Evaluating the natural history of subcutaneous fat necrosis

Background. Subcutaneous fat necrosis (SFN) is a form of transient panniculitis that presents commonly in infants with a history of perinatal insult, particularly hypothermia. It is characterized by subcutaneous nodules and plaques that appear over bony prominences on cheeks, shoulders, buttock, and thighs. SFN is usually associated with various complications including hypercalcemia, thrombocytopenia, hypertriglyceridemia, and hyperglycemia. Case Presentation. We present a unique case of a female infant with a history of maternal chorioamnionitis who presented with SFN at 11 days of life with thrombocytosis. The platelet count decreased during the hospital stay, and thrombocytosis resolved over the course of the next two weeks. She did not have any other hematological or metabolic abnormalities associated with SFN. Conclusion. Infants with perinatal stress are at increased risk of developing SFN during the first month of life. Infants with a diagnosis of SFN should be monitored closely for various hematological and metabolic abnormalities that can have serious consequences.

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Subcutaneous Fat Necrosis of the Newborn With Initial Hypocalcemia and Familial Recurrence: A Case Report

Journal of Cutaneous Medicine and Surgery ◽

10.1177/1203475417733459 ◽

2017 ◽

Vol 22 (2) ◽

pp. 223-225 ◽

Cited By ~ 1

Author(s):

Amelia Kellar ◽

Jennifer Aileen Tangtatco ◽

Miriam Weinstein ◽

Natasha Saunders

Keyword(s):

Case Report ◽

Perinatal Asphyxia ◽

Subcutaneous Fat ◽

Fat Necrosis ◽

Extensive Disease ◽

Subcutaneous Fat Necrosis ◽

Severe Hypercalcemia ◽

Familial Association ◽

History Of ◽

Posterior Trunk

Subcutaneous fat necrosis of the newborn (SFNN) is a rare disorder characterised by indurated plaques or nodules with or without erythema, typically distributed over the cheeks, extremities, posterior trunk, buttocks, and thighs, and appears during the first 2 weeks of life. It is commonly associated with perinatal asphyxia and, while usually self-limited, can lead to severe hypercalcemia. There is no known familial association. The present article describes a neonate with extensive disease, counterintuitive hypocalcemia, and a family history of SFNN and reviews the existing literature on SFNN.

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Subcutaneous fat necrosis in an infant with hypoxic ischaemic encephalopathy stage 3: an uncommon association

BMJ Case Reports ◽

10.1136/bcr-2020-237933 ◽

2021 ◽

Vol 14 (7) ◽

pp. e237933

Author(s):

Sonalika Mehta ◽

Naveen Parkash Gupta ◽

Anil Batra ◽

Rashmi Sharma

Keyword(s):

Perinatal Asphyxia ◽

Subcutaneous Fat ◽

Birth Asphyxia ◽

Oral Prednisolone ◽

Fat Necrosis ◽

Subcutaneous Fat Necrosis ◽

Dihydroxyvitamin D ◽

History Of ◽

Low Levels ◽

25 Oh Vitamin D

Subcutaneous fat necrosis (SCFN) is inflammation and necrosis of adipose tissue associated with hypoxia and hypothermia. It leads to various metabolic abnormalities, of which the most dreaded is hypercalcaemia. We report a case of a 7-week-old boy with history of birth asphyxia (hypoxic ischaemic encephalopathy stage 3) who presented to us with features suggestive of hypercalcaemia with bilateral nephrocalcinosis. On examination, there were multiple subcutaneous nodules on both arms. Evaluation revealed suppressed parathyroid activity along with low levels of 25(OH)vitamin D3 and elevated 1,25-dihydroxyvitamin D3. Skin biopsy confirmed the diagnosis of SCFN. He was managed with intravenous fluids, single dose of intravenous furosemide and oral prednisolone. Hypercalcaemia responded within 14 days of admission, prednisolone was tapered and stopped in a month. SCFN, in our case, can be attributed to the underlying perinatal asphyxia along with use of therapeutic hypothermia. Through this case, we wish to sensitise practicing neonatologists for the need of screening and early identification of these abnormalities, which if missed can be fatal.

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Subcutaneous fat necrosis of the newborn. A case report

Archives of Dermatology ◽

10.1001/archderm.117.1.36 ◽

1981 ◽

Vol 117 (1) ◽

pp. 36-37 ◽

Cited By ~ 10

Author(s):

T. H. Chen

Keyword(s):

Case Report ◽

Subcutaneous Fat ◽

Fat Necrosis ◽

Subcutaneous Fat Necrosis

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Repeated Occurrence of Skin Necrosis Twice Following Coumarin Intake and Subsequently During Decrease of Vitamin K Dependent Coagulation Factors Associated with Cholestasis

Thrombosis and Haemostasis ◽

10.1055/s-0038-1657270 ◽

1982 ◽

Vol 48 (03) ◽

pp. 245-246 ◽

Cited By ~ 24

Author(s):

V Hofmann ◽

P G Frick

Keyword(s):

Skin Necrosis ◽

Oral Anticoagulants ◽

Subcutaneous Fat ◽

Coagulation Factors ◽

Fat Necrosis ◽

Subcutaneous Fat Necrosis ◽

Skin Changes ◽

Factors Associated ◽

Therapeutic Anticoagulation ◽

Coumarin Necrosis

SummaryA female patient is described who developed skin and subcutaneous fat necrosis on two occasions after intake of acenocoumarol.Several months later identical skin changes occurred during an episode of cholestasis associated with a prolongation of the prothrombin time to an extent comparable with therapeutic anticoagulation; intake of oral anticoagulants could be excluded.This association gives new insights in the pathogenetic mechanisms responsible for the so-called coumarin necrosis and indicates that it may be not due to drug toxicity or allergy.

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