Fitness Costs and Variation in Transmission Distortion Associated with the Abnormal Chromosome 10 Meiotic Drive System in Maize

Abstract We provide a genetic analysis of the meiotic drive system on maize abnormal chromosome 10 (Ab10) that causes preferential segregation of specific chromosomal regions to the reproductive megaspore. The data indicate that at least four chromosomal regions contribute to meiotic drive, each providing distinct functions that can be differentiated from each other genetically and/or phenotypically. Previous reports established that meiotic drive requires neocentromere activity at specific tandem repeat arrays (knobs) and that two regions on Ab10 are involved in trans-activating neocentromeres. Here we confirm and extend data suggesting that only one of the neocentromere-activating regions is sufficient to move many knobs. We also confirm the localization of a locus/loci on Ab10, thought to be a prerequisite for meiotic drive, which promotes recombination in structural heterozygotes. In addition, we identified two new and independent functions required for meiotic drive. One was identified through the characterization of a deletion derivative of Ab10 [Df(L)] and another as a newly identified meiotic drive mutation (suppressor of meiotic drive 3). In the absence of either function, meiotic drive is abolished but neocentromere activity and the recombination effect typical of Ab10 are unaffected. These results demonstrate that neocentromere activity and increased recombination are not the only events required for meiotic drive.

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Faculty Opinions recommendation of Centromere-associated female meiotic drive entails male fitness costs in monkeyflowers.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1144856.601943 ◽

2009 ◽

Author(s):

Leonie Moyle

Keyword(s):

Meiotic Drive ◽

Male Fitness ◽

Fitness Costs

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Chromosome 10 Abnormality Predicts Prognosis of Neuroblastoma Patients With Bone Marrow Metastasischromosome 10 Abnormality Predicts Prognosis of Neuroblastoma Patients With Bone Marrow Metastasis

10.21203/rs.3.rs-146698/v1 ◽

2021 ◽

Author(s):

Chiyi Jiang ◽

Xiao Xu ◽

Binglin Jian ◽

Xue Zhang ◽

Zhixia Yue ◽

...

Keyword(s):

Bone Marrow ◽

Clinical Characteristics ◽

Chromosomal Abnormalities ◽

Abnormal Chromosome ◽

Mycn Amplification ◽

Chromosome 10 ◽

Orbital Metastases ◽

One Year ◽

The Relationship

Abstract Background Neuroblastoma (NB) is the most common extracranial solid tumor in children with high heterogeneity and concealed onset. The mechanism for its occurrence and development has not been revealed. The purpose of this study was to summarize the clinical characteristics of children with NB and abnormal chromosome 10. To investigate the relationship between the number and structure of chromosome 10 abnormality and NB prognosis.MethodsWe used chromosome G-banding in the first diagnosis to evaluate the genetics of chromosomes in patients with NB, and follow up their clinical characteristics and prognosis. All participants were diagnosed with NB in Hematology Oncology Center, Beijing Children’s Hospital from May 2015 to December 2018, and were followed up for at least one year. ResultsOf all 150 patients with bone marrow metastases, 42 were clearly diagnosed with chromosomal abnormalities. There were 13 patients with chromosome 10 abnormalities definitely, and the loss of chromosome 10 was the most common decrease in the number of chromosomes. These 13 patient had higher LDH, lower OS and EFS than that of children in abnormal group without chromosome 10 abnormality. Eight patients both had MYCN amplification and 1p36 deletion. Two of them had optic nerve damage and no vision, and 1 had left supraorbital metastases five months after treatment. Among the 16 children with suspected chromosome 10 abnormalities, 3 also had orbital metastases. ConclusionsThe above results showed that chromosome 10 might be a new prognostic marker. MYCN amplification and 1p36 deletion may be related with chromosome 10 abnormalities in NB. And NB patients with abnormal chromosome 10 were prone to have orbital metastases.

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Transmission Distortion Affecting Human Noncrossover but Not Crossover Recombination: A Hidden Source of Meiotic Drive

PLoS Genetics ◽

10.1371/journal.pgen.1004106 ◽

2014 ◽

Vol 10 (2) ◽

pp. e1004106 ◽

Cited By ~ 35

Author(s):

Linda Odenthal-Hesse ◽

Ingrid L. Berg ◽

Amelia Veselis ◽

Alec J. Jeffreys ◽

Celia A. May

Keyword(s):

Meiotic Drive ◽

Transmission Distortion

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The Maize Ab10 Meiotic Drive System Maps to Supernumerary Sequences in a Large Complex Haplotype

Genetics ◽

10.1534/genetics.105.048322 ◽

2006 ◽

Vol 174 (1) ◽

pp. 145-154 ◽

Cited By ~ 22

Author(s):

Rebecca J. Mroczek ◽

Juliana R. Melo ◽

Amy C. Luce ◽

Evelyn N. Hiatt ◽

R. Kelly Dawe

Keyword(s):

