scholarly journals Ovarian sex steroid receptors and sex hormones in androgenized rats

Reproduction ◽  
2016 ◽  
Vol 152 (5) ◽  
pp. 545-559 ◽  
Author(s):  
Vinícius Augusto Simão ◽  
Luiz Gustavo de Almeida Chuffa ◽  
Isabel Cristina Cherici Camargo
Keyword(s):  
Sex Hormones ◽  
Steroid Receptors ◽  
Serum Levels ◽  
Sex Steroid ◽  
Control Group ◽  
Dependent Manner ◽  
Adult Rats ◽  
Sex Steroid Receptors ◽  
17Β Estradiol ◽  
First Time

This study evaluated for the first time the effects of different doses of the anabolic steroid nandrolone decanoate (ND) on the expression of ovarian steroid receptors (AR, ER-α (ESR1) and ER-β (ESR2)) and related sex hormones after treatment and recovery periods in adult rats. The animals were injected subcutaneously with doses of ND (1.87, 3.75, 7.5 or 15 mg/kg b.w.) or mineral oil (control group) for 15 days, and the experimental groups were divided into three periods of evaluation: (a) ND treatment for 15 days, (b) ND treatment and recovery for a period of 30 days and (c) ND treatment and recovery for a period of 60 days. Estrous cycle was monitored daily. At the end of each period, rats were killed for collection of blood and ovaries. Persistent diestrus occurred in all rats during ND treatment and after 30-day recovery. The highest dose of ND was able to maintain all rats arrested at diestrus until 60-day recovery. The expression of steroid receptors varied in a dose- and period-dependent manner, having a more pronounced response with the dose of 15 mg ND/kg. ND treatment increased serum levels of testosterone, 17β-estradiol and dihydrotestosterone, especially at the highest doses of 7.5 and 15 mg ND/kg. No change was observed in the levels of follicle-stimulating hormone (FSH), whereas levels of the luteinizing hormone (LH) varied according to the dose and period. In conclusion, the ovarian sex steroid receptors and sex hormones were restored only at lower doses of ND and after a longer period of recovery.

Melatonin and ethanol intake exert opposite effects on circulating estradiol and progesterone and differentially regulate sex steroid receptors in the ovaries, oviducts, and uteri of adult rats

2013 ◽  
Vol 39 ◽  
pp. 40-49 ◽  
Author(s):  
Luiz Gustavo A. Chuffa ◽  
Fábio R.F. Seiva ◽  
Wagner José Fávaro ◽  
João Paulo A. Amorim ◽  
Giovana R. Teixeira ◽  
...  
Keyword(s):  
Steroid Receptors ◽  
Ethanol Intake ◽  
Sex Steroid ◽  
Adult Rats ◽  
Sex Steroid Receptors

Nandrolone decanoate causes uterine injury by changing hormone levels and sex steroid receptors in a dose- and time-dependent manner

2021 ◽  
Author(s):  
Vinícius Augusto Simão ◽  
Luiz Antonio Lupi Júnior ◽  
Gabriel Adan Araujo Leite ◽  
Isabel Cristina Cherici Camargo ◽  
Luiz Gustavo de Almeida Chuffa
Keyword(s):  
Steroid Receptors ◽  
Time Dependent ◽  
Sex Steroid ◽  
Dependent Manner ◽  
Nandrolone Decanoate ◽  
Hormone Levels ◽  
Sex Steroid Receptors

scholarly journals P-96 Levels of sex hormones and sex steroid receptors in pathological tissues in gastric cancer patients

2020 ◽  
Vol 31 ◽  
pp. S120-S121
Author(s):  
O. Kit ◽  
E. Frantsiyants ◽  
V. Bandovkina ◽  
Y. Gevorkyan ◽  
N. Soldatkina ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Sex Hormones ◽  
Steroid Receptors ◽  
Sex Steroid ◽  
Sex Steroid Receptors ◽  
Gastric Cancer Patients ◽  
Pathological Tissues

Antagonism by Progesterone of Diethylstilbestrol-lnduced Pituitary Tumorigenesis in Fischer 344 Rats: Effects on Sex Steroid Receptors and Tyrosine Hydroxylase mRNA

1996 ◽  
Vol 63 (6) ◽  
pp. 530-539 ◽  
Author(s):  
Gerardo G. Piroli ◽  
Claudia A. Grillo ◽  
Monica G. Ferrini ◽  
Victoria Lux-Lantos ◽  
Alejandro F. De Nicola
Keyword(s):  
Tyrosine Hydroxylase ◽  
Steroid Receptors ◽  
Sex Steroid ◽  
Fischer 344 Rats ◽  
Fischer 344 ◽  
Sex Steroid Receptors ◽  
Pituitary Tumorigenesis

484 Sex steroid receptors in 53 human CNS neuroepithelial tumors

1983 ◽  
Vol 19 ◽  
pp. 166
Author(s):  
J. Hassoun ◽  
P.M. Martin ◽  
R.P. Vigouroux ◽  
M. Toga ◽  
M. Moguilewsky ◽  
...  
Keyword(s):  
Steroid Receptors ◽  
Sex Steroid ◽  
Neuroepithelial Tumors ◽  
Sex Steroid Receptors

scholarly journals Evaluation of the Relationship between the Level of DHEA-S and Sex Hormones in Some Infertile Iraqi Men

2021 ◽  
Vol 8 (5) ◽  
pp. 130-136
Author(s):  
Khaled S. Abd ◽  
Adnan F. AL-Azzawie
Keyword(s):  
Sex Hormones ◽  
Seminal Fluid ◽  
Age Groups ◽  
Serum Levels ◽  
Dehydroepiandrosterone Sulfate ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Infertile Men ◽  
The Relationship

This study aims to evaluate serum levels of the Dehydroepiandrosterone sulfate (DHEA-S) and its relationship with some sex hormones such as Follicle stimulating hormone (FSH), Luteinizing hormone (LH), prolactin and testosterone hormone and the infertility type in some infertile Iraqi men. Blood and seminal fluid samples from (60) idiopathic male infertile and (60) healthful individuals as a control group aged (18 to 60 year) were collected from private clinics. Serum hormones (DHEA-S, FSH, LH, prolactin and testosterone) were measurement using Enzyme Linked Immunosorbent Assay (ELISA). The levels of DHEA-S, FSH, LH and prolactin are significantly higher (P≤0.01) expect of the testosterone level was significantly decreased (P≤ 0.01) in the infertile men as compared with control group. High significant differences (P≤0.01) were recorded when comparing the hormonal levels (DHEA-S, FSH, LH, prolactin and testosterone) according to the age groups. There are significant differences (P≤ 0.01) in levels of (DHEA-S, FSH, LH, prolactin and testosterone) in the infertility period.  Smoker infertile men have high levels (P≤ 0.05) in the DHEA-S and LH while have low levels in the prolactin hormones compared with control. Patients with family history have shown significant differences (P≤0.05) in the levels of DHEA-S, FSH, LH and prolactin. In conclusion, this study revealed significantly increase in the DHEA-S levels in the infertile men and negative correlation between DHEA-S and FSH. Therefore, DHEA-S has important role in the diagnosis and follow up of the male infertility.

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