scholarly journals Potential Benefits of Caffeine Alone or in Combination with Nitrate Supplementation in Blood Pressure Control in the Elderly

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Erico Chagas Caperuto
2016 ◽  
Vol 310 (8) ◽  
pp. R691-R696 ◽  
Author(s):  
Ellen E. Gillis ◽  
Jennifer M. Sasser ◽  
Jennifer C. Sullivan

Endothelin-1 (ET-1) is a potent vasoconstrictor, and dysregulation of the endothelin (ET) system has been implicated in the development of hypertension. Sex differences in the ET system have been identified in ET receptor expression and activation, levels of ET-1, and downstream mediators of the ET system. More specifically, males have greater ET-1/ETA receptor activation, whereas females exhibit greater ETB receptor activation. These differences have been suggested to contribute to the sex differences observed in blood pressure control, with greater ETB receptor activation in females potentially acting as an important pathway contributing to the lower prevalence of hypertension in young females compared with age-matched males. This hypothesis is further supported by studies in pregnancy; the role of the ET system is enhanced during pregnancy, with dysregulation of the ET system resulting in preeclampsia. Further research is necessary to elucidate the relative roles of the ET system in blood pressure control in both sexes and to further explore the potential benefits of pharmacological ET blockade in women.


2007 ◽  
Vol 78 (1) ◽  
pp. 108-114 ◽  
Author(s):  
Masafumi Katakura ◽  
Motoji Naka ◽  
Teruki Kondo ◽  
Mitsuhisa Komatsu ◽  
Keishi Yamauchi ◽  
...  

Author(s):  
Graziano Onder ◽  
Giovanni Gambassi ◽  
Antonio Sgadari ◽  
Jeff D. Williamson ◽  
Matteo Cesari ◽  
...  

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
Z Bargaoui ◽  
K Mzoughi ◽  
S Labbene ◽  
I Zairi ◽  
S Kraiem ◽  
...  

Abstract Funding Acknowledgements Type of funding sources: None. Background Hypertension is a major cardiovascular risk factor, responsible for significant morbidity and mortality. Despite therapeutic progress, blood pressure control remains insufficient. Purpose The aim of our study was to identify the factors associated with poor blood pressure control in the elderly. Methods This was a descriptive study with a prospective data collection including 101 hypertensive treated subjects, aged 65 years and over, followed on outpatient basis between November and December 2019 at the cardiology consultation either at the Habib Thameur hospital or at the Materi hospital. Results Median age was 73 and sex ratio 0.57. The major cardiovascular risk factor was diabetes in 60.4% of cases, followed by dyslipidaemia 48.5% and smoking 40.6%. A history of coronary syndrome was present in 36.6% of cases, followed by atrial fibrillation in 19.8% and 12.9% had a history of ischemic stroke. Thirty-three percent realized regular physical activity and 31% had a high-sodium diet. Four percent of our patients were completely dependent. Among our patients aged 80 and over, 68.2% were frail. The prevalence of poor blood pressure control was 59%. Adherence to treatment was satisfactory in 75.2% