Storage Time of Filtered Red Blood Cells and Post-Transfusion Complications (Review)

Red blood cells are the most required blood transfusion products worldwide. Safety and efficacy of blood transfusion are still relevant issues. Clarification of the causes and mechanisms of post-transfusion complications requires additional research.Aim of the review is to summarize the data of clinical and research studies on transfusion of red blood cell suspension with various storage times.Material. We selected 76 sources from Web of Science, Scopus, and RSCI databases containing pertinent clinical and scientific research data, as well as blood transfusion guidelines.Results. We reviewed the main stages of preparation and storage of filtered red blood cells, described biochemical and structural alterations occurring during blood storage, summarized clinical data on post-transfusion complications, and analyzed clinical consequences and molecular structure abnormalities of red blood cells in relation to their storage time.Conclusion. During long-term storage, red blood cells undergo significant structural and metabolic changes. The clinical use of relatively «old» red blood cells increases the risk of post-transfusion complications. However, the pathophysiological differences between «young» and «old» erythrocytes remain unclear. Large clinical and molecular research studies may add to our understanding of the complex issues related to blood transfusion.

Download Full-text

Guidelines for Red Blood Cells and Plasma Transfusion for Adults and Children: An Emergency Physician's Overview of the 1997 Canadian Blood Transfusion Guidelines

Journal of Emergency Medicine ◽

10.1016/s0736-4679(97)00253-9 ◽

1998 ◽

Vol 16 (1) ◽

pp. 129-132 ◽

Cited By ~ 14

Author(s):

Grant Innes

Keyword(s):

Blood Transfusion ◽

Red Blood Cells ◽

Blood Cells ◽

Plasma Transfusion ◽

Adults And Children ◽

Transfusion Guidelines

Download Full-text

Do erythropoietin and a blood transfusion guideline reduce the amount of packed red blood cells transfused in a major teaching hospital?

CHEST Journal ◽

10.1378/chest.126.4_meetingabstracts.871s-b ◽

2004 ◽

Vol 126 (4) ◽

pp. 871S

Author(s):

Nam T. Ly ◽

Brian Cuneo ◽

William L. Jackson ◽

Nagla Wahab ◽

Linda Gery ◽

...

Keyword(s):

Blood Transfusion ◽

Red Blood Cells ◽

Teaching Hospital ◽

Blood Cells ◽

Packed Red Blood Cells ◽

Major Teaching Hospital ◽

Major Teaching

Download Full-text

Retrolental Fibroplasia and Blood Transfusion in Very Low-Birth-Weight Infants

PEDIATRICS ◽

10.1542/peds.68.6.770 ◽

1981 ◽

Vol 68 (6) ◽

pp. 770-774 ◽

Cited By ~ 1

Author(s):

Linda M. Sacks ◽

David B. Schaffer ◽

Endla K. Anday ◽

George J. Peckham ◽

Maria Delivoria-Papadopoulos

Keyword(s):

Birth Weight ◽

Blood Transfusion ◽

Low Birth Weight ◽

Red Blood Cells ◽

Blood Cells ◽

Very Low Birth Weight ◽

Statistical Significance ◽

Low Birth Weight Infants ◽

Retrolental Fibroplasia ◽

Packed Red Blood Cells

The relative contribution of transfusions of adult blood to the development of retrolental fibroplasia (RLF) in very low-birth-weight infants was examined. Five years of experience with the expanded use of replacement and exchange transfusions in 90 infants with birth weight ≤1,250 gm was reviewed. Twenty percent of the infants developed cicatricial RLF. Exchange transfusion was not related to development of cicatricial RLF. The incidence of RLF in infants receiving ≥130 ml of packed red blood cells per kilogram of birth weight as replacement blood transfusion (RBT) was significantly higher (42.9%) than that in infants receiving 61 to 131 ml of packed red blood cells per kilogram (15.4%) and infants receiving ≤60 ml of packed red blood cells per kilogram (0%), P < .001. The need for RBT, however, was strongly correlated (r = .85, P < .001) with increasing duration of O2 therapy. When O2 therapy was controlled for, the association between RBT and RLF did not achieve statistical significance (P = .07). The association between RBT and RLF remained significant when adjusted for duration of therapy in fractional inspired oxygen (FIO2) >0.4. Further detailed studies of large numbers of susceptible infants are warranted to assess the magnitude of the contribution of transfusions of adult blood to development of RLF.

Download Full-text

Using Redox Potential as a Feasible Marker for Banked Blood Quality and the State of Oxidative Stress in Stored Red Blood Cells

10.21203/rs.3.rs-104378/v1 ◽

2020 ◽

Author(s):

Rodney C Daniels ◽

Hyesun Jun ◽

Robertson D Davenport ◽

Maryanne M Collinson ◽

Kevin R Ward

Keyword(s):

