The THEA score in familial thyroid dysfunction. Predictive factors of autoimmune thyroid disease

2018 ◽  
Author(s):  
Grigorios Effraimidis
Keyword(s):  
Predictive Factors ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Autoimmune Thyroid

scholarly journals Prevalence of Undiagnosed Autoimmune Thyroid Disease and Thyroid Dysfunction in Filipino Patients with Autoimmune Rheumatic Disorders

2012 ◽  
Vol 27 (1) ◽  
pp. 67-71
Author(s):  
Cristina Jaring ◽  
◽  
Elizabeth Paz-Pacheco ◽  
Cecilia Jimeno ◽  
Ester Gonzales-Penserga ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Autoimmune Thyroid

scholarly journals Effects of levothyroxine treatment on pregnancy outcomes in pregnant women with autoimmune thyroid disease

2017 ◽  
Vol 176 (2) ◽  
pp. 253-265 ◽  
Author(s):  
Sima Nazarpour ◽  
Fahimeh Ramezani Tehrani ◽  
Masoumeh Simbar ◽  
Maryam Tohidi ◽  
Hamid Alavi Majd ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Outcome ◽  
Preterm Delivery ◽  
Pregnancy Outcomes ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Autoimmune Thyroid ◽  
Adverse Pregnancy ◽  
Group B

Background Despite some studies indicating that thyroid antibody positivity during pregnancy has been associated with adverse pregnancy outcomes, evidence regarding the effects of levothyroxine (LT4) treatment of euthyroid/subclinical hypothyroid pregnant women with autoimmune thyroid disease on pregnancy outcome is limited. We aimed to assess whether pregnant women with autoimmune thyroid disease, but without overt thyroid dysfunction are affected by higher rates of adverse pregnancy outcomes. In addition, we aimed to explore whether LT4 treatment improves the pregnancy outcome of affected women. Methods A prospective study was carried out on pregnant women from the first trimester to delivery. The study was conducted among pregnant women receiving prenatal care in centers under coverage of Shahid Beheshti University of Medical Sciences. Of a total of 1746 pregnant women, screened for thyroid dysfunction, 1028 euthyroid TPOAb-negative (TPOAb−) and 131 thyroid peroxidase antibody-positive (TPOAb+) women without overt thyroid dysfunction entered the second phase of the study. TPOAb+ women were randomly divided into two groups: group A (n = 65), treated with LT4 and group B (n = 66), received no treatment. The 1028 TPOAb− women (group C) served as a normal population control group. Primary outcomes were preterm delivery and miscarriage and secondary outcomes included placenta abruption, still birth, neonatal admission and neonatal TSH levels. Results Groups A and C displayed a lower rate of preterm deliveries compared with group B (RR = 0.30, 95% CI: 0.1–0.85, P = 0.0229) and (RR = 0.23, 95% CI: 0.14–0.40, P < 0.001) respectively. There was no statistically significant difference in the rates of preterm labor between groups A and C (RR = 0.79, 95% CI: 0.30–2.09, P = 0.64). The number needed to treat (NNT) for preterm birth was 5.9 (95% CI: 3.33–25.16) Conclusions Treatment with LT4 decreases the risk of preterm delivery in women who are positive for TPOAb.

Epidemiology of thyroid disease and swelling

2011 ◽  
pp. 358-370 ◽  
Author(s):  
Mark P. J. Vanderpump
Keyword(s):  
Iodine Deficiency ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Daily Intake ◽  
Urinary Iodine ◽  
Iodine Intake ◽  
Thyroid Disorders ◽  
Autoimmune Thyroid ◽  
Salt Iodization

