Middle-aged women with Turner's syndrome. Medical status, hormonal treatment and social life

Abstract. A study of 49 middle-aged (>35 years old) women with Turner's syndrome was performed to evaluate medical status, hormonal treatment and social life. Most of the women lived a normal social life in stable relationships and all were employed. Some had adopted children and 4 had children of their own. They had all been informed about Turner's syndrome at time of diagnosis, but after the induced puberty they did not know who to turn to with their variety of medical problems. They were healthy except for reduced hearing, which in many cases required hearing aid. Elevated liver enzymes were found in almost all the women. The mechanism behind this finding is unclear, but it does not seem to imply severe liver damage why the indicated estrogen therapy should not be withdrawn from these women. Today amniocentesis and chorionic villus biopsies are commonly used to detect chromosome abnormalities. It is our duty as counsellors to give adequate information on the prognosis of a specific finding in the fetus to help future parents in their decision.

Download Full-text

DIAGNOSIS OF MOSAIC TURNER'S SYNDROME IN A MIDDLE-AGED WOMAN

Endocrine Practice ◽

10.4158/ep.12.5.593 ◽

2006 ◽

Vol 12 (5) ◽

pp. 593-594 ◽

Cited By ~ 1

Author(s):

Tracy L. Setji ◽

Kathryn P. Lowry ◽

Ann J. Brown

Keyword(s):

Turner's Syndrome ◽

Turner’S Syndrome ◽

Middle Aged ◽

Aged Woman ◽

Middle Aged Woman

Download Full-text

Turner's Syndrome: Approach to Diagnosis and Treatment

Nepal Journal of Obstetrics and Gynaecology ◽

10.3126/njog.v13i3.23476 ◽

2018 ◽

Vol 13 (3) ◽

pp. 61-62

Author(s):

Sadhana Sah ◽

Ganesh Dangal ◽

Aruna Karki ◽

Hema Pradhan ◽

Ranjana Shrestha ◽

...

Keyword(s):

Short Stature ◽

Estrogen Therapy ◽

Tanner Stage ◽

Breast Development ◽

Primary Amenorrhea ◽

Turner's Syndrome ◽

Turner’S Syndrome ◽

Secondary Sexual Characteristics ◽

Karyotypic Abnormality ◽

Sexual Characteristics

Turner's syndrome is the most common karyotypic abnormality causing gonadal failure and primary amenorrhea. It is characterized by short stature and absence of secondary sexual characteristics. It is diagnosed by increased plasma FSH and LH level with low level of estrogen i.e. hypergonadotrophic hypogonadism. Ultrasound abdomen reveals streak ovaries and atrophic uterus. Karyotype confirms the diagnosis of Turner's syndrome (45XO). We present here a 15 years girl who presented with primary amenorrhea with short stature with breast development corresponds to Tanner stage I. Her FSH was raised. Ultrasound abdomen showed uterine agenesis and streak ovaries. Karyotype showed 45XO which confirmed the diagnosis of Turner's syndrome. She is now on estrogen therapy and her height has increased and breast development corresponds to Tanner stage II. Keywords: hypergonadotrophic hypogonadism, primary amenorrhea, Turner's syndrome

Download Full-text

Estrogen Therapy in Turner's Syndrome

Pediatrics International ◽

10.1111/j.1442-200x.1992.tb00950.x ◽

1992 ◽

Vol 34 (2) ◽

pp. 195-205 ◽

Cited By ~ 3

Author(s):

Gordon B. Cutler ◽

Judith Levine Ross

Keyword(s):

Estrogen Therapy ◽

Turner's Syndrome ◽

Turner’S Syndrome

Download Full-text

Bone mineral density in middle-aged women with Turner's syndrome

Acta Endocrinologica ◽

10.1530/eje.0.1320047 ◽

1995 ◽

Vol 132 (1) ◽

pp. 47-52 ◽

Cited By ~ 30

Author(s):

Lisskulla Sylvén ◽

Kerstin Hagenfeldt ◽

Hans Ringertz

Keyword(s):

Bone Mineral Density ◽

Body Fat ◽

Bone Mineral ◽

Turner's Syndrome ◽

Turner’S Syndrome ◽

Middle Aged ◽

Mineral Density ◽

Percentage Body Fat ◽

Significant Difference ◽

Total Body

Sylvén L, Hagenfeldt K, Ringertz H. Bone mineral density in middle-aged women with Turner's syndrome. Eur J Endrocrinol 1995;132:47–52. ISSN 0804–4643 Bone mineral density (BMD), bone mineral content and body composition were determined in 47 middle-aged (mean age 47.9 ± 1.1 years) women with Turner's syndrome. Bone mineral density was measured in the forearm, femoral neck and total body. The women investigated had a BMD lower than the normal mean. When expressed as Z scores (individual values compared to normal reference data matched for age, weight and sex), the median Z score of the total body was −1.23. When comparing women with the karyotype 45,X and mosaic women, the latter showed a higher BMD in all sites of measurement. Duration of hormonal replacement therapy (HRT) differed significantly between the mosaic and the 45,X women, with a longer duration in the mosaic group (20.7 ± 2 vs 12.1 ± 2.6 years; p < 0.01). The duration of HRT was found to be the more important factor to maintain bone mass, not the karyotype. Bone mineral density increased with years of HRT but not until after > 20 years of HRT could a significant difference be shown between the women with HRT ≤ 20 years and those with HRT > 20 years. No correlation was found between BMD and body weight, body fat or percentage body fat. Whether the osteopenia found in women with Turner's syndrome is similar to that found postmenopausally or is a specific form related to the chromosome aberration remains to be investigated further. The present data support a relation to estrogen deficiency. Lisskulla Sylvén, Department of Woman and Child Health, Division for Obstetrics & Gynecology, Karolinska Hospital, S-171 76 Stockholm, Sweden

Download Full-text