scholarly journals Emerging roles of steroid receptor coactivators in stromal cell responses

2020 ◽  
Author(s):  
Aarti D Rohira ◽  
David M. Lonard ◽  
Bert W O'Malley
Keyword(s):  
Stromal Cell ◽  
Protein Complexes ◽  
Steroid Receptor ◽  
Signaling Cascades ◽  
Cellular Transcription Factor ◽  
Steroid Receptor Coactivator ◽  
Cell Components ◽  
Steroid Receptor Coactivators ◽  
Transcription Factor Signaling

Tissue parenchyma is the functional unit of an organ and all of the remaining cells within that organ collectively make up the tissue stroma. The stroma includes fibroblasts, endothelial cells, immune cells, and nerves. Interactions between stromal and epithelial cells are essential for tissue development and healing after injury. These interactions are governed by growth factors, inflammatory cytokines and hormone signaling cascades. The steroid receptor coactivator (SRC) family of proteins includes 3 transcriptional coactivators that facilitate the assembly of multi-protein complexes to induce gene expression in response to activation of many cellular transcription factor signaling cascades. They are ubiquitously expressed and are especially critical for the developmental function of steroid hormone responsive tissues. The SRCs are overexpressed in multiple cancers including breast, ovarian, prostate and endometrial cancers. In this review, we focus on the role of the SRCs in regulating the functions of stromal cell components responsible for angiogenesis, inflammation and cell differentiation.

scholarly journals Steroid Receptor Coactivator 2 is Required for Female Fertility and Mammary Morphogenesis: Insights from the Mouse, Relevance to the Human

2007 ◽  
Vol 5 (1) ◽  
pp. nrs.05011 ◽  
Author(s):  
Atish Mukherjee ◽  
Paula Amato ◽  
D. Craig Allred ◽  
Francesco J. DeMayo ◽  
John P. Lydon
Keyword(s):  
Mammary Gland ◽  
Gene Knockout ◽  
Embryo Implantation ◽  
Cell Types ◽  
Steroid Receptor ◽  
Branching Morphogenesis ◽  
Mammary Epithelial ◽  
Signaling Cascades ◽  
Steroid Receptor Coactivator ◽  
Female Reproductive Health

Although the importance of the progesterone receptor (PR) to female reproductive and mammary gland biology is firmly established, the coregulators selectively co-opted by PR in these systems have not been clearly delineated. A selective gene-knockout approach applied to the mouse, which abrogates gene function only in cell types that express PR, recently disclosed steroid receptor coactivator 2 (SRC-2, also known as TIF-2 or GRIP-1) to be an indispensable coregulator for uterine and mammary gland responses that require progesterone. Uterine cells positive for PR (but devoid of SRC-2) were found to be incapable of facilitating embryo implantation, a necessary first step toward the establishment of the materno-fetal interface. Importantly, such an implantation defect is not exhibited by knockouts for SRC-1 or SRC-3, underscoring the unique coregulator importance of SRC-2 in peri-implantation biology. Moreover, despite normal levels of PR, SRC-1 and SRC-3, progesterone-dependent branching morphogenesis and alveologenesis fails to occur in the murine mammary gland in the absence of SRC-2, thereby establishing a critical coregulator role for SRC-2 in signaling cascades that mediate progesterone-induced mammary epithelial proliferation. Finally, the recent detection of SRC-2 in the human endometrium and breast suggests that this coregulator may represent a new clinical target for the future management of female reproductive health and/or breast cancer.

scholarly journals The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease

2010 ◽  
Vol 36 (3) ◽  
pp. 224-229 ◽  
Author(s):  
O. Gojis ◽  
B. Rudraraju ◽  
C. Alifrangis ◽  
J. Krell ◽  
P. Libalova ◽  
...  
Keyword(s):  
Malignant Disease ◽  
Steroid Receptor ◽  
Steroid Receptor Coactivator

scholarly journals Role of the Promyelocytic Leukemia Body in the Dynamic Interaction between the Androgen Receptor and Steroid Receptor Coactivator-1 in Living Cells

2003 ◽  
Vol 17 (1) ◽  
pp. 128-140 ◽  
Author(s):  
Omar J. Rivera ◽  
Chung S. Song ◽  
Victoria E. Centonze ◽  
James D. Lechleiter ◽  
Bandana Chatterjee ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Steroid Receptor ◽  
Living Cells ◽  
Dynamic Interaction ◽  
Promyelocytic Leukemia ◽  
Steroid Receptor Coactivator

scholarly journals SRC-3, a Steroid Receptor Coactivator: Implication in Cancer

2021 ◽  
Vol 22 (9) ◽  
pp. 4760
Author(s):  
Licen Li ◽  
Chu-Xia Deng ◽  
Qiang Chen
Keyword(s):  
Breast Cancer ◽  
Transcription Factors ◽  
Cancer Therapy ◽  
Nuclear Receptors ◽  
Essential Role ◽  
Transcriptional Activity ◽  
Steroid Receptor ◽  
Steroid Receptor Coactivator ◽  
Important Progress

Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), is a member of the SRC family. SRC-3 regulates not only the transcriptional activity of nuclear receptors but also many other transcription factors. Besides the essential role of SRC-3 in physiological functions, it also acts as an oncogene to promote multiple aspects of cancer. This review updates the important progress of SRC-3 in carcinogenesis and summarizes its mode of action, which provides clues for cancer therapy.

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