The relationship of vibration perception threshold with metabolic control and duration of disease in British children with type 1 diabetes

Objective: As diabetes technology use in youth increases worldwide, inequalities in access may exacerbate disparities in hemoglobin A1c (HbA1c). We hypothesized an increasing gap in diabetes technology use by socioeconomic status (SES) would be associated with increased HbA1c disparities. Research Design and Methods: Participants aged <18 years with diabetes duration ≥1 year in the Type 1 Diabetes Exchange (T1DX, US, n=16,457) and Diabetes Prospective Follow-up (DPV, Germany, n=39,836) registries were categorized into lowest (Q1) to highest (Q5) SES quintiles. Multiple regression analyses compared the relationship of SES quintiles with diabetes technology use and HbA1c from 2010-2012 and 2016-2018. Results: HbA1c was higher in participants with lower SES (in 2010-2012 & 2016-2018, respectively: 8.0% & 7.8% in Q1 and 7.6% & 7.5% in Q5 for DPV; and 9.0% & 9.3% in Q1 and 7.8% & 8.0% in Q5 for T1DX). For DPV, the association between SES and HbA1c did not change between the two time periods, whereas for T1DX, disparities in HbA1c by SES increased significantly (p<0.001). After adjusting for technology use, results for DPV did not change whereas the increase in T1DX was no longer significant. Conclusions: Although causal conclusions cannot be drawn, diabetes technology use is lowest and HbA1c is highest in those of the lowest SES quintile in the T1DX and this difference for HbA1c broadened in the last decade. Associations of SES with technology use and HbA1c were weaker in the DPV registry.

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PREDICTION OF OCCURRENCE AND THE RELATIONSHIP OF AUTOIMMUNE DISEASES IN CHILDREN WITH TYPE 1 DIABETES

European Science Review ◽

10.29013/esr-19-5.6-41-43 ◽

2019 ◽

pp. 41-43

Author(s):

A. A. Sadirkhodjaeva ◽

D. T. Ashurova

Keyword(s):

Type 1 Diabetes ◽

Autoimmune Diseases ◽

Relationship Of ◽

The Relationship

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The relationship between diabetes self-management and metabolic control in youth with type 1 diabetes: an integrative review

Journal of Advanced Nursing ◽

10.1111/j.1365-2648.2011.05697.x ◽

2011 ◽

Vol 67 (11) ◽

pp. 2294-2310 ◽

Cited By ~ 38

Author(s):

Jia Guo ◽

Robin Whittemore ◽

Guo-Ping He

Keyword(s):

Type 1 Diabetes ◽

Metabolic Control ◽

Integrative Review ◽

Self Management ◽

The Relationship

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Relationship Between Glycated Hemoglobin and Vibration Perception Threshold in Diabetic Peripheral Neuropathy

The International Journal of Lower Extremity Wounds ◽

10.1177/1534734619882173 ◽

2019 ◽

Vol 19 (2) ◽

pp. 120-124 ◽

Cited By ~ 2

Author(s):

Arun G. Maiya ◽

Anche Parameshwar ◽

Manjunath Hande ◽

Vinayak Nandalike

Keyword(s):

Peripheral Neuropathy ◽

Diabetic Peripheral Neuropathy ◽

Glycated Hemoglobin ◽

Pearson Correlation ◽

Regression Result ◽

Perception Threshold ◽

Cross Sectional ◽

Vibration Perception Threshold ◽

The Relationship ◽

Vibration Perception

Foot ulcers, infections, and deformity are some of the major sources of mortality and morbidity among the diabetic population. The relationship between glycated hemoglobin (HbA1c) and diabetic peripheral neuropathy (DPN) has been well established. There is a dearth of literature on the relationship between vibration perception threshold (VPT) and HbA1c values. So, the objective of the study was to determine the strength of linear relationship between HbA1c levels and vibration perception threshold in DPN. This cross-sectional study was conducted at Kasturba Hospital, Manipal, and diabetic foot screening camps held at various parts of Udupi district. Ethical approval was obtained from the Institutional Ethics Committee, Kasturba Hospital, Manipal (IEC:281/2017). A total of 534 participants ranging from 30 to 70 years of age and were diagnosed with type 2 diabetes mellitus on medications were included in the study. Neuropathy assessment consisting of monofilament and vibration perception threshold was done using Neurotouch beta version (Yostra Labs, Bengaluru, India). HbA1c measurement was done using turbidimetric inhibition immunoassay technique (Roche Diagnostics, Mannheim, Germany). Pearson correlation coefficient showed a moderate to good correlation between HbA1c and VPT ( r = .0.753, P < .001). Linear regression result has shown a significant relationship of VPT with HbA1c (4.033 [95% confidence interval = 3.67-4.39]). The present study has concluded that there is strong relationship between HbA1c values and VPT and could be a predictor for complications in the foot following DPN.

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Sex difference in the relationship of calcium and magnesium excretion to glycaemic control in type 1 diabetes mellitus

Clinica Chimica Acta ◽

10.1016/s0009-8981(99)00040-6 ◽

1999 ◽

Vol 283 (1-2) ◽

pp. 119-128 ◽

Cited By ~ 23

Author(s):

Iain R. Brown ◽

Alasdair M. McBain ◽

John Chalmers ◽

Ian W. Campbell ◽

Ewan R. Brown ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Glycaemic Control ◽

Type 1 Diabetes Mellitus ◽

Sex Difference ◽

Calcium And Magnesium ◽

Magnesium Excretion ◽

Relationship Of ◽

The Relationship

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Depression and the Reporting of Diabetes Symptoms

The International Journal of Psychiatry in Medicine ◽

10.2190/lw52-jfkm-jchv-j67x ◽

1989 ◽

Vol 18 (4) ◽

pp. 295-303 ◽

Cited By ~ 64

Author(s):

Patrick J. Lustman ◽

Ray E. Clouse ◽

Robert M. Carney

Keyword(s):

Metabolic Control ◽

Glycosylated Hemoglobin ◽

Blood Glucose Control ◽

Depressive Mood ◽

Diabetes Mellitus Type 1 ◽

Patients With Diabetes ◽

Relationship Of ◽

The Relationship

The relationship of diabetes symptoms to current mood and general metabolic control was studied. Symptoms commonly associated with poorly controlled diabetes (e.g., thirst, polyuria, weight loss) were measured in 114 patients with diabetes mellitus (type 1 = 57, type 2 = 57). Scores for these individual symptoms were correlated with glycosylated hemoglobin (HbA1) and depression as measured by the Beck Depression Inventory (BDI). HbA1 was poorly correlated ( r < 0.2) with nine of the eleven symptoms and made a significant independent contribution only to the reporting of polyuria ( p = 0.04). In contrast, depression was moderately correlated with nine symptoms and had a significant effect on the reporting of two of three hyperglycemic symptoms, five of six hypoglycemic symptoms, and both nonspecific symptoms of poor control ( p < 0.05 for each). We conclude that many reported symptoms often attributed to diabetes are more related to depressive mood than to a conventional clinical measure of blood glucose control. Diabetes symptoms may be unreliable indicators of poor metabolic control when features suggestive of depression are present.

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