scholarly journals Investigation of the Prevalence of Thyroid Dysfunction, Autoimmune Thyroid Disease and Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients

2018 ◽  
Vol 38 (4) ◽  
pp. 340-347
Author(s):  
Durmuş AYAN ◽  
Nezaket EREN ◽  
Zeynep Mine YALÇINKAYA KARA ◽  
Hazım Orhan KIZILKAYA ◽  
Dönay AKSAN ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Cancer Patients ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Newly Diagnosed ◽  
Breast Cancer Patients ◽  
Autoimmune Thyroid

scholarly journals Less Pathological Axillary Involvement is Observed in Breast Cancer Patients with Autoimmune Thyroid Disease

2020 ◽  
Author(s):  
SELİM YALÇIN ◽  
Ramazan Cosar ◽  
Askın Güngünes ◽  
Aydın Cifci ◽  
Senay Arikan Durmaz
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Thyroid Disease ◽  
Axillary Lymph Node ◽  
Autoimmune Thyroid Disease ◽  
Lymph Node Involvement ◽  
Axillary Lymph ◽  
Breast Cancer Patients ◽  
Autoimmune Thyroid ◽  
Axillary Lymph Node Involvement

Abstract Background: Autoimmune thyroid disease is more frequently observed in breast cancer patients. There are not enough studies showing the prognostic significance of this association in terms of breast cancer. The aim of this study was to determine the breast cancer molecular subgroup frequency and to examine the relationship between autoimmune thyroid disease and the breast cancer in terms of prognosis and predictive factors. Methods: One hundred and one patients have been included to study. They have been divided into subgroups according to molecular classification. The patients with high serum anti-thyroid peroxidase levels were considered positive for autoimmune thyroid disease. Prognostic and predictive parameters [tumor stage, tumor size, axillary lymph node involvement, histologic grade, lymphovascular , perineural invasion, hormone receptor status, HER2 (Human Epidermal Growth Receptor 2) over expression] were compared between breast cancer patients with autoimmune thyroid disease and those patients without autoimmune thyroid disease. Results: The prevalence of thyroid autoimmunity was 23.8% (n = 24) in breast cancer patients. The axillary lymph node involvement in autoimmune thyroid disease positive breast cancer patients was lower than autoimmune thyroid disease negative patients (37.5% versus 61% respectively, p = 0.043). There were no significant differences between the two groups in terms of other prognostic parameters. More importantly, there was a significantly negative correlation between anti thyroid peroxidase levels and axillary lymph node involvement in patients (r= -0.245, p=0.014). Conclusion: Positive axillary lymph nodes, have been found to be lower in breast cancer patients accompanied by autoimmune thyroid disease. This result supports the view that thyroid autoimmunity is a positive prognostic factor in terms of breast cancer. The mechanism through which it is effective should be examined in new studies. Trial registration: A written approval was granted by the Kirikkale University, Faculty of Medicine, Clinical Research Ethics Committee through the 01/09 Numbered and 19.01.2016 Dated Decision in order to conduct this study. Keywords: Thyroid autoimmune, breast cancer, prognostic factors

scholarly journals Vitamin D deficiency in newly diagnosed breast cancer patients

2012 ◽  
Vol 16 (3) ◽  
pp. 409 ◽  
Author(s):  
Saba Imtiaz ◽  
SyedAbbas Raza ◽  
Aasim Muhammad ◽  
Neelam Siddiqui ◽  
Asif Loya
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Cancer Patients ◽  
Newly Diagnosed ◽  
Breast Cancer Patients

High prevalence of vitamin D deficiency in a multi-ethnic cohort of premenopausal breast cancer patients

2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 9583-9583 ◽  
Author(s):  
K. D. Crew ◽  
E. Shane ◽  
S. Cremers ◽  
D. J. McMahon ◽  
D. Irani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Premenopausal Breast Cancer ◽  
High Prevalence

