scholarly journals Expression of Heat Shock Protein 70 Is Insufficient To Extend Drosophila melanogaster Longevity

2019 ◽  
Vol 9 (12) ◽  
pp. 4197-4207 ◽  
Author(s):  
Chengfeng Xiao ◽  
Danna Hull ◽  
Shuang Qiu ◽  
Joanna Yeung ◽  
Jie Zheng ◽  
...  
1986 ◽  
Vol 83 (22) ◽  
pp. 8713-8717 ◽  
Author(s):  
A. E. Bianco ◽  
J. M. Favaloro ◽  
T. R. Burkot ◽  
J. G. Culvenor ◽  
P. E. Crewther ◽  
...  

2019 ◽  
Author(s):  
Chengfeng Xiao ◽  
Danna Hull ◽  
Shuang Qiu ◽  
Joanna Yeung ◽  
Jie Zheng ◽  
...  

AbstractIt has been known for over 20 years that Drosophila melanogaster flies with twelve additional copies of the hsp70 gene encoding the 70 kDa heat shock protein lives longer after a non-lethal heat treatment. Since the heat treatment also induces the expression of additional heat shock proteins, the biological effect can be due either to HSP70 acting alone or in combination. This study used the UAS/GAL4 system to determine whether hsp70 is sufficient to affect the longevity and the resistance to thermal, oxidative or desiccation stresses of the whole organism. We observed that HSP70 expression in the nervous system or muscles has no effect on longevity or stress resistance but ubiquitous expression reduces the life span of males. We also observed that the down-regulation of Hsp70 using RNAi did not affect longevity.


2010 ◽  
Vol 242 (3) ◽  
pp. 263-269 ◽  
Author(s):  
Maqusood Ahamed ◽  
Ryan Posgai ◽  
Timothy J. Gorey ◽  
Mark Nielsen ◽  
Saber M. Hussain ◽  
...  

2001 ◽  
Vol 120 (5) ◽  
pp. A152-A152
Author(s):  
H SUZUKI ◽  
S NAGAHASHI ◽  
M MIYAZAWA ◽  
M MORI ◽  
H NAGATA ◽  
...  

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