfilament distribution.

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AN UNUSUAL CASE OF EXOPHTHALMOS WITH GENERAL CONNECTIVE TISSUE CHANGES

Acta Endocrinologica ◽

10.1530/acta.0.xxxiii0613 ◽

1960 ◽

Vol XXXIII (IV) ◽

pp. 613-622 ◽

Cited By ~ 2

Author(s):

B.-A. Lamberg ◽

O. Wegelius ◽

B. Kuhlbäck ◽

C. Olin-Lamberg

Keyword(s):

Renal Failure ◽

Connective Tissue ◽

Beneficial Effect ◽

Muscle Tissue ◽

Clinical Picture ◽

Unusual Case ◽

Systemic Treatment ◽

Nasal Epithelium ◽

Tissue Changes ◽

Histochemical Examination

ABSTRACT A case is described of a man of 48, who presented a history and clinical picture of a solitary thyro-hypophysial syndrome with malignant exophthalmos but in which general connective tissue changes were found on histological and histochemical examination of the retrobulbar connective tissue and muscles, of the pretibial connective and muscle tissue and the nasal epithelium. The intraocular tension was increased. In addition, renal failure developed. The use of cortisol locally in the eyes had a beneficial effect on the eye syndrome. Systemic treatment with corticotrophin and prednisolone had an evident beneficial effect on the renal condition.

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