Prognostic characteristics of 492 newly diagnosed breast cancer patients by serum vitamin D levels.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e12619-e12619 ◽  
Author(s):  
Luke Joseph Peppone ◽  
Mohamedtaki Abdulaziz Tejani ◽  
Karen Michelle Mustian ◽  
Michelle Christine Janelsins ◽  
Charles Stewart Kamen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Patients ◽  
Serum Vitamin ◽  
Newly Diagnosed ◽  
Breast Cancer Patients ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Evaluation of Vitamin D Deficiency in Breast Cancer Patients on Bisphosphonates

2008 ◽  
Vol 13 (7) ◽  
pp. 821-827 ◽  
Author(s):  
Andrea Wang‐Gillam ◽  
Dorothy A. Miles ◽  
Laura F. Hutchins
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Cancer Patients ◽  
Breast Cancer Patients

P5-05-01: Vitamin D Status in Newly Diagnosed Breast Cancer Patients Inversely Correlates with Tumor Size and Moderately Correlates with Outcome.

2011 ◽  
Author(s):  
S Hatse ◽  
D Lambrechts ◽  
M Verstuyf ◽  
A Smeets ◽  
B Brouwers ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Patients ◽  
Tumor Size ◽  
Vitamin D Status ◽  
Newly Diagnosed ◽  
Breast Cancer Patients

Breast cancer and vitamin D in postmenopausal minorities.

2012 ◽  
Vol 30 (27_suppl) ◽  
pp. 17-17
Author(s):  
Demet Gokalp Yasar ◽  
Pam Khosla
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Cancer Patients ◽  
Bone Health ◽  
Postmenopausal Breast Cancer ◽  
Cancer Information ◽  
Minority Population ◽  
Breast Cancer Patients ◽  
Significant Difference

17 Background: Bone health is a particular concern for breast cancer survivors, because these women have 15% higher fracture risk than women without a history of breast cancer. Many studies have suggested that vitamin D deficiency may be involved in breast cancer initiation, progression, and prognosis. This study examines the prevalence of vitamin D deficiency among postmenopausal breast cancer patients in minority population. Methods: This retrospective study reviewed the electronic records of 200 postmenopausal breast cancer patients from ethnic groups of blacks, Hispanics and Asians. Results: Of the 200 patients, 84 (42%) had their 25-OHD levels checked at least once. Of patients, 42.7% found body mass index (BMI)>30kg/m2. There was significant difference between race and BMI (p<0.05). Black Vitamin D deficiency (level< 20ng/mL) found in 35 (41.7%), vitamin D insufficiency (level range 20-30ng/mL) found in 30 (35.7%) of the patients. The median serum 25-OHD level was 21 (range 4-65ng/ml). The serum 25-OHD levels did not have significant difference among blacks and Hispanics. Tumor stages found negatively correlated with 25-OHD levels r=-0.227 and p=0.04. Conclusions: This study revealed that vitamin D deficiency has a high prevalence among postmenopausal breast cancer minority population. Data from Third National Health and Nutrition Examination survey showed that mean serum 25-OHD levels among white, Hispanic and black women were 76ng/ml, 56.7ng/ml and 45.3ng/ml, respectively. Also, prevalence rate of vitamin D deficiency is reported in the studies among breast cancer patients are approximately 30%. Our data compared with this general population’s numbers is low; our median 25-OHD level was 21ng/ml. Our study found negative correlation with Vitamin D levels and stages of the breast cancer. Information is lacking on direct prognostic effect of vitamin D in breast cancer but this findings including our study support the hypothesis that vitamin D has a role in the pathogenesis of breast cancer. In the setting of breast cancer diagnosis either for bone health, or for breast cancer prognosis in postmenopausal women, we advocate routine 25-OHD levels screening for the vitamin D deficiency especially in minority populations would be beneficial.

Is vitamin D deficiency in breast cancer patients associated with aggressive prognosis?

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e12511-e12511
Author(s):  
Omalkhair A. M. Abulkhair ◽  
Ahmed Gasmelseed ◽  
Ola Makram ◽  
Ahmed Saadeddin ◽  
Ahmed Hashim Mohamed
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Cancer Patients ◽  
Breast Cancer Patients
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