Microtomography analysis of bone formation in calvarial defects filled with gelatin sponge or fibrin glue

The purpose of this study was to evaluate the effects of collagen membrane coated with PLGA on bone regeneration in rat calvarial defect. Five groups of 10 animals each received either collagen membrane coated with 0.5%, 1%, 3% concentration of PLGA, collagen membrane only or surgical control. Each group of animals was healed into 2 healing periods of 2(5 animals) and 8(5 animals)weeks and histologic and histomorphometric analysis were done. The results of the following study revealed that surgical implantation of collagen membranes coated with PLGA enhanced local bone formation at both 2 and 8 weeks independent of different PLGA concentrations. In conclusion, collagen membrane coated with PLGA shows a significant bone formation behavior irrespective of their concentration.

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Biologic properties of nano-hydroxyapatite: An in vivo study of calvarial defects, ectopic bone formation and bone implantation

Bio-Medical Materials and Engineering ◽

10.3233/bme-141244 ◽

2015 ◽

Vol 25 (1) ◽

pp. 25-38 ◽

Cited By ~ 5

Author(s):

Kang-Mi Pang ◽

Jeong-Keun Lee ◽

Young-Kwon Seo ◽

Soung-Min Kim ◽

Myung-Jin Kim ◽

...

Keyword(s):

Bone Formation ◽

Ectopic Bone Formation ◽

In Vivo Study ◽

Ectopic Bone ◽

Calvarial Defects

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Sequential Treatment with SDF-1 and BMP-2 Potentiates Bone Formation in Calvarial Defects

Tissue Engineering Part A ◽

10.1089/ten.tea.2014.0571 ◽

2015 ◽

Vol 21 (13-14) ◽

pp. 2125-2135 ◽

Cited By ~ 23

Author(s):

Hee-Don Hwang ◽

Jung-Tae Lee ◽

Jeong-Tae Koh ◽

Hong-Moon Jung ◽

Heon-Jin Lee ◽

...

Keyword(s):

Bone Formation ◽

Sequential Treatment ◽

Calvarial Defects

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Effect of Particle Size on New Bone Formation In Vivo Using Calcium Phopshate Glass

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.330-332.165 ◽

2007 ◽

Vol 330-332 ◽

pp. 165-168

Author(s):

Hyun Ju Moon ◽

Racquel Z. LeGeros ◽

Kyoung Nam Kim ◽

Kwang Mahn Kim ◽

Seong Ho Choi ◽

...

Keyword(s):

Particle Size ◽

Calcium Phosphate ◽

Bone Formation ◽

Phosphate Glass ◽

Glass Powder ◽

New Bone Formation ◽

Sprague Dawley ◽

Constant Weight ◽

Calvarial Defects

The purpose of this study was to compare the bone regenerative effect of calcium phosphate glass according to the particle size in vivo. We prepared two different sizes, that is 400 μm and 40 μm, of calcium phosphate glass powder using the system CaO-CaF2-P2O5-MgO-ZnO. Critical-sized calvarial defects were created in 60 male Sprague-Dawley rats. The animals were divided into 3 groups of 20 animals each. Each defect was filled with a constant weight of 0.5 g calcium phosphate glass powder mixed with saline. As controls, the defect was left empty. The rats were sacrificed 2 or 8 weeks after postsurgery, and the results were evaluated using histological as well as histomorphometrical studies. The particle size of the calcium phosphate was crucial; 400 μm particles promoted new bone formation, while 40 μm particles inhibited it because of severe inflammation.

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