The characteristics of bone mineral density, erosive and destructive changes in joints of hands and feet, vertebral deformities in patients with rheumatoid arthritis

2014 ◽  
Author(s):  
Elena Petrova ◽  
Irina Dydykina ◽  
Aleksandr Smirnov ◽  
Marina Podvorotova ◽  
Elena Taskina ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Vertebral Deformities ◽  
Hands And Feet

The characteristics of bone mineral density, erosive and destructive changes in joints of hands and feet, vertebral deformities in patients with rheumatoid arthritis

2014 ◽  
Author(s):  
Elena Petrova ◽  
Irina Dydykina ◽  
Aleksandr Smirnov ◽  
Marina Podvorotova ◽  
Elena Taskina ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Vertebral Deformities ◽  
Hands And Feet

Radiographic damage associated with low bone mineral density and vertebral deformities in rheumatoid arthritis: The Oslo-Truro-Amsterdam (OSTRA) collaborative study

2003 ◽  
Vol 49 (2) ◽  
pp. 209-215 ◽  
Author(s):  
Mariette C. Lodder ◽  
Glenn Haugeberg ◽  
Willem F. Lems ◽  
Till Uhlig ◽  
Ragnhild E. Orstavik ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Collaborative Study ◽  
Mineral Density ◽  
Radiographic Damage ◽  
Vertebral Deformities ◽  
Low Bone Mineral Density

Vertebral deformities in 229 female patients with rheumatoid arthritis: Associations with clinical variables and bone mineral density

2003 ◽  
Vol 49 (3) ◽  
pp. 355-360 ◽  
Author(s):  
Ragnhild E. Ørstavik ◽  
Glenn Haugeberg ◽  
Till Uhlig ◽  
Jan A. Falch ◽  
Johan I. Halse ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Clinical Variables ◽  
Vertebral Deformities ◽  
Female Patients

scholarly journals Accelerated hand bone mineral density loss is associated with progressive joint damage in hands and feet in recent-onset rheumatoid arthritis

2010 ◽  
Vol 12 (3) ◽  
pp. R96 ◽  
Author(s):  
Melek Güler-Yüksel ◽  
Naomi B Klarenbeek ◽  
Yvonne PM Goekoop-Ruiterman ◽  
Jeska K de Vries-Bouwstra ◽  
Sjoerd M van der Kooij ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Joint Damage ◽  
Mineral Density ◽  
Bone Mineral Density Loss ◽  
Recent Onset ◽  
Hands And Feet ◽  
Progressive Joint Damage

scholarly journals Study of local and generalized bone loss in patients with rheumatoid arthritis

2019 ◽  
Vol 57 (3) ◽  
pp. 328-332
Author(s):  
I. S. Dydykina ◽  
P. O. Kozhevnikova
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Loss ◽  
Chronic Inflammation ◽  
Bone Mineral ◽  
Mineral Density ◽  
Bone Changes ◽  
Hands And Feet ◽  
The Relationship ◽  
Peripheral Skeleton

Chronic inflammation in rheumatoid arthritis (RA) is accompanied by local (periarticular osteoporosis) and generalized loss of bone mineral density in the axial and peripheral skeleton. The paper discusses the relationship between local and generalized bone loss and the contribution of various factors to bone changes. Information about the contribution of age at the onset of RA to the progression of destructive changes in the hands and feet and the rate of generalized bone loss in the axial and peripheral skeleton are contradictory.

