Ultrasound predictive criteria for short term benign thyroid nodular volume reduction after ultrasound guided radiofrequency ablation

Abstract Purpose This study evaluates the outcome of patients complaining of compressive& cosmetic problems due to benign thyroid nodules after recieving RF ablation with correlation between some ultrasound features of the nodules and their shrinkage and volume reduction. Methods and material fifteen patients with benign thyroid nodules causing compressive symptoms (foreign body sensation,neck discomfort or pain) and cosmetic problems. Results A total of 15 patients were included with the age rangmg from 22-82 years old the mean was 52.73 years old (SD + 14.37).Among them 12 patients (800 0)were females and 3 patients(20%) were males. There was statistically significant difference between volume of nodules before the procedure with mean volume was 21.13±5.13 and I month after with mean volume I I .96±3.08 and 3 months after the procedure with mean volume 7.70±2.82 with noticeable improvement in nodules with peri and intranodular vascularity showing mean reduction ratio 69.88% after 3 months vs 59.93% and 64 12% of weak peripheral vascularity and intense intra-nodular vasculanty respectively as well as US structure with spongiform nodules showing mean reduction ratio 68.48% at 3 months vs 59.87% and 62.14% for solid &mixed nodules respectively.Mean symptoms and cosmetic score were significantly reduced. Conclusion: This study validated the efficacy and safety of RFA for treatment of benign thyroid nodules and showed correlation between shrinkage and some common US findings.

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Ultrasound-Guided Microwave Ablation for Benign Thyroid Nodules: A Retrospective Analysis of Safety and Efficacy Factors

10.21203/rs.3.rs-137725/v1 ◽

2021 ◽

Author(s):

Baoying Xia ◽

Boyang Yu ◽

Xiaofei Wang ◽

Yu Ma ◽

Feng Liu ◽

...

Keyword(s):

Microwave Ablation ◽

Thyroid Nodules ◽

Thyroid Volume ◽

Serum Levels ◽

Reduction Ratio ◽

Volume Reduction ◽

Invasive Technique ◽

Ultrasound Guided ◽

Benign Thyroid Nodules ◽

Benign Thyroid

Abstract ObjectiveMicrowave ablation (MWA) is a minimally invasive technique for the treatment of benign thyroid nodules. The purpose of this study was to evaluate the efficacy and safety of ultrasound-guided microwave ablation in the treatment of benign thyroid nodules, and to provide reference for future clinical work.MethodsThis study retrospectively analyzed the patients who received ultrasound-guided microwave ablation for benign thyroid nodules in our hospital from October 2018 to March 2020. A total of 214 patients were included in the study. We assessed thyroid volume changes (represented by volume reduction ratio VRR) , the serum levels of triiodide thyroid hormone (T3), thyroxine (T4) and thyrotropin (TSH) and complications after MWA treatment.ResultsThere were a total of 306 nodules in 214 patients, including 183 (85.51%) females and 31 (14.49%) males. The median diameter and volume of the nodule were 33mm and 8.01ml. The volume reduction ratio（VRR）at 1 month, 3 months, 6 months and 12 months were 40.79%, 60.37%, 74.59% and 85.60%, respectively.（P<0.05) In addition, initial nodular volume were the influencing factors of volume reduction ratio.ConclusionsUltrasound-guided MWA is effective and safe in the treatment of benign thyroid nodules. In addition, it has little damage to surrounding tissues and no effect on thyroid function. Especially for the initial small volume of nodules, treatment is better. Therefore, ultrasound-guided thyroid MWA can be used as one of the main clinical treatment methods for benign thyroid nodules.

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Efficacy and Safety of Single-Session Radiofrequency Ablation in Treating Benign Thyroid Nodules: A Short-Term Prospective Cohort Study

10.21203/rs.3.rs-776049/v1 ◽

2021 ◽

Author(s):

Bang Nguyen Van ◽

Xuan Thi Nguyen ◽

Hau Van Vy Nguyen ◽

Thuy Hai Nguyen ◽

Toan Dinh Nguyen ◽

...