Oxidative Stress ◽

Redox Potential ◽

Red Blood Cells ◽

Healthy Volunteers ◽

Blood Cells ◽

Storage Time ◽

Cell Function ◽

Venous Blood ◽

Functional Changes ◽

Over Time

Abstract Background Stored Red Blood Cells (RBCs) may undergo oxidative stress over time, with functional changes affecting critical tasks such as oxygen delivery. Central to these changes are oxidation-reduction (redox) reactions and the redox potential (RP) that must be maintained for proper cell function. RP imbalance can lead to oxidative stress that may contribute to storage lesions and transfusion-related morbidities. Direct measures of RP may allow for evaluation of erythrocyte quality and enable corrections of RP prior to transfusion. Methods Multiple random RBC segments were tested, ranging in age from 5 to 40 days at 5 day intervals. RP was recorded by measuring open circuit potential of RBCs using novel nanoporous gold electrodes with Ag/AgCl reference. RP measures were also performed on peripheral venous blood samples from 10 healthy volunteers. RP measures were compared between groups of aged RBCs, and with volunteer blood. Results Stored RBCs show time-dependent increases in RP. There were significant differences in Day 5 RP compared to all other groups (p≤0.005), Day 10-15 vs ages ≥ Day 20 (p≤0.025), Day 20-25 vs Day 40 (p=0.039), and all groups compared to healthy volunteers. RP became more positive over time suggesting ongoing oxidation as RBCs age. However, storage time alone does not predict the ultimate RP value measured from a given unit.Conclusions There are significant differences in RP between freshly stored RBCs and all others, with RP becoming more positive over time. However, storage time alone does not predict RP, indicating RP screening may be important independent of storage time and may serve as a marker of RBC quality and state of oxidative stress. RP measurements may also provide a target by which to restore RP balance in aged pRBCs, improving their clinical effectiveness while reducing associated morbidities.

Download Full-text

Storage time of allogeneic red blood cells is associated with risk of severe postoperative infection after coronary artery bypass grafting☆

European Journal of Cardio-Thoracic Surgery ◽

10.1016/j.ejcts.2010.06.019 ◽

2011 ◽

Vol 39 (3) ◽

pp. 329-334 ◽

Cited By ~ 45

Author(s):

Jan Jesper Andreasen ◽

Claus Dethlefsen ◽

Ivy S. Modrau ◽

John Baech ◽

Henrik C. Schonheyder ◽

...

Keyword(s):

Coronary Artery ◽

Coronary Artery Bypass Grafting ◽

Red Blood Cells ◽

Coronary Artery Bypass ◽

Blood Cells ◽

Postoperative Infection ◽

Storage Time ◽

Artery Bypass ◽

Bypass Grafting ◽

Artery Bypass Grafting

Download Full-text

Effects of shorter versus longer storage time of transfused red blood cells in adult ICU patients: a systematic review with meta-analysis and Trial Sequential Analysis

Intensive Care Medicine ◽

10.1007/s00134-018-5069-0 ◽

2018 ◽

Vol 44 (2) ◽

pp. 204-217 ◽

Cited By ~ 14

Author(s):

Sofie L. Rygård ◽

Andreas B. Jonsson ◽

Martin B. Madsen ◽

Anders Perner ◽

Lars B. Holst ◽

...

Keyword(s):

Systematic Review ◽

Red Blood Cells ◽

Blood Cells ◽

Storage Time ◽

Sequential Analysis ◽

Meta Analysis ◽

Trial Sequential Analysis ◽

Icu Patients

Download Full-text

Rejuvenation capacity of red blood cells in additive solutions over long-term storage

Transfusion ◽

10.1111/j.1537-2995.2010.03021.x ◽

2011 ◽

Vol 51 (7) ◽

pp. 1574-1579 ◽

Cited By ~ 26

Author(s):

Erin K. Meyer ◽

Deborah F. Dumont ◽

Sharry Baker ◽

Larry J. Dumont

Keyword(s):

Red Blood Cells ◽

Blood Cells ◽

Long Term Storage ◽

Term Storage

Download Full-text

Erythroplateletapheresis: A New Strategy in the Global Apheresis Program

The International Journal of Artificial Organs ◽

10.1177/039139889802106s03 ◽

1998 ◽

Vol 21 (6_suppl) ◽

pp. 17-19

Author(s):

G. Menichella ◽

M. Ciarli ◽

R. Serafini ◽

L. Pierelli ◽

M. Vittori ◽

...

Keyword(s):

Blood Cell ◽

Red Blood Cells ◽

Plasma Volume ◽

Blood Cells ◽

Storage Time ◽

Blood Donation ◽

Mean Values ◽

Packed Red Blood Cells ◽

New Strategy ◽

The Mean

Blood donation allowed by cell separators can offer higher performance and higher yield to guarantee better quality and pureness of collected products. New systems for the collection of platelet concentrate (PC) and packed red blood cells (PRBC) are currently available. The aim of our work was to test the possibility of preparing PC routinely from normal apheresis donors in a minimum amount of time while providing a second product. Over a 3-month period we performed 40 procedures using the Hemonetics MCS3P blood cell separator and the Dideco Excel. The mean values of platelet yield were 2.8 x 1011 (range 1.4-4.1) with the MCS3P and 3.49 x 1011 (range 2.9-3.9) with the Excel, in a plasma volume of 240 ml and 215 ml respectively; the PRBC units were added with SAG-Mannitol allowing a storage time of 42 days. Collection times were 71’ and 48’ respectively. Donor tolerance was analogous to phateletapheresis or plasmapheresis.

Download Full-text