scholarly journals The effects of Syzygium aromaticum-derived oleanolic acid on reactive oxygen species in the heart, liver and kidney of STZ-induced diabetic rats

2013 ◽  
pp. 1-1
Author(s):  
Blessing Mkhwanazi ◽  
Ntethelelo Sibiya ◽  
Metse Serumala ◽  
Rene Myburg ◽  
Cephas T Musabayane
2012 ◽  
Vol 50 (3) ◽  
pp. 177-183 ◽  
Author(s):  
Joamyr Victor Rossoni-Júnior ◽  
Glaucy Rodrigues Araújo ◽  
Bruno da Cruz Pádua ◽  
Míriam Martins Chaves ◽  
Maria Lúcia Pedrosa ◽  
...  

2011 ◽  
Vol 45 (10) ◽  
pp. 1143-1153 ◽  
Author(s):  
Daniel E. Francés ◽  
María T. Ronco ◽  
Paola I. Ingaramo ◽  
Juan A. Monti ◽  
Gerardo B. Pisani ◽  
...  

2020 ◽  
Vol 25 (2) ◽  
pp. 76
Author(s):  
Eka Pratama Putri ◽  
Sri Rahayu Lestari ◽  
Abdul Gofur

Hyperglycemia conditions increase free radicals in the body that cause oxidative stress. Oxidative stress increase lipid peroxidation activity and reactive oxygen species (ROS). An antioxidant can prevent a free radical movement. The materials that contain potent antioxidants are black soybeans tempeh (BST) and purple sweet potatoes (PSP). The antioxidants in the BST are isoflavones with their derivates, and PSP is anthocyanins. This study aimed to determine the effect of BST and PSP extract on reactive oxygen species (ROS) and malondialdehyde (MDA) levels. In this study, rats were given a high-fat diet, 10% sucrose drink, and injected with multiple low-dose streptozotocin to induce T2DM. The animal's experiment divided into six groups: healthy rats, DM rats, DM rats + glibenclamide, DM rats + combination of BST and PSP in 3:1, 1:1, and 1:3 respectively. ROS levels were determined using the ELISA method and MDA levels were determined using spectrophotometer according to Thiobarbituric Acid (TBA) method. Our result suggests that the combination of BST and PSP significantly reduces ROS and MDA levels.


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