Keyword(s):

Success Rate ◽

Thyroid Nodules ◽

Reduction Ratio ◽

Volume Reduction ◽

Thyroid Function Tests ◽

Short Term ◽

Therapeutic Success ◽

Benign Thyroid Nodules ◽

Benign Thyroid

Abstract Objective:The aims of this study are to evaluate the safety and efficacy of RFA in the treatment of benign thyroid nodule(s) and to find independent factors related to the volume reduction rate of the nodule(s).Materials and methods: This short-term prospective study from a single medical center was conducted on 93 benign thyroid nodules in 93 patients treated with RFA. Two basic techniques were used: the trans-isthmic approach, moving-shot technique. Clinical and ultrasonography examinations were performed at 1; 3 months follow-up after the treatment session. Primary outcomes included volume reduction ratio (VRR) at 1 month and 3 months follow-ups; Secondary outcomes were therapeutic success rate and complications. Multiple linear regression analysis was used to determine independent factors associated with VRR. Results: A final sample of 78 patients with 78 nodules, given participant rate 83.8%, (included 60 solid nodules, 16 predominantly cystic nodules, and 2 thyroid cysts) was followed for 3 months. The mean volume reduction ratio was 41.47% and 64.72% after 1 month and 3 months follow-ups, respectively. The therapeutic success rate was 30.8% at 1 month and 84.6% at 3-month follow-ups. Symptom score and cosmetic score improved significantly. There was no change in thyroid function tests. Two minor complications (transient voice change) were found. The only internal component of nodules significantly related to the VRR during the 3 months follow-up (b = 23.00; 95%CI (7.59 - 38.45)).Conclusion: RFA was demonstrated as a safe and effective option for benign thyroid nodules treatment. It can be used as an alternative treatment with encouraging results.

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Radiofrequency Ablation for Benign Thyroid Nodules: Efficacy According to the Types of Thyroid Nodules

10.21203/rs.3.rs-107864/v1 ◽

2020 ◽

Author(s):

Jianhua Li ◽

Wenping Xue ◽

Pengfei Xu ◽

Zhen Deng ◽

Caiwen Duan ◽

...

Keyword(s):

Radiofrequency Ablation ◽

Thyroid Nodules ◽

Reduction Ratio ◽

Invasive Treatment ◽

Solid Nodule ◽

Maximal Diameter ◽

Significant Difference ◽

Benign Thyroid Nodules ◽

Benign Thyroid ◽

Better Than

Abstract Percutaneous radiofrequency ablation (RFA) has been recommended as minimally invasive treatment for patients with symptomatic benign thyroid nodules (BTNs) because of the large number of clinical applications. This retrospective observational study sought to evaluate the clinical outcomes of RFA for BTNs. From 2014 to 2019, a sample size of 1289 patients treated by RFA were 226 ones with solid nodules and 865 ones with cystic-solid nodule, respectively. The efficacy including the nodule maximal diameter reduction ratio (MDRR), the volume reduction ratio (VRR) and the cosmetic scores reduction ratio (CSRR). The results of the nodule MDRR and VRR in the cystic-solid nodule group were significantly better than those in the solid nodule group at the 3rd and 6th month, and the CSRR in the two groups showed statistically significant difference at the 3rd month. In a word, RFA is an effective method for symptomatic benign solid or cystic-solid nodules. The achieved MDRR and VRR in the cystic-solid nodule group were significantly better than those in the solid nodule group at the 3rd and 6th month.

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Efficacy on radiofrequency ablation according to the types of benign thyroid nodules

Scientific Reports ◽

10.1038/s41598-021-01593-9 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Jianhua Li ◽

Wenping Xue ◽

Pengfei Xu ◽

Zhen Deng ◽

Caiwen Duan ◽

...

Keyword(s):

Radiofrequency Ablation ◽

Thyroid Nodules ◽

Reduction Ratio ◽

Invasive Treatment ◽

Solid Nodule ◽

Maximal Diameter ◽

Significant Difference ◽

Benign Thyroid Nodules ◽

Benign Thyroid ◽

Better Than

AbstractPercutaneous radiofrequency ablation (RFA) has been recommended as minimally invasive treatment for patients with symptomatic benign thyroid nodules (BTNs) because of the large number of clinical applications. This retrospective observational study sought to evaluate the clinical outcomes of RFA for BTNs. From 2014 to 2019, a sample size of 1289 patients treated by RFA were 262 ones with solid nodules and 1027 ones with cystic-solid nodule, respectively. The efficacy including the nodule maximal diameter reduction ratio (MDRR), the volume reduction ratio (VRR) and the cosmetic scores reduction ratio (CSRR). The results of the nodule MDRR and VRR in the cystic-solid nodule group were significantly better than those in the solid nodule group at the 3rd and 6th month, and the CSRR in the two groups showed statistically significant difference at the 3rd month. In a word, RFA is an effective method for symptomatic benign solid or cystic-solid nodules. The achieved MDRR and VRR in the cystic-solid nodule group were significantly better than those in the solid nodule group at the 3rd and 6th month.

