THE EFFECT OF EPINEPHRINE AND ISOPROTERENOL ON INSULIN SECRETION AND GLUCOSE UTILIZATION IN ISOLATED ISLETS OF LANGERHANS FROM MICE

1977 ◽  
Vol 84 (1) ◽  
pp. 105-114 ◽  
Author(s):  
Leif Sparre Hermann ◽  
Torsten Deckert
Keyword(s):  
Insulin Secretion ◽  
Islets Of Langerhans ◽  
Glucose Concentration ◽  
Glucose Utilization ◽  
Isolated Islets ◽  
Adrenergic Stimulation ◽  
Blocking Agents ◽  
Isolated Islets Of Langerhans ◽  
Low Glucose ◽  
Adrenergic Blocking

ABSTRACT The effect of epinephrine and isoproterenol in different concentrations and adrenergic blocking agents on glucose induced insulin secretion and glucose utilization was studied in isolated islets of Langerhans from mice. Epinephrine in physiological concentrations significantly inhibited the glucose induced insulin secretion. This effect was not mediated by a change in glucose utilization but involved α-adrenergic stimulation. Isoproterenol significantly stimulated the glucose induced insulin secretion but had no effect on glucose utilization. β-adrenergic stimulation by isoproterenol at low glucose concentration was not sufficient to stimulate insulin secretion. The results are discussed in relation to current theories on the mechanism of glucose induced insulin secretion.

scholarly journals Chromium-induced inhibition of insulin secretion from isolated Islets of Langerhans

Diabetologia ◽  
1980 ◽  
Vol 18 (3) ◽  
pp. 229-232 ◽  
Author(s):  
T. Ghafghazi ◽  
M. L. McDaniel ◽  
P. E. Lacy
Keyword(s):  
Insulin Secretion ◽  
Islets Of Langerhans ◽  
Isolated Islets ◽  
Isolated Islets Of Langerhans

Effect of Streptozotocin on Glucose-induced Insulin Secretion by Isolated Islets of Langerhans

Diabetes ◽  
1971 ◽  
Vol 20 (8) ◽  
pp. 513-518 ◽  
Author(s):  
P. Golden ◽  
L. Baird ◽  
W. J. Malaisse ◽  
F. Malaisse-Lagae ◽  
M. M. Walker
Keyword(s):  
Insulin Secretion ◽  
Islets Of Langerhans ◽  
Isolated Islets ◽  
Isolated Islets Of Langerhans

scholarly journals A species difference in nucleoside phosphorylase activity and inosine-stimulated insulin secretion in isolated islets of Langerhans

1977 ◽  
Vol 168 (3) ◽  
pp. 591-593 ◽  
Author(s):  
I L Campbell ◽  
K W Taylor
Keyword(s):  
Insulin Secretion ◽  
Insulin Release ◽  
Islets Of Langerhans ◽  
Species Differences ◽  
Species Difference ◽  
Isolated Islets ◽  
Phosphorylase Activity ◽  
Nucleoside Phosphorylase ◽  
Isolated Islets Of Langerhans

Inosine is a potent simulant of insulin release from rat but not from rabbit islets of Langerhans. Further investigation showed that nucleoside phosphorylase activity is exceptionally low in rabbit islets. The ability of inosine to promote insulin release seems to be related to islet nucleoside phosphorylase activity, which can display marked species differences.

Effect of a local anesthetic upon calcium uptake and insulin secretion by isolated islets of langerhans

Life Sciences ◽  
1971 ◽  
Vol 10 (8) ◽  
pp. 445-448 ◽  
Author(s):  
Guy R. Brisson ◽  
Frédéric Camu ◽  
Francine Malaisse-Lagae ◽  
Willy J. Malaisse
Keyword(s):  
Insulin Secretion ◽  
Islets Of Langerhans ◽  
Local Anesthetic ◽  
Calcium Uptake ◽  
Isolated Islets ◽  
Isolated Islets Of Langerhans

INSULIN SECRETORY RESPONSE OF ISOLATED ISLETS OF LANGERHANS IN PREGNANT RATS: EFFECTS OF DIETARY RESTRICTION

1974 ◽  
Vol 62 (1) ◽  
pp. 137-143 ◽  
Author(s):  
I. C. GREEN ◽  
K. W. TAYLOR
Keyword(s):  
Insulin Secretion ◽  
Food Intake ◽  
Islets Of Langerhans ◽  
Secretory Response ◽  
Pregnant Rats ◽  
Additional Food ◽  
Daily Food ◽  
Isolated Islets Of Langerhans ◽  
Low Glucose ◽  
In Pregnancy

SUMMARY The effects of diet on the altered insulin secretory responses of islets of Langerhans of pregnant rats have been investigated. The daily food intake of pregnant rats was found to exceed that of control non-pregnant rats by 20% on average. Depriving pregnant rats of this additional food resulted in an alteration in the pattern of insulin secretion seen in pregnancy, such that the sensitivity to stimulation by low glucose concentrations was abolished. The contribution made by different components of the diet to the secretory response in pregnancy was investigated. When additional carbohydrate, though not protein, was fed to pregnant rats on a restricted food intake, the sensitivity of the islets to glucose stimulation was restored. It was concluded that the quantity and in particular the carbohydrate content of food eaten by pregnant rats exerts an important influence on the changes in insulin secretion in pregnancy.

Effects of Age and of Fasting on the Responsiveness of the Insulin-Secreting Mechanism of the Islets of Langerhans to Glucose

1975 ◽  
Vol 53 (5) ◽  
pp. 716-725 ◽  
Author(s):  
J. A. Coddling ◽  
A. Kalnins ◽  
R. E. Haist
Keyword(s):  
Insulin Secretion ◽  
Islets Of Langerhans ◽  
Isolated Islets ◽  
Insulin Content ◽  
Prolonged Fasting ◽  
Threshold Levels ◽  
Isolated Islets Of Langerhans ◽  
Insulin Responsiveness ◽  
Glucose Stimulated Insulin Secretion ◽  
Feeding And Fasting

Insulin responsiveness to glucose of isolated islets of Langerhans was studied in 'younger' and 'older' rats after feeding and fasting for various lengths of time. In 'younger' rats, after prolonged fasting (168 h) the threshold for glucose-stimulated insulin secretion was increased. This was not evident in islets from 'younger' rats fasted for 48 or 89 h. Reductions in increments of insulin secretion with increments in glucose, in the maximum insulin secreted and in the total extractable insulin of the islets were apparent after fasting for 48, 89 and 168 h as compared with islets from fed rats. In 'older' rats, prolonged fasting caused an increase in the threshold for glucose-stimulated insulin secretion, reduced incremental insulin secretion, reduced maximum insulin secretion and reduced total extractable insulin. However, the responses of islets from fed 'older' rats were similar to those of fasted (168 h) 'younger' rats. The threshold levels were similar, and there were no significant differences between increments in insulin secretion, maximum insulin secretion and insulin content of the islets. These experiments show that the responsiveness of islets of Langerhans in rats can be altered by age and fasting.

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