Significant difference between the prevalence of C cell hyperplasia (CCH) in benign thyroid nodules without histological thyroiditis (HT) and in papillary/follicular thyroid cancers (PTC/FTC) at histology

Author(s):  
Letizia Pieruzzi ◽  
Eleonora Molinaro ◽  
Laura Agate ◽  
Valeria Bottici ◽  
Liborio Torregrossa ◽  
...  
QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Khaled Fikry Tawfik Shehab ◽  
Ahmed Mohamed Hussein ◽  
Rasha Tolba Khattab

Abstract Purpose This study evaluates the outcome of patients complaining of compressive& cosmetic problems due to benign thyroid nodules after recieving RF ablation with correlation between some ultrasound features of the nodules and their shrinkage and volume reduction. Methods and material fifteen patients with benign thyroid nodules causing compressive symptoms (foreign body sensation,neck discomfort or pain) and cosmetic problems. Results A total of 15 patients were included with the age rangmg from 22-82 years old the mean was 52.73 years old (SD + 14.37).Among them 12 patients (800 0)were females and 3 patients(20%) were males. There was statistically significant difference between volume of nodules before the procedure with mean volume was 21.13±5.13 and I month after with mean volume I I .96±3.08 and 3 months after the procedure with mean volume 7.70±2.82 with noticeable improvement in nodules with peri and intranodular vascularity showing mean reduction ratio 69.88% after 3 months vs 59.93% and 64 12% of weak peripheral vascularity and intense intra-nodular vasculanty respectively as well as US structure with spongiform nodules showing mean reduction ratio 68.48% at 3 months vs 59.87% and 62.14% for solid &mixed nodules respectively.Mean symptoms and cosmetic score were significantly reduced. Conclusion: This study validated the efficacy and safety of RFA for treatment of benign thyroid nodules and showed correlation between shrinkage and some common US findings.


2012 ◽  
Vol 13 (2) ◽  
pp. 117 ◽  
Author(s):  
Dong Gyu Na ◽  
Jeong Hyun Lee ◽  
So Lyung Jung ◽  
Ji-hoon Kim ◽  
Jin Yong Sung ◽  
...  

2016 ◽  
Vol 27 (8) ◽  
pp. 3128-3137 ◽  
Author(s):  
Cherry Kim ◽  
Jeong Hyun Lee ◽  
Young Jun Choi ◽  
Won Bae Kim ◽  
Tae Yon Sung ◽  
...  

2014 ◽  
Vol 119 (7) ◽  
pp. 512-520 ◽  
Author(s):  
Irene Chiara De Bernardi ◽  
Chiara Floridi ◽  
Alessandra Muollo ◽  
Roberta Giacchero ◽  
Gian Lorenzo Dionigi ◽  
...  

2020 ◽  
Author(s):  
Jianhua Li ◽  
Wenping Xue ◽  
Pengfei Xu ◽  
Zhen Deng ◽  
Caiwen Duan ◽  
...  

Abstract Percutaneous radiofrequency ablation (RFA) has been recommended as minimally invasive treatment for patients with symptomatic benign thyroid nodules (BTNs) because of the large number of clinical applications. This retrospective observational study sought to evaluate the clinical outcomes of RFA for BTNs. From 2014 to 2019, a sample size of 1289 patients treated by RFA were 226 ones with solid nodules and 865 ones with cystic-solid nodule, respectively. The efficacy including the nodule maximal diameter reduction ratio (MDRR), the volume reduction ratio (VRR) and the cosmetic scores reduction ratio (CSRR). The results of the nodule MDRR and VRR in the cystic-solid nodule group were significantly better than those in the solid nodule group at the 3rd and 6th month, and the CSRR in the two groups showed statistically significant difference at the 3rd month. In a word, RFA is an effective method for symptomatic benign solid or cystic-solid nodules. The achieved MDRR and VRR in the cystic-solid nodule group were significantly better than those in the solid nodule group at the 3rd and 6th month.


2019 ◽  
Vol 9 (7) ◽  
pp. 1494 ◽  
Author(s):  
Yu Yan ◽  
Wei Zhu ◽  
Yi-yun Wu ◽  
Dong Zhang

Recently, there is increasing interest in identifying benign and malignant nodules by using ultrasound diagnostic technology, which should be helpful to release patients with benign thyroid nodules from suffering unnecessary needle biopsy. In this work, fractal analysis was investigated for the capability of differentiating benign from malignant thyroid nodules during ultrasonography. The B-mode images for 57 patients with suspicious thyroid nodules were captured, followed by ultrasound-guided needle aspiration. The region of interests (ROIs) were subsequently selected from ultrasound images. Then, fractal analysis was performed to extract fractal texture features, and derive the fractal dimension of ROI. The results showed that a significant difference was observed between benign and malignant thyroid nodules (p < 0.05), by comparing this parameter based on independent nonparametric Mann‒Whitney U test. It suggested that fractal dimension is a helpful feature for distinguishing thyroid nodules. In addition, fractal analysis of the B-mode image can provide a reliable reference for tissue typing in ultrasound diagnosis.


2022 ◽  
Vol 12 (1) ◽  
pp. 63
Author(s):  
Wei-Che Lin ◽  
Cheng-Kang Wang ◽  
Wen-Hung Wang ◽  
Chi-Yu Kuo ◽  
Pi-Ling Chiang ◽  
...  

Background: To evaluate the effectiveness and safety of radiofrequency ablation (RFA) treatment for benign thyroid nodules (BTNs) in five medical centers in Taiwan. Methods: From April 2016 to July 2020, 762 patients underwent ultrasound guided RFA treatment of 826 benign thyroid nodules at five medical centers in Taiwan. The RFA procedure was performed by radiologists, otolaryngologists, or surgeons. Patients were grouped into three subgroups according to the initial volume of BTNs. The volume reduction ratio (VRR) of each nodule, and complications were analyzed at 1, 3, and 6 months after RFA treatment and the three groups compared. Results: The large nodular group showed greater VRR compared to the other two groups at first 1-month follow-up. At 6-months follow-up, there was no significant difference of VRR among the three groups. Goiters with difference in size can attain a successful VRR (>50%) although different specialists demonstrated variable VRR after 6-months follow-up. A total of 40 (4.8%) complications were reported. All patients recovered spontaneously without surgery intervention. Conclusions: The reliability and safety of RFA for benign thyroid nodules had been established. RFA has gradually become an alternative to surgery in the treatment of benign thyroid nodules in Taiwan.


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