Dietary calcium intake influences the relationship between serum 25 hydroxyvitamin D concentrations and Parathyroid hormone

2015 ◽  
Author(s):  
Rubina Mandlik ◽  
Prerna Patel ◽  
Pinal Patel ◽  
Ashish Patel ◽  
Supriya Phanse-Gupte ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Calcium Intake ◽  
Dietary Calcium ◽  
Dietary Calcium Intake ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
The Relationship

Dietary calcium intake influences the relationship between serum 25-hydroxyvitamin D3 (25OHD) concentration and parathyroid hormone (PTH) concentration

2015 ◽  
Vol 101 (4) ◽  
pp. 316-319 ◽  
Author(s):  
Prerna Patel ◽  
M Zulf Mughal ◽  
Pinal Patel ◽  
Bhrugu Yagnik ◽  
Neha Kajale ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Calcium Intake ◽  
Dietary Calcium ◽  
Dietary Calcium Intake ◽  
Western India ◽  
Serum 25Ohd ◽  
25Ohd Concentration ◽  
Serum Pth ◽  
The Relationship ◽  
Apparently Healthy

ObjectivesTo investigate whether dietary calcium intake will modify the relationship between serum 25-hydroxyvitamin D3 (25OHD) with intact serum parathyroid hormone (PTH) concentrations in apparently healthy Indian adolescents.Study designCross-sectional study.Setting and participantsApparently healthy adolescents aged 10–14 years (n=181), from Gujarat, western India. Study conducted from January 2012 to March 2014.MethodsSerum 25OHD concentrations and intact serum PTH concentrations (both using chemiluminescent microparticle immunoassay) were measured. Diet was recorded through 24 h diet recall and calcium intake was computed (C-diet V.2.1). To assess relationship between 25OHD and PTH, data were dichotomised according to median calcium intakes (520 mg/day) and relationship between serum 25OHD and PTH in the two subgroups was plotted.ResultsSubjects with calcium intakes above median (>520 mg/day) had lower intact serum PTH values for given serum 25OHD concentration while those with calcium intakes below median (<520 mg/day) had higher intact serum PTH values for given serum 25OHD concentration. Serum 25OHD concentration was negatively correlated with intact serum PTH concentration at lower as well as higher calcium intakes (r=− 0.606 and −0.483, respectively, p<0.01 for both). Using a regression analysis, predicted values for intact serum PTH concentration for the given serum 25OHD concentrations were plotted. The plot revealed a negative shift with increasing calcium intake.ConclusionsDietary calcium intake modifies the relationship between serum 25OHD concentrations and intact serum PTH concentrations. Thus, dietary calcium intake should be taken into account when assessing an individual's vitamin D status.

Serum 25-Hydroxyvitamin D, Dietary Calcium Intake, and Distal Colorectal Adenoma Risk

2001 ◽  
Vol 39 (1) ◽  
pp. 35-41 ◽  
Author(s):  
A. Joan Levine ◽  
Janice M. Harper ◽  
Carolyn M. Ervin ◽  
Ya-Hua Chen ◽  
Elizabeth Harmon ◽  
...  
Keyword(s):  
Colorectal Adenoma ◽  
Calcium Intake ◽  
Dietary Calcium ◽  
Dietary Calcium Intake ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Adenoma Risk

scholarly journals Dietary Calcium Intake and Hypertension: Importance of Serum Concentrations of 25-Hydroxyvitamin D

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 911 ◽  
Author(s):  
Nakamura ◽  
Tsujiguchi ◽  
Hara ◽  
Kambayashi ◽  
Miyagi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Calcium Intake ◽  
Dietary Calcium ◽  
Dietary Vitamin ◽  
Dietary Calcium Intake ◽  
Serum Concentrations ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
25 Hydroxyvitamin D ◽  
Dietary Vitamin D

The relationship among dietary calcium, hypertension and vitamin D status currently remains unclear. This population-based cross-sectional study examined the association between dietary calcium intake and hypertension and the influence of serum concentrations of 25-hydroxyvitamin D [25(OH)D] in Japanese subjects. A total of 619 subjects aged from 40 years were recruited. Dietary intake was measured using a validated brief self-administered diet history questionnaire. Hypertension was defined as the use of antihypertensive medication or a blood pressure of 140/90 mmHg. Serum concentrations of 25(OH)D were used as the biomarker of vitamin D status. The prevalence of hypertension and low serum 25(OH)D levels (<20 ng/mL) were 55 and 32%, respectively. Dietary calcium intake inversely correlated with hypertension in subjects with serum 25(OH)D levels higher than 20 ng/mL (OR: 0.995; 95% CI: 0.991, 0.999) but it was not significant in those with serum 25(OH)D levels of 20 ng/mL or lower. Furthermore, dietary vitamin D intake correlated with serum concentrations of 25(OH)D after adjustments for various confounding factors. The present results demonstrate that the regular consumption of calcium may contribute to the prevention and treatment of hypertension in subjects with a non-vitamin D deficiency and also that dietary vitamin D intake may effectively prevents this deficiency.