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Significant difference between the prevalence of C cell hyperplasia (CCH) in benign thyroid nodules without histological thyroiditis (HT) and in papillary/follicular thyroid cancers (PTC/FTC) at histology

Endocrine Abstracts ◽

10.1530/endoabs.49.ep1414 ◽

2017 ◽

Author(s):

Letizia Pieruzzi ◽

Eleonora Molinaro ◽

Laura Agate ◽

Valeria Bottici ◽

Liborio Torregrossa ◽

...

Keyword(s):

Thyroid Nodules ◽

Cell Hyperplasia ◽

Thyroid Cancers ◽

C Cell Hyperplasia ◽

C Cell ◽

Significant Difference ◽

Benign Thyroid Nodules ◽

Benign Thyroid

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Ultrasound-guided microwave ablation in the treatment of benign thyroid nodules in 435 patients

Experimental Biology and Medicine ◽

10.1177/1535370217727477 ◽

2017 ◽

Vol 242 (15) ◽

pp. 1515-1523 ◽

Cited By ~ 21

Author(s):

Yu-Jiang Liu ◽

Lin-Xue Qian ◽

Dong Liu ◽

Jun-Feng Zhao

Keyword(s):

Microwave Ablation ◽

Thyroid Nodules ◽

Reduction Rate ◽

Volume Reduction ◽

Ultrasound Guided ◽

Nodule Volume ◽

Safe Technique ◽

Benign Thyroid Nodules ◽

Benign Thyroid

The objective of the present study was to investigate the effectiveness and safety of ultrasound-guided microwave ablation in the treatment of benign thyroid nodules. A total of 474 benign thyroid nodules in 435 patients who underwent ultrasound-guided microwave ablation from September 2012 to August 2015 were included. Nodule volume and thyroid function were measured before treatment and at 1, 3, 6, and 12 months and subsequently after every 6 months. The nodule volume reduction rate and changes of thyroid function were evaluated. The volume of all thyroid nodules significantly decreased after ultrasound-guided microwave ablation. The average volume was 13.07 ± 0.95 ml before treatment, and 1.14 ± 0.26 ml at 12-months follow-up. The mean volume reduction rate was 90% and the final volume reduction rate was 94%. The volume reduction rate of mainly cystic nodules was significantly higher than that of simple solid and mainly solid nodules (all P < 0.05). The pretreatment volume of nodules was positively correlated with the final volume reduction rate at final follow-up ( P = 0.004). No serious complications were observed after treatment. In conclusion, ultrasound-guided microwave ablation is an effective and safe technique for treatment of benign thyroid nodules, and has the potential for clinical applications. Impact statement Ultrasound-guided MWA is an effective and safe technique for the treatment of benign thyroid nodules. It can significantly reduce the nodule volume, improve the patients’ clinical symptoms, has less complication, guarantees quick recovery, meets patients' aesthetic needs, and shows less interference on the physiological and psychological aspects of the body. MWA should be a good complement to traditional open surgery and has potentials in clinical applications.

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Microwave Ablation of Symptomatic Benign Thyroid Nodules: Energy Requirement per ml Volume Reduction

RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren ◽

10.1055/s-0042-115416 ◽

2016 ◽

Vol 188 (11) ◽

pp. 1054-1060 ◽

Cited By ~ 7

Author(s):

Y. Korkusuz ◽

K. Kohlhase ◽

D. Gröner ◽

C. Erbelding ◽

W. Luboldt ◽

...

Keyword(s):

Microwave Ablation ◽

Thyroid Nodules ◽

Energy Requirement ◽

Volume Reduction ◽

Benign Thyroid Nodules ◽

Benign Thyroid

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Predictor Analysis in Radiofrequency Ablation of Benign Thyroid Nodules: A Single Center Experience

Frontiers in Endocrinology ◽

10.3389/fendo.2021.638880 ◽

2021 ◽

Vol 12 ◽

Author(s):

Alessandro Bisceglia ◽

Ruth Rossetto ◽

Sara Garberoglio ◽

Angelica Franzin ◽

Alice Cerato ◽

...

