Follicular thyroid cancer avid on C-11 Methionine PET/CT

Summary A case of follicular thyroid cancer with intense focal Methionine uptake on 11C-Methionine PET/CT is reported here. The use of 11C-Methionine PET in differentiated thyroid cancer is currently being investigated as a surrogate tracer compared to the more widely used 18F-FDG PET. This case illustrates the potential incremental value of this modality, not only in the localizing of parathyroid adenoma, but also indicating that 11C-Methionine PET might have a potential of increasing the pretest likelihood of thyroid malignancy in a cold nodule with highly increased Sestamibi uptake. Learning points: 11C-Methionine PET/CT and 18F-Fluorocholine PET/CT often visualizes the parathyroid adenoma in case of negative Tc-99m-MIBI SPECT/CT. A cold nodule in Tc-99m Pertechnetat thyroid scintigraphy with a negative Sestamibi scintigraphy has a very low probability of being malignant. However, the pretest likelihood of thyroid cancer in a cold nodule with increased Sestamibi uptake is low. 11C-Methionine PET might have a potential incremental value in increasing the pretest likelihood of thyroid malignancy in a cold nodule with highly increased Sestamibi uptake.

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FDG PET/CT in the Detection of Metastases in a Patient With Tg and 131I WBS Negative Follicular Thyroid Cancer

Clinical Nuclear Medicine ◽

10.1097/rlu.0b013e3182814c4d ◽

2013 ◽

Vol 38 (3) ◽

pp. 226-227 ◽

Cited By ~ 3

Author(s):

Anar Aliyev ◽

Sabire Ylmaz ◽

Meftune Ozhan ◽

Sertac Asa ◽

Metin Halac

Keyword(s):

Thyroid Cancer ◽

Fdg Pet ◽

Follicular Thyroid Cancer ◽

Pet Ct ◽

Fdg Pet Ct

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Follicular thyroid carcinoma

Acta chirurgica iugoslavica ◽

10.2298/aci0303107k ◽

2003 ◽

Vol 50 (3) ◽

pp. 107-111

Author(s):

Ksenija Krgovic ◽

Ivan Paunovic ◽

Aleksandar Diklic ◽

Vladan Zivaljevic ◽

Svetislav Tatic ◽

...

Keyword(s):

Thyroid Cancer ◽

Surgical Treatment ◽

Adjuvant Therapy ◽

Follicular Thyroid Carcinoma ◽

Cytological Diagnosis ◽

Papillary Thyroid ◽

Thyroid Malignancy ◽

Follicular Thyroid Cancer ◽

Advanced Phase ◽

Risk Of Relapse

Follicular thyroid cancer is the second most common thyroid malignancy. This tumor has a predisposition for hematogenous dissemination an extrathyroid spread. Accurate cytological diagnosis of follicular thyroid cancer is not possible and this fact highlights the necessity for surgical treatment of any suspicious thyroid nodule. Aggressiveness of this tumor is greater than in the case of papillary thyroid cancer and it is the reason for radical surgical treatment of follicular thyroid cancer. Total thyroidectomy facilitates later adjuvant therapy with thyroid hormones and radioiodine. This procedure improves the outcome and the risk of relapse. Results of our study clearly demonstrate that diagnosis of follicular thyroid cancer in us is established in the early phase of the disease (78.57%), but the significant number of the patients (21.43%) is still in the advanced phase of the disease.

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VAIKŲ SKYDLIAUKĖS VĖŽYS PO PERSIRGTOS ONKOLOGINĖS LIGOS

Medicinos teorija ir praktika ◽

10.15591/mtp.2015.016 ◽

2015 ◽

Vol 21 (2.1) ◽

pp. 110-116

Author(s):

Ingrida Albužytė ◽

Gražina Lingė ◽

Gražina Mickunaitienė ◽

Gražina Kleinotienė ◽

Jelena Rascon

Keyword(s):

Thyroid Cancer ◽

Thyroid Gland ◽

Old Age ◽

Age Group ◽

Papillary Thyroid ◽

Thyroid Malignancy ◽

Follicular Thyroid Cancer ◽

Carcinogenic Effect ◽

Pediatric Malignancy

Thyroid cancer is a rare disease in children. Approximately 5 to 6 children in Lithuania are diagnosed thyroid malignancy each year. According to Thyroid Cancer Survivors‘ Association papillary and follicular thyroid cancer accounts approximately for only 1 percent of all paediatric cancers in the 5–9 year old age group and up to 7 percent of cancers in 15–19 year old age group. Thyroid gland in children is more sensitive to the carcinogenic effect of ionizing radiation than in adults. Damage to the thyroid gland after the first paediatric malignancy is usually the result of radiation to the head or neck area. Regular follow-up after the first oncological disease is essential to identify thyroid lesions early so that the proper treatment can be initiated. Fortunately, the prognosis is excellent for the most cases of paediatric thyroid cancer, even if there is metastatic disease at diagnosis. In this article we aimed to review pathogenesis, risk factors and prognosis of the second thyroid cancer following cure for the first pediatric malignancy. We report also a clinical case of papillary thyroid carcinoma diagnosed in a young patient following 13 years after being treated for nephroblastoma.

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Follicular Thyroid Carcinoma in a Country of Endemic Iodine Deficiency (1994–2013)

Journal of Thyroid Research ◽

10.1155/2018/6516035 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5

Author(s):

Edmund Muonir Der

Keyword(s):

Thyroid Cancer ◽

Iodine Deficiency ◽

Neck Swelling ◽

Thyroid Malignancy ◽

Follicular Thyroid Cancer ◽

Anterior Neck ◽

Female Ratio ◽

Gradual Rise ◽

Male Female Ratio ◽

Distant Spread

Background. Follicular thyroid cancer (FTC) has historically been linked to iodine deficiency. Although Ghana is among the iodine deficient regions of the world, the proportions, trends, and the clinical features of FTCs have not been studied as a single disease entity. The aim of this study was to determine the relative frequencies, trends, and the clinicopathological characteristics of FTCs among all thyroid malignancies in our institution.Materials and Methods. This was a retrospective study from January 1994 to December 2013. Data were analysed using SPSS software version 23 (Chicago) and Graph pad prism version 5.00.Results. Follicular thyroid cancer was the second thyroid malignancy (35.0%) and showed a gradual rise in relative proportions over the period. The male-female ratio was 1 : 1.5. The mean ages were 46.9 (SD ±17.3) for males and 46.4 (SD ±13.3) years for females. Enlarged palpable anterior neck swelling was the commonest symptom in males (86.7%) and females (91.3%) (P=0.730). Hurthle cell carcinoma was the commonest variant of FTC, with 26.7% males and 10.6% females (P=0.116). Distant spread was found in 23.3% of males compared to 19.1% of females (P=0.633). The common sites of distant spread were bones (57.2%) in males and cervical lymph nodes (44.4%) in females (P=0.106).Conclusion. Follicular thyroid cancer was the second common thyroid malignancy (35.0%) with a gradual rise in trend over the study period and male-female ratio of 1.5 : 1. Large anterior neck swelling was the commonest clinical presentation of FTC.

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