Serum Parathyroid Hormone in Healthy Japanese Women in Relation to Serum 25-Hydroxyvitamin D

2000 ◽  
Vol 70 (6) ◽  
pp. 287-292 ◽  
Author(s):  
Kazutoshi Nakamura ◽  
Mitsue Nashimoto ◽  
Yasushi Hori ◽  
Masaharu Yamamoto
Keyword(s):  
Parathyroid Hormone ◽  
Healthy Adult ◽  
Japanese Women ◽  
Normal Serum ◽  
Adult Women ◽  
Serum Parathyroid Hormone ◽  
Intact Pth ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
The Relationship

The aim of this work was to clarify levels of serum parathyroid hormone (PTH) in healthy adult women and to study the relationship between PTH and 25-hydroxyvitamin D [25(OH)D]. One hundred sixty-nine healthy women aged 40 years or older in a community were studied. The average age of the subjects was 65.3 years (SD 8.2). All subjects had normal serum creatinine levels. Serum intact PTH and 25(OH)D were measured in these subjects. The mean intact PTH concentration was 2.19 pmol/A (SD 1.02). High intact PTH levels above the reference range were observed in four women (2.4%), all of whom were aged 70 years or older. Intact PTH increased with age with a correlation coefficient of 0.192 (p = 0.013). However, there was no correlation (r = –0.125, p = 0.105) between intact PTH and 25(OH)D whose concentrations were more than 37.5 nmol/l. In conclusion, PTH levels of healthy adult Japanese women are lower than previous reports from Western countries, which may be due to the high 25(OH)D levels of the present subjects and/or an ethnic difference. In addition, there is no association between serum 25(OH)D and PTH levels in this Japanese population, supporting a cutoff level of 25(OH)D less than 37.5 nmol/l for the elevated PTH level.

The effect of dietary calcium intake of ewes in pregnancy on their Ca and phosphorus metabolism in lactation

1978 ◽  
Vol 39 (1) ◽  
pp. 213-218 ◽  
Author(s):  
G. D. Braithwaite
Keyword(s):  
Calcium Intake ◽  
Dietary Calcium ◽  
Dietary Calcium Intake ◽  
Phosphorus Metabolism ◽  
Irreversible Loss ◽  
Deficient Diet ◽  
Milk Fever ◽  
Rate Of Absorption ◽  
The Relationship ◽  
In Pregnancy

1. A combination of a mineral balance and a radioactive technique has been used to study the effect of the dietary calcium intake of ewes in pregnancy on their Ca and phosphorus metabolism in lactation.2. Ewes which had received a Ca-deficient diet in pregnancy absorbed Ca at a greater rate and with a greater efficiency in early lactation than did the control animals, which had received an adequate Ca intake in pregnancy. The apparent absorption of P was also higher in the Ca-deficient sheep.3. Since both groups of sheep received the same high Ca intake in lactation, the increased rate of absorption of Ca must have resulted from an increased rate of active transport rather than an increased rate of diffusion.4. Retention of both Ca and P was positive in the Ca-deficient ewes but negative in the control ewes. This difference in retention reflected a difference in bone metabolism.5. The maximum rate of absorption possible, which is equal to the rate of irreversible loss of Ca from the rapidly exchangeable pool, was much greater in the Ca-deficient lactating ewes than was previously found in Ca-deficient wethers. This difference is due to the additional pathway of loss of Ca in the milk of the lactating animals.6. The relationship between these findings and the prevention of milk fever in dairy cows by manipulation of the dietary Ca intake is discussed.

scholarly journals Associations of Sun Exposure with 25-Hydroxyvitamin D and Parathyroid Hormone Levels in a Cohort of Hypertensive Patients: The Graz Endocrine Causes of Hypertension (GECOH) Study

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Stefan Pilz ◽  
Katharina Kienreich ◽  
Daniel Stückler ◽  
Andreas Meinitzer ◽  
Andreas Tomaschitz
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Scalp Hair ◽  
Sun Exposure ◽  
Hypertensive Patients ◽  
Hydroxyvitamin D ◽  
Outdoor Sports ◽  
25 Hydroxyvitamin D ◽  
Relationship Of ◽  
The Relationship

Sunlight-induced vitamin D, synthesis in the skin is the major source of vitamin D, but data on the relationship of sun-related behaviour with vitamin D and parathyroid hormone (PTH) levels are relatively sparse. We evaluated whether habitual sun exposure is associated with 25-hydroxyvitamin D (25[OH]D) and PTH levels and whether there exist seasonal variations. We examined 111 hypertensive patients in Austria (latitude 47° N). Frequent sunbathing at home and outdoor sports were associated with higher 25(OH)D levels (P<0.05for both). Red or blond scalp hair as a child, memory of sunburns, preferring sunbathing, frequent stays on the beach or in open-air pools, and solarium use were associated with lower PTH levels (P<0.05for all). Multiple linear regression analyses including age, sex, and body mass index showed that sun exposure score was significantly associated with 25(OH)D (betacoefficient=0.27;P=0.004) and by trend with PTH (betacoefficient=−0.16;P=0.09). These associations were more prominent in summer in which 25(OH)D levels were significantly higher compared to winter. Translation of these findings into recommendations for the prevention and treatment of vitamin D deficiency remains a challenge for the future.

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