scholarly journals Vaccinating with a COVID-19 Vaccine: Experience of the Tertiary Allergology Center

2022 ◽  
Vol 29 (1) ◽  
pp. 1
Author(s):  
Eglė Žilėnaitė ◽  
Laura Malinauskienė ◽  
Kęstutis Černiauskas ◽  
Linas Griguola ◽  
Kotryna Linauskienė ◽  
...  

Background: Allergic reactions after messenger RNA (mRNA)-based COVID-19 vaccines have been reported but detailed descriptions and further actions are not well characterized. Objective: To describe the symptoms of possible allergic reactions after the mRNA COVID-19 vaccine and outcomes of further vaccination. Methods: We descriptively analyzed data of adult (≥18 years of age) patients, who were sent for vaccination to our outpatient center for the Diagnostics and Treatment of Allergic and Immune diseases. All patients were vaccinated with the Pfizer–BioNTech Comirnaty® vaccine.Results: From January 2021 to July 2021 twenty-two patients were vaccinated in our center. Six patients experienced a reaction after the first Comirnaty® dose in different vaccination centers. The majority of them complained of various types of rashes after the first dose, one case was consistent with anaphylaxis. The latter patient was tested with the skin prick using Pfizer–BioNTech Comirnaty® vaccine and the test was negative. Other sixteen patients were vaccinated in our center from the first dose because of past allergic reactions to other medication or due to concomitant mast cell disorder. All patients were vaccinated without any immediate adverse reactions.Conclusions: None of our patients experienced repeated cutaneous reactions after the second dose. Patients with previous anaphylaxis or mastocytosis also were safely vaccinated.

2001 ◽  
Vol 23 (1) ◽  
pp. 107-117 ◽  
Author(s):  
H. J. Jeong ◽  
H. N. Koo ◽  
N. I. Myung ◽  
M. K. Shin ◽  
J. W. Kim ◽  
...  

2009 ◽  
Vol 47 (11) ◽  
pp. 1096-1106 ◽  
Author(s):  
Rishit Zalawadia ◽  
Chintan Gandhi ◽  
Vaibhav Patel ◽  
Ramchandran Balaraman

2019 ◽  
Vol 12 (3) ◽  
pp. 157-162
Author(s):  
Moussab Damlaj ◽  
Hanadi Ashi ◽  
Fouad Boulos ◽  
Hala Kfoury ◽  
Zaher Chakhachiro

Pharmacy ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 135 ◽  
Author(s):  
Kristy M. Shaeer ◽  
Elias B. Chahine ◽  
Sheeba Varghese Gupta ◽  
Jonathan C. Cho

Macrolides are antimicrobial agents that can be used to treat a variety of infections. Allergic reactions to macrolides occur infrequently but can include minor to severe cutaneous reactions as well as systemic life-threatening reactions such as anaphylaxis. Most reports of allergic reactions occurred in patients without prior exposure to a macrolide. Cross-reactivity among macrolides may occur due to the similarities in their chemical structures; however, some published literature indicates that some patients can tolerate a different macrolide. Most published reports detailed an allergic reaction to erythromycin. Desensitization protocols to clarithromycin and azithromycin have been described in the literature. The purpose of this article is to summarize macrolide-associated allergic reactions reported in published literature. An extensive literature search was conducted to identify publications linking macrolides to hypersensitivity reactions.


Allergy ◽  
1989 ◽  
Vol 44 (8) ◽  
pp. 554-565 ◽  
Author(s):  
H. NOLTE ◽  
P. O. SCHIØTZ ◽  
A. KRUSE ◽  
P. STAHL SKOV

2018 ◽  
Vol 38 (3) ◽  
pp. 455-468 ◽  
Author(s):  
Patrizia Bonadonna ◽  
Luigi Scaffidi
Keyword(s):  

2018 ◽  
Vol 62 ◽  
pp. 244-250 ◽  
Author(s):  
Delu Che ◽  
Liu Rui ◽  
Jiao Cao ◽  
Jue Wang ◽  
Yongjing Zhang ◽  
...  

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Hae Mi Joo ◽  
Eun Hee Hong ◽  
Seong-Jun Cho ◽  
Seon Young Nam ◽  
Ji Young Kim

Abstract The prevalence of allergies has increased over the last four decades. In allergic reactions, mast cells induce a hypersensitive immune response to a substance that is normally harmless. Ionizing radiation has different biological effects depending on the dose and dose rate. In this study, we investigated whether low-dose irradiation before (preventative effect) or after (therapeutic effect) an antigen-antibody reaction has an anti-allergic effect. To test this, we activated rat basophilic leukemia (RBL-2H3) mast cells with anti-2,4-dinitrophenyl IgE (antibody) and 2,4-dinitrophenyl human serum albumin, which served as an antigen. To test for both the potential of a preventative effect and a therapeutic effect, we irradiated mast cells both before and after mast cell activation, and we measured mediator release and signaling pathway activity. Low-dose ionizing radiation suppressed mediator release from RBL-2H3 mast cells activated by the antigen-antibody reaction regardless of when the mast cells were irradiated. These results were due to the suppression of FcεRI expression. Therefore, we suggest that low-dose ionizing radiation has a preventative and therapeutic effect in allergic reactions via the FcεRI-mediated RBL-2H3 mast cell activation system.


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