Meiotic Drive ◽

Drive System ◽

Large Complex ◽

System Maps

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BANDING PATTERNS IN MAIZE MITOTIC CHROMOSOMES

Canadian Journal of Genetics and Cytology ◽

10.1139/g80-009 ◽

1980 ◽

Vol 22 (1) ◽

pp. 61-67 ◽

Cited By ~ 28

Author(s):

E. J. Ward

Keyword(s):

Zea Mays ◽

Chromosome Banding ◽

Zea Mays L ◽

B Chromosomes ◽

Abnormal Chromosome ◽

Root Tip ◽

Mitotic Chromosomes ◽

Chromosome 10 ◽

Banding Patterns

A procedure for chromosome banding in triticale has been shown to be equally effective on maize, Zea mays L., root tip chromosomes. Stocks of known knob constitution were used to demonstrate that differentially stained regions of C-banded mitotic chromosomes corresponded with knobs. The large knob and prominent chromomeres of abnormal chromosome 10 were also differentiated, as was the centric heterochromatin of B chromosomes. However, the large distal heterochromatic portion of the B was not differentiated by the procedure.

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Distribution of Retroelements in Centromeres and Neocentromeres of Maize

Genetics ◽

10.1093/genetics/165.2.809 ◽

2003 ◽

Vol 165 (2) ◽

pp. 809-819 ◽

Cited By ~ 4

Author(s):

Rebecca J Mroczek ◽

R Kelly Dawe

Keyword(s):

In Situ Hybridization ◽

Long Terminal Repeat ◽

Fluorescent In Situ Hybridization ◽

Staining Intensity ◽

Abnormal Chromosome ◽

Chromosome 10 ◽

Centromere Function ◽

Intensity Measurements ◽

Ltr Retroelements

AbstractFluorescent in situ hybridization was used to examine the distribution of six abundant long terminal repeat (LTR) retroelements, Opie, Huck, Cinful-1, Prem-2/Ji, Grande, and Tekay/Prem-1 on maize pachytene chromosomes. Retroelement staining in euchromatin was remarkably uniform, even when we included the structurally polymorphic abnormal chromosome 10 (Ab10) in our analysis. This uniformity made it possible to use euchromatin as a control for quantitative staining intensity measurements in other regions of the genome. The data show that knobs, known to function as facultative neocentromeres when Ab10 is present, tend to exclude retroelements. A notable exception is Cinful-1, which accumulates in TR-1 knob arrays. Staining for each of the six retroelements was also substantially reduced in centromeric satellite arrays to an average of 30% of the staining in euchromatin. This contrasted with two previously described centromere-specific retrotransposable (CR) elements that were readily detected in centromeres. We suggest that retroelements are relatively rare in centromeres because they interrupt the long satellite arrays thought to be required for efficient centromere function. CR elements may have evolved mutualistic relationships with their plant hosts: they are known to interact with the kinetochore protein CENH3 and appear to accumulate in clusters, leaving long satellite arrays intact.

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Distinct spermiogenic phenotypes underlie sperm elimination in the Segregation Distorter meiotic drive system

PLoS Genetics ◽

10.1371/journal.pgen.1009662 ◽

2021 ◽

Vol 17 (7) ◽

pp. e1009662

Author(s):

Marion Herbette ◽

Xiaolu Wei ◽

Ching-Ho Chang ◽

Amanda M. Larracuente ◽

Benjamin Loppin ◽

...

Keyword(s):

Drosophila Melanogaster ◽

Satellite Dna ◽

Copy Number ◽

Meiotic Drive ◽

Drive System ◽

Sperm Chromatin ◽

Cellular Mechanisms ◽

Segregation Distorter ◽

Sperm Nuclei ◽

Very High

Segregation Distorter (SD) is a male meiotic drive system in Drosophila melanogaster. Males heterozygous for a selfish SD chromosome rarely transmit the homologous SD+ chromosome. It is well established that distortion results from an interaction between Sd, the primary distorting locus on the SD chromosome and its target, a satellite DNA called Rsp, on the SD+ chromosome. However, the molecular and cellular mechanisms leading to post-meiotic SD+ sperm elimination remain unclear. Here we show that SD/SD+ males of different genotypes but with similarly strong degrees of distortion have distinct spermiogenic phenotypes. In some genotypes, SD+ spermatids fail to fully incorporate protamines after the removal of histones, and degenerate during the individualization stage of spermiogenesis. In contrast, in other SD/SD+ genotypes, protamine incorporation appears less disturbed, yet spermatid nuclei are abnormally compacted, and mature sperm nuclei are eventually released in the seminal vesicle. Our analyses of different SD+ chromosomes suggest that the severity of the spermiogenic defects associates with the copy number of the Rsp satellite. We propose that when Rsp copy number is very high (> 2000), spermatid nuclear compaction defects reach a threshold that triggers a checkpoint controlling sperm chromatin quality to eliminate abnormal spermatids during individualization.

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