INCIDENCE OF CONGENITAL HYPOTHYROIDISM. A RETROSPECTIVE STUDY COMPARING NEONATAL SCREENING AND CLINICAL DIAGNOSIS.

1983 ◽  
Vol 104 (2_Supplb) ◽  
pp. S58-S61
Author(s):  
A Larsson ◽  
L Haganfeldt ◽  
J Aim ◽  
K Lundberg
Keyword(s):  
Retrospective Study ◽  
Clinical Diagnosis ◽  
Congenital Hypothyroidism ◽  
Neonatal Screening

Pubertal development and adult height in patients with congenital hypothyroidism detected by neonatal screening in southern Brazil

2020 ◽  
Vol 33 (11) ◽  
pp. 1449-1455
Author(s):  
Suzana Nesi-França ◽  
Rodrigo B. Silveira ◽  
Juliana Cristina R. Rojas Ramos ◽  
Adriane A. Cardoso-Demartini ◽  
Monica N. Lima Cat ◽  
...  
Keyword(s):  
Congenital Hypothyroidism ◽  
Neonatal Screening ◽  
Adult Height ◽  
Screening Program ◽  
Pubertal Development ◽  
Z Score ◽  
Normal Range ◽  
Adequate Treatment ◽  
Increased Risk ◽  
Puberty Onset

AbstractObjectivesAdequate treatment of congenital hypothyroidism (CH) is required for normal growth and sexual development. To evaluate pubertal development in patients with permanent CH detected by a statewide Neonatal Screening Program of Paraná and, secondly, to evaluate adult height (AH) in a subgroup of patients.MethodsClinical, laboratory, and auxological data obtained from medical records of 174 patients (123 girls).ResultsMedian chronological age (CA) at treatment initiation was 24 days, and mean initial levothyroxine dose was 11.7 ± 1.9 μg/kg/day; mean CA at puberty onset was 11.5 ± 1.3 years (boys) and 9.7 ± 1.2 years (girls); mean CA in girls who underwent menarche (n=81) was 12.1 ± 1.1 years. Thyroid-stimulating hormone (TSH) values above the normal range were observed in 36.4% of the boys and 32.7% of the girls on puberty onset, and in 44.6% around menarche. Among 15 boys and 66 girls who had reached the AH, the median height z-score value was significantly greater than the target height (TH) z-score value in boys (p=0.01) and in girls (p<0.001). Boys with normal TSH values at puberty onset had greater mean AH z-score compared with boys with TSH values above the normal range (p=0.04).ConclusionsIn this group, pubertal development in girls with CH was not different from that reported in healthy girls in the general Brazilian population. Boys with higher TSH at puberty onset may have an increased risk of not reaching their potential height compared with those with normal TSH during this period. In a subgroup who attained AH, the median AH z-score was greater than the median TH z-score.

A Retrospective Study of 95 Women With a Clinical Diagnosis of Genital Lichen Planus

2010 ◽  
Vol 14 (4) ◽  
pp. 323-328 ◽  
Author(s):  
Lindy A.M. Santegoets ◽  
Theo J.M. Helmerhorst ◽  
Willem I. van der Meijden
Keyword(s):  
Retrospective Study ◽  
Lichen Planus ◽  
Clinical Diagnosis

scholarly journals Neonatal Screening for Congenital Hypothyroidism with Focus on Developing an Indian Screening Programme

2016 ◽  
Vol 12 (2) ◽  
pp. 99
Author(s):  
Jubbin Jagan Jacob ◽  
Keyword(s):  
Congenital Hypothyroidism ◽  
Neonatal Screening ◽  
Resource Constraints ◽  
Screening Programme ◽  
Standard Of Care ◽  
Neurological Impairment ◽  
Current Understanding ◽  
Hormone Deficiency ◽  
Levothyroxine Replacement ◽  
Long Term Follow Up

Neonatal screening for congenital hypothyroidism, along with eradication of iodine deficiency in large parts of the world, has made it possible to prevent the development of permanent neurological impairment due to thyroid hormone deficiency in the developing brain. The first successful screening programme was demonstrated in Canada in 1973 and since then it has been standard of care in most developed societies. In India there is no national programme for neonatal screening, and screening is only done in selected larger hospitals on newborns whose parents fund it. This review summarises the current understanding of the various strategies for newborn screening that could potentially be employed in India with resource constraints. Once a case is detected, the further evaluation and determination of etiology is summarised. Treatment and long term follow-up with levothyroxine replacement is also described in detail as per current understanding.

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