Thyroid disorders are among the most prevalent of medical conditions. Their manifestations vary considerably from area to area and are determined principally by the availability of iodine in the diet. The limitations of epidemiological studies of thyroid disorders should therefore be borne in mind when considering the purported frequency of thyroid diseases in different communities (1). Almost one-third of the world’s population live in areas of iodine deficiency and risk the consequences despite major national and international efforts to increase iodine intake, primarily through the voluntary or mandatory iodization of salt (2). The ideal dietary allowance of iodine recommended by the WHO is 150 μ‎g iodine/day, which increases to 250 μ‎g in pregnancy and 290 μ‎g when lactating. The WHO estimates that two billion people, including 285 million school-age children still have iodine deficiency, defined as a urinary iodine excretion of less than 100 μ‎g/l. This has substantial effects on growth and development and is the most common cause of preventable mental impairment worldwide. In areas where the daily iodine intake is below 50 μ‎g, goitre is usually endemic, and when the daily intake falls below 25 μ‎g, congenital hypothyroidism is seen. The prevalence of goitre in areas of severe iodine deficiency can be as high as 80%. Iodization programmes are of proven value in reducing goitre size and in preventing goitre development and cretinism in children. Goitrogens in the diet, such as thiocyanate in incompletely cooked cassava or thioglucosides in Brassica vegetables, can explain some of the differences in prevalence of endemic goitre in areas with similar degrees of iodine deficiency. Autonomy can develop in nodular goitres leading occasionally to hyperthyroidism, and iodization programmes can also induce hyperthyroidism, especially in those aged over 40 years with nodular goitres. Autoimmune thyroiditis or hypothyroidism has not been reported to complicate salt iodization programmes. Relatively little prevalence data exist for autoimmune thyroid disease in areas of iodine deficiency (3). In iodine-replete areas, most people with thyroid disorders have autoimmune disease, ranging through primary atrophic hypothyroidism, Hashimoto’s thyroiditis, to hyperthyroidism caused by Graves’ disease. Cross-sectional studies in Europe, the USA, and Japan have determined the prevalence of hyperthyroidism, hypothyroidism, and the frequency and distribution of thyroid autoantibodies in different, mainly white, communities (1, 4–6). Recent US data have revealed differences in the frequency of thyroid dysfunction and serum antithyroid antibody concentrations in different ethnic groups (6), whereas studies from Europe have revealed the influence of dietary iodine intake on the epidemiology of thyroid dysfunction (7). Studies of incidence of autoimmune thyroid disease have only been conducted in a small number of developed countries (8–11). Following a review of the available epidemiological data, the value of screening adult populations for autoimmune thyroid disease will be considered.

Risk factors of primary thyroid dysfunction in early infants born to mothers with autoimmune thyroid disease

2007 ◽  
Vol 94 (8) ◽  
pp. 1043-1048 ◽  
Author(s):  
Junfen Fu ◽  
Youjun Jiang ◽  
Li Liang ◽  
Hong Zhu
Keyword(s):  
Risk Factors ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Autoimmune Thyroid

scholarly journals Investigation of the Prevalence of Thyroid Dysfunction, Autoimmune Thyroid Disease and Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients

2018 ◽  
Vol 38 (4) ◽  
pp. 340-347
Author(s):  
Durmuş AYAN ◽  
Nezaket EREN ◽  
Zeynep Mine YALÇINKAYA KARA ◽  
Hazım Orhan KIZILKAYA ◽  
Dönay AKSAN ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Cancer Patients ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Newly Diagnosed ◽  
Breast Cancer Patients ◽  
Autoimmune Thyroid

Thyroid dysfunction and autoimmune thyroid disease among atomic bomb survivors exposed in childhood

2018 ◽  
Author(s):  
Imaizumi M ◽  
Ohishi W ◽  
Nakashima E ◽  
Sera N ◽  
Neriishi K ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Atomic Bomb ◽  
Autoimmune Thyroid ◽  
Atomic Bomb Survivors

Thyroid Disease in Pregnancy

2008 ◽  
Vol 04 (01) ◽  
pp. 100
Author(s):  
N Pearce Elizabeth ◽  
M Leung Angela
Keyword(s):  
Pregnant Women ◽  
Thyroid Function ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Thyroid Function Test ◽  
Autoimmune Thyroid ◽  
Thyroid Screening ◽  
Function Test ◽  
In Pregnancy

The spectrum of thyroid disease in pregnancy has implications for both the mother and the developing fetus. Here we review the interpretation of thyroid function test values, thyrotoxicosis, hypothyroidism, iodine requirements, autoimmune thyroid disease, and thyroid screening recommendations as they pertain to pregnant women. It should be noted that the management of thyroid dysfunction in pregnancy should be closely co-ordinated with obstetricians and other providers.