Change in bone mineral density with high-dose prednisone in patients with rheumatoid arthritis

2016 ◽  
Author(s):  
Linda Rasch ◽  
Tuyl Lilian van ◽  
Martijn Kremer ◽  
Irene Bultink ◽  
Maarten Boers ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
High Dose ◽  
Mineral Density ◽  
Dose Prednisone

The influence of the 24-month treatment with anti-CD20 antibodies (rituximab) on bone mineral density in patients with rheumatoid arthritis

2014 ◽  
Author(s):  
Polina Dydykina ◽  
Irina Dydykina ◽  
Anna Devyataikina ◽  
Galina Lukina ◽  
Alexandr Smirnov ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Anti Cd20 ◽  
Cd20 Antibodies

FRI0077 Factors Predicting Change in Bone Mineral Density in Patients with Rheumatoid Arthritis: the Tomorrow Study: Table 1

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 409.1-409
Author(s):  
M. Tada ◽  
T. Koike ◽  
K. Inui ◽  
Y. Sugioka ◽  
K. Mamoto ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density

scholarly journals P129 Predictors of low bone mineral density in rheumatoid arthritis

Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_1) ◽  
Author(s):  
Malika A Swar ◽  
Marwan Bukhari
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Bone Mineral Density ◽  
Family History ◽  
Bone Loss ◽  
Femoral Neck ◽  
Bone Mineral ◽  
Fragility Fracture ◽  
Mineral Density ◽  
History Of

Abstract Background/Aims  Osteoporosis (OP) is an extra-articular manifestation of rheumatoid arthritis (RA) that leads to increased fracture susceptibility due to a variety of reasons including immobility and cytokine driven bone loss. Bone loss in other populations has well documented risk factors. It is unknown whether bone loss in RA predominantly affects the femoral neck or the spine. This study aimed to identify independent predictors of low bone mineral density (BMD) in patients RA at the lumbar spine and the femoral neck. Methods  This was a retrospective observational cohort study using patients with Rheumatoid arthritis attending for a regional dual X-ray absorptiometry (DEXA) scan at the Royal Lancaster Infirmary between 2004 and 2014. BMD in L1-L4 in the spine and in the femoral neck were recorded. The risk factors investigated were steroid use, family history of osteoporosis, smoking, alcohol abuse, BMI, gender, previous fragility fracture, number of FRAX(tm) risk factors and age. Univariate and Multivariate regression analysis models were fitted to explore bone loss at these sites using BMD in g/cm2 as a dependant variable. . Results  1,527 patients were included in the analysis, 1,207 (79%) were female. Mean age was 64.34 years (SD11.6). mean BMI was 27.32kg/cm2 (SD 5.570) 858 (56.2%) had some steroid exposure . 169(11.1%) had family history of osteoporosis. fragility fracture history found in 406 (26.6%). 621 (40.7%) were current or ex smokers . There was a median of 3 OP risk factors (IQR 1,3) The performance of the models is shown in table one below. Different risk factors appeared to influence the BMD at different sites and the cumulative risk factors influenced BMD in the spine. None of the traditional risk factors predicted poor bone loss well in this cohort. P129 Table 1:result of the regression modelsCharacteristicB femoral neck95% CIpB spine95%CIpAge at scan-0.004-0.005,-0.003<0.01-0.0005-0.002,0.00050.292Sex-0.094-0.113,-0.075<0.01-0.101-0.129,-0.072<0.01BMI (mg/m2)0.0080.008,0.0101<0.010.01130.019,0.013<0.01Fragility fracture-0.024-0.055,0.0060.12-0.0138-0.060,0.0320.559Smoking0.007-0.022,0.0350.650.0286-0.015,0.0720.20Alcohol0.011-0.033,0.0 5560.620.0544-0.013,0.1120.11Family history of OP0.012-0.021,0.0450.470.0158-0.034,0.0650.53Number of risk factors-0.015-0.039,0.0080.21-0.039-0.075,-0.0030.03steroids0.004-0.023,0.0320.030.027-0.015,0.0690.21 Conclusion  This study has shown that predictors of low BMD in the spine and hip are different and less influential than expected in this cohort with RA . As the FRAX(tm) tool only uses the femoral neck, this might underestimate the fracture risk in this population. Further work looking at individual areas is ongoing. Disclosure  M.A. Swar: None. M. Bukhari: None.

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