Maternal distress associates with placental genes regulating foetal glucocorticoid exposure and IGF2: role of obesity and sex

This paper reviews the effects of maternal distress on several aspects of parent—child interactions that were identified in the course of a parent training program for child non-compliance. Distress was measured by a number of self-report questionnaires examining depression, anxiety, marital relations, and extrafamilial relationships. The parent training program is initially reviewed. Subsequently, pretreatment relationships between maternal distress and parent—child interactions were examined. Distress appears to be related primarily to measures of parent perceptions of child maladjustment. Several relationships between distress and treatment outcome also were noted. A recent study designed to enhance parent training by modifying maternal distress factors is presented. Finally, implications and limitations of the data are discussed.

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The Role of Maternal Stress and Family Functioning in Maternal Distress and Mother-Reported and Child-Reported Psychological Adjustment of Nonreferred Children

Journal of Clinical Child Psychology ◽

10.1207/s15374424jccp2201_8 ◽

1993 ◽

Vol 22 (1) ◽

pp. 78-84 ◽

Cited By ~ 15

Author(s):

Robert J. Thompson Jr. ◽

Kathy A. Merritt ◽

Barbara R. Keith ◽

Laura Bennett Murphy ◽

David A. Johndrow

Keyword(s):

Family Functioning ◽

Psychological Adjustment ◽

Maternal Stress ◽

Maternal Distress

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Socioeconomic disadvantages and neural sensitivity to infant cry: role of maternal distress

Social Cognitive and Affective Neuroscience ◽

10.1093/scan/nsw063 ◽

2016 ◽

Vol 11 (10) ◽

pp. 1597-1607 ◽

Cited By ~ 25

Author(s):

Pilyoung Kim ◽

Christian Capistrano ◽

Christina Congleton

Keyword(s):

Maternal Distress ◽

Infant Cry

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Street drug use during pregnancy: potential programming effects on preschool wheeze

Journal of Developmental Origins of Health and Disease ◽

10.1017/s2040174412000670 ◽

2012 ◽

Vol 4 (2) ◽

pp. 191-199 ◽

Cited By ~ 3

Author(s):

M. E. Alton ◽

S. C. Tough ◽

P. J. Mandhane ◽

A. L. Kozyrskyj

Keyword(s):

Alcohol Use ◽

Drug Use ◽

Perinatal Care ◽

Maternal Distress ◽

Substance Abusing ◽

Prenatal Programming ◽

Questionnaire Data ◽

Independent Association ◽

The Impact

Street drug use during pregnancy is detrimental to fetal development. Although the prevalence of wheeze is high in offspring of substance-abusing mothers, nothing is known about the role of street drug use during pregnancy in its development. We investigated the impact of maternal street drug use and distress during pregnancy on the development of wheeze and allergy in preschool children. Questionnaire data were accessed from the Community Perinatal Care trial of 791 mother–child pairs in Calgary, Alberta. Using logistic regression, the association between maternal substance use and distress during pregnancy, and wheeze and allergy at age 3 years was determined in boys and girls. After adjusting for alcohol use during pregnancy, pre- and postnatal tobacco use, preterm birth, duration of exclusive breastfeeding, daycare attendance and maternal socioeconomic status, maternal street drug use during pregnancy [odds ratio (OR): 5.02, 95% confidence interval (CI): 1.30–19.4] and severe maternal distress during pregnancy (OR: 5.79, 95% CI: 1.25–26.8) were associated with wheeze in girls. In boys, an independent association was found between severe distress during pregnancy (OR: 3.85, 95% CI: 1.11–13.3) and allergies, but there was no association with maternal street drug use. In conclusion, we found an association between maternal street drug use and wheeze in preschool girls that could not be accounted for by maternal distress, smoking or alcohol use during pregnancy. Prenatal programming effects of street drugs may explain this association.

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The Brabant study: design of a large prospective perinatal cohort study among pregnant women investigating obstetric outcome from a biopsychosocial perspective

BMJ Open ◽

10.1136/bmjopen-2020-038891 ◽

2020 ◽

Vol 10 (10) ◽

pp. e038891

Author(s):

Margreet Meems ◽

Lianne Hulsbosch ◽

Madelon Riem ◽

Christina Meyers ◽

Tila Pronk ◽

...

Keyword(s):

Cohort Study ◽

Pregnant Women ◽

Thyroid Function ◽

Maternal Distress ◽

Obstetric Outcomes ◽

Social Changes ◽

Obstetric Outcome ◽

Partner Relationship ◽

Pregnancy Distress

BackgroundPregnancy is characterised by many biological and psychosocial changes. Adequate maternal thyroid function is important for the developing fetus throughout gestation. Latent class analyses recently showed three different patterns of change in thyroid function throughout pregnancy with different associations with obstetric outcome. Maternal distress during the pregnancy (anxiety and depression) negatively affects obstetric outcome. Pregnancy distress in turn may be affected by personality traits and attachment styles. Moreover, during the pregnancy, substantial social changes occur in the partner relationship and work experience. The aim of the Brabant study is to investigate the association between thyroid function trajectories and obstetric outcomes. Moreover, within the Brabant study, we will investigate how different trajectories of pregnancy distress are related to obstetric outcome, and the role of personality in this association. We will evaluate the possible role of maternal distress and attachment style on maternal–fetal bonding. Finally, we will study social changes in the perinatal period regarding partner relationship and well-being and performance at work.Methods and analysisThe Brabant study is a longitudinal, prospective cohort study of an anticipated 4000 pregnant women. Women will be recruited at 8–10 weeks gestation among community midwife practices in South-East Brabant in the Netherlands. Thyroid function parameters (TSH and fT4), thyroid peroxidase antibody and human chorionic gonadotrophin will be assessed at 12, 20 and 28 weeks gestation. Moreover, at these three time points women will fill out questionnaires assessing demographic and obstetric features, life style habits and psychological and social variables, such as depressive symptoms, personality, partner relationship quality and burnout. Data from the obstetric records will also be collected.Ethics and disseminationThe study has been approved by the Medical Ethical Committee of the Máxima Medical Center Veldhoven. Results will be submitted to peer-reviewed journals in the relevant fields and presented on national and international conferences.

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