Prevalence of autoimmune thyroid disease and thyroid dysfunction in young Brazilian patients with type 1 diabetes

2008 ◽  
Vol 9 (4pt1) ◽  
pp. 272-276 ◽  
Author(s):  
Jacqueline Araujo ◽  
Lucas AC Brandão ◽  
Rafael L Guimarães ◽  
Sérgio Santos ◽  
Elcy A Falcão ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Autoimmune Thyroid

scholarly journals Raised incidence of autoimmune thyroiditis among females in 2nd, 3rd and 4th decades: a randomized study

2019 ◽  
Vol 6 (4) ◽  
pp. 1074
Author(s):  
Rajan V. K.
Keyword(s):  
Autoimmune Thyroiditis ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Randomized Study ◽  
Thyroid Volume ◽  
Autoimmune Disorder ◽  
Autoimmune Thyroid ◽  
Organ Specific ◽  
Healthy Females

Background: Autoimmune thyroid disease (AITD), a mutual organ specific autoimmune disorder is seen mostly in women between 30-50 years of age. The rationale behind the study is to determine increased incidences of auto immune thyroiditis. The objective of the present study was to evaluate the incidence of autoimmune thyroiditis and thyroid dysfunction in healthy females with no previously known thyroid disease, in an urban area.Methods: The study was conducted on female volunteers with no known thyroid disease. 370 subjects among the hospital’s medical and administration personnel were recruited. All underwent thyroid ultrasound (US) and thyroid anti-peroxidase (TPOAb) and anti-thyroglobulin (TgAb) antibodies were measured. Hypoechogenicity and thyroid volume were determined by sonography.Results: the incidence of autoimmune thyroiditis was 23.2% and 20-30 years were most commonly affected (P = 0.008); when including cases of atrophic thyroid, the frequency decreased to 14.7%.Conclusions: The frequency of autoimmune thyroiditis is clearly elevated in the studied population. Further studies are necessary in order to define the increased incidence of autoimmune thyroid disease.

R620W polymorphism of protein tyrosine phosphatase PTPN22 in Egyptian children and adolescents with systemic lupus erythematosus: relation to thyroid autoimmunity

2013 ◽  
Vol 25 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Rasha Tarif Hamza ◽  
Khaled S. Awwad ◽  
Khaled A. Temsah ◽  
Amira I. Hamed
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Protein Tyrosine Phosphatase ◽  
Lupus Erythematosus ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Tyrosine Phosphatase ◽  
Systemic Lupus ◽  
Protein Tyrosine ◽  
Autoimmune Thyroid

Abstract Background: Some studies showed associations of the minor T allele of the C1858T single nucleotide polymorphism (SNP) corresponding to the R620W amino acid substitution of protein tyrosine phosphatase (PTPN22) with multiple autoimmune diseases, including systemic lupus erythematosus (SLE). Objectives: To study the frequency of PTPN22 R620W polymorphism among Egyptian patients with SLE and to test the association of the T allele with autoimmune thyroid disease in such patients. Methods: Clinical evaluation, measurement of thyroid hormones and antibodies, and genotyping of PTPN22 R620W polymorphism were done for 60 SLE patients and 60 age- and sex-matched healthy subjects. Results: Nineteen SLE cases (31.67%) had thyroid dysfunction with subclinical hypothyroidism being the most frequent form of thyroid dysfunction (20%) followed by primary hypothyroidism (6.67%), subclinical hyperthyroidism (3.33%) and primary hyperthyroidism (1.67%). Autoimmune thyroid disease was detected in 36.67% of cases. Systemic lupus erythematosus disease activity index (SLEDAI) score did not differ between patients with thyroid dysfunction and euthyroid patients (p=0.061) nor with the frequency of positive thyroid peroxidise antibodies (TPOAb, p=0.092) and antithyroglobulin antibodies (ATGAb, p=0.1). T allele frequency did not differ between cases and controls (p=1.19) and was associated with autoimmune thyroid disease in Egyptian SLE patients (p=0.002). Conclusions: R620W polymorphism of the PTPN22 gene is not a major risk allele for SLE susceptibility among Egyptian SLE patients but appears to be a risk factor for concurrent autoimmune thyroid disease and SLE.

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