Keyword(s):

Radiofrequency Ablation ◽

Thyroid Nodules ◽

Neck Circumference ◽

Volume Reduction ◽

Single Center ◽

Treatment Volume ◽

Pre Treatment ◽

Benign Thyroid Nodules ◽

Benign Thyroid

PurposeTo confirm the efficacy of ultrasound (US) guided radiofrequency ablation (RFA) in the treatment of benign thyroid nodules, we evaluated as primary outcome the technical efficacy and clinical success in a single center dataset. The secondary outcome was to find a correlation between nodules’ pre-treatment features and volume reduction rate (VRR) ≥75% at 12 months after RFA and during follow-up period.MethodsThis retrospective study included 119 consecutive patients (99 females, 20 males, 51.5 ± 14.4 years) with benign thyroid nodules treated in our hospital between October 2014 and December 2018 with a mean follow-up of 26.8 months (range 3–48). Clinical and US features before and after RFA were evaluated by a US examination at 1, 3, 6, 12 months and annually thereafter up to 48 months.ResultsThe median pre-treatment volume was 22.4 ml; after RFA we observed a statistically significant volume reduction from the first month (11.7 ml) to the last follow-up (p < 0.001 for all follow-up times). The median VRR was 47.1, 55.3, 61.2, 67.6, 72.8, 71.3, and 62.9% at 1, 3, 6, 12, 24, 36, and 48 months of follow-up respectively, showing a progressive significant improvement up to 24 months (VRRs 1 vs 3 months, 3 vs 6 months and 6 vs 12 months p < 0.001, 12 vs 24 months p = 0.05) while no differences at 24 vs 36 and 36 vs 48 months were observed. Symptoms improved significantly (complete resolution 64.35%, partial resolution 35.65%), and neck circumference was reduced as compared to pre-treatment (p < 0.001). Lower pre-treatment neck circumference (37.5 vs 36.0 cm, p = 0.01) was a positive predictor of VRR ≥75% at 12 months. Macrocystic echostructure (HR 2.48, p 0.046) and pre-treatment volume >22.4 ml (HR 0.54, p 0.036) were found to be independent positive and negative predictors of VRR ≥75% respectively. One-month post RFA VRR ≥50% represented the best positive predictor of technical success.ConclusionsThis study confirmed the efficacy of RFA in the treatment of benign thyroid nodules. In particular we show that by selecting macrocystic nodules smaller than 22.4 ml better long-term response can be achieved, which is predicted by an early shrinkage of the nodule.

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Evaluation of Ethanol Injection, Radiofrequency Ablation, and Levothyroxine Therapy in the Management of Benign Thyroid Nodules

10.21203/rs.3.rs-94756/v1 ◽

2020 ◽

Author(s):

Alireza Arefzadeh ◽

hossein ghanaati ◽

Mahsa Alborzi Avankai ◽

Alireza Abrishami ◽

Hamidreza Niazkar ◽

...

Keyword(s):

Radiofrequency Ablation ◽

Treatment Group ◽

Thyroid Nodules ◽

Volume Reduction ◽

The Other ◽

Single Session ◽

Ethanol Injection ◽

Injection Group ◽

Benign Thyroid Nodules ◽

Benign Thyroid

Abstract Background: Thyroid nodules are a common clinical finding. Even though there are various accepted treatments for the benign thyroid nodules, there are alternative methods for managing these patients with fewer expenses and also minimum complications. This study aims to compare the volume decline of radiofrequency (RF) ablation and single-session ethanol ablation (EA) and the effects of levothyroxine therapy for benign thyroid nodule treatment.Materials: In this clinical trial, 90 patients with benign thyroid nodules in different centers in Tehran, Iran, from December 6, 2018, to December 6, 2019, were included. Patients who had met the inclusion criteria were selected and randomly allocated into three groups (each of 30) of a single session of radiofrequency ablation (Group 1), a single session of ethanol injection (Group 2), or a 6-month LT4 treatment (Group 3). Thyroid tests, including TSH, T4, T3, anti-TPO, T3RU, and serum Calcitonin level, were recorded at baseline and again at 1, 3, and six months. Nodule volume was also assessed through sonography at baseline and the other checkpoints.Results: The mean volume reduction after 6 months of intervention for ethanol injection group, radiofrequency ablation group, and LT4 treatment group were 72.2%, 83.4%, and 21.8%, respectively. There was a significant relationship between mean volume reduction and months (1, 3, and six) (P<0.001).Conclusions: Although radiofrequency ablation therapy is the best modality for managing benign thyroid nodules in our study, it is more expensive than the other modalities despite comparable therapeutic effects.

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