Vitamin B12 and/or Folate Deficiency is a Cause of Macro Thrombocytopenia

2015 ◽  
Vol 2 (2) ◽  
pp. 20-24
Author(s):  
Anupama Jaggia ◽  
◽  
Adrian Northern
Keyword(s):  
Vitamin B12 ◽  
Folate Deficiency

scholarly journals The prevalence of low serum levels of Vitamin D, Vitamin B12, folate and ferritin in adolescents: Single center experience

2021 ◽  
Vol 104 (2) ◽  
pp. 003685042110076
Author(s):  
Nazmi Mutlu Karakaş
Keyword(s):  
Vitamin D ◽  
Vitamin B12 ◽  
Medical Records ◽  
Vitamin B12 Deficiency ◽  
Serum Levels ◽  
Folate Deficiency ◽  
Well Child Care ◽  
Single Center Experience ◽  
B12 Deficiency ◽  
Prevalence Of Anemia

Background: In this study, the aim was to evaluate the prevalence of vitamin D, vitamin B12, ferritin, and folate deficiencies in adolescence to clarify the need for early diagnosis and therapy. Methods: The medical records of adolescents between 10 and 18 years of age between 01 September 2018 and 28 February 2019 as healthy with non-specific complaints, or due to well-child care visits, were analyzed retrospectively. Results: A total of 1847/2507 (73.6%) adolescents were included in the study. The prevalence of vitamin D deficiency was 25.7% (n: 178/691). Vitamin B12 deficiency prevalence was 69.2% (n: 753/1088). The prevalence of anemia and ferritin deficiency was 4.8% and 13.26%. The prevalence of folate deficiency was 37.9% (n: 413/1088). VDD prevalence was statistically significantly higher in females than males (F/M:116/62). VB12D prevalence, the number and mean age of females with hemoglobin deficiency, and low ferritin levels was found to be statistically significantly higher in females than males. Conclusions: The prevalence of vitamin D, vitamin B12, folate deficiency and low ferritin levels was found to be high among adolescents. In particular, adolescents admitting with non-specific complaints and for control purposes in big cities must be considered to be at risk for the deficiency of these vitamins and low level of ferritin.

scholarly journals Are we appropriately testing for vitamin B12 and folate deficiency?

2018 ◽  
Vol 3 (1) ◽  
pp. 8-14
Author(s):  
Nawaal Davids ◽  
Mariza Hoffmann ◽  
Nasheen Naidoo ◽  
Thandiwe Manjati ◽  
Rajiv T Erasmus
Keyword(s):  
Vitamin B12 ◽  
Folate Deficiency ◽  
Academic Hospital ◽  
Diagnostic Dilemma ◽  
Vitamin Status ◽  
Retrospective Audit ◽  
Normocytic Anaemia ◽  
Status Assessment ◽  
Cell Volumes ◽  
Metabolite Screening

Background:  The most common reason for assessing vitamin B12 and folate status is a clinical suspicion of deficiency along with the haematological abnormality of macrocytic anaemia.However, there is often a lack of a precise clinical or haematological picture to guide the appropriate investigation of these patients. Normal haemoglobin or mean cell volumes are often found, masking the need for appropriate investigation. When abnormal haematological parameters are found, it is often a sign of advanced deficiency. In this study we investigated whether patients with haematological findings of macrocytosis and/or anaemia are appropriately investigated for vitamin B12 and folate deficiencies and whether clinicians request metabolite screening to assist with the diagnosis.Methods:  This was a retrospective audit of data obtained from the laboratory information system for a six month period at a tertiary academic hospital.  Adult patients with macrocytosis, anaemia or both were selected and laboratory records reviewed to determine whether they were investigated for vitamin B12 and folate deficiency.Results:  Only 16.2% of patients with macrocytic anaemia, 7.8% of patients with isolated macrocytosis and 6.5% of patients with normocytic anaemia were tested for vitamin B12 and/or folate deficiency. Metabolite assays such as homocysteine and methylmalonic acid were not requested as part of a vitamin status assessment. Conclusions:  In our setting, vitamin B12 and folate assessment is a diagnostic dilemma, delaying identification of potentially debilitating disease. Clinicians need to be informed about earlier investigation and of the availability of metabolite screening and their use in establishing early deficiency.

scholarly journals IRON, VITAMIN B12 AND FOLATE DEFICIENCY IN ADOLESCENTS HAVING NUTRITIONAL ANAEMIA

2014 ◽  
Vol 3 (43) ◽  
pp. 10626-10633
Author(s):  
Rajendra Rajendra ◽  
Sudha Sudha ◽  
Sreekanthan Sreekanthan ◽  
Anil Vijayakumar ◽  
Rajendran Rajendran ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Folate Deficiency

scholarly journals Assessment of Deoxyuridine Suppression Test in Diagnosis of Vitamin B12 or Folate Deficiency

BMJ ◽  
1974 ◽  
Vol 3 (5924) ◽  
pp. 148-150 ◽  
Author(s):  
S. N. Wickramasinghe ◽  
J. E. Longland
Keyword(s):  
Vitamin B12 ◽  
Folate Deficiency ◽  
Suppression Test

Prevalence of Vitamin B12 and Folate Deficiency in School Children Residing at High Altitude Regions in India

2017 ◽  
Vol 84 (4) ◽  
pp. 289-293 ◽  
Author(s):  
Aakriti Gupta ◽  
Umesh Kapil ◽  
Lakshmy Ramakrishnan ◽  
Ravindra Mohan Pandey ◽  
Chander Prakash Yadav
Keyword(s):  
Vitamin B12 ◽  
High Altitude ◽  
School Children ◽  
Folate Deficiency

Understanding vitamin B12 and folate deficiency

2020 ◽  
Vol 31 (2) ◽  
pp. 70-74
Author(s):  
Margaret Perry
Keyword(s):  
Vitamin B12 ◽  
Normal Level ◽  
Energy Levels ◽  
Folate Deficiency ◽  
The Body ◽  
Correct Treatment ◽  
Physiological Functions ◽  
Clinically Normal ◽  
Mild Deficiency ◽  
Clinically Significant

Vitamin B12 and folate deficiencies are common and have a big impact on sufferers' lives. Margaret Perry provides an overview of the causes of, and treatments for, these conditions Vitamin B12 and folate are essential for a number of physiological functions in the body. Deficiency of vitamin B12 is relatively common and prevalence increases with age. Folate deficiency is less common, but still clinically significant. Diagnosis can often be problematic as many of the symptoms patients present with are shared with other conditions and can easily be attributed to other causes. Mild deficiency of B12 may cause no symptoms until it has progressed to be more severe. Interpretation of B12 levels is extremely difficult as there is no clinically normal level. Diagnosis can be easily overlooked, but correct treatment has the ability to transform sufferer's lives in terms of improving energy levels and preventing further complications.

scholarly journals Low Vitamin B12 and Bone Loss: A Role for Folate Deficiency

2004 ◽  
Vol 89 (9) ◽  
pp. 4770-4771 ◽  
Author(s):  
Angelo Cagnacci ◽  
Marianna Cannoletta ◽  
Francesco Baldassari ◽  
Annibale Volpe
Keyword(s):  
Bone Loss ◽  
Vitamin B12 ◽  
Folate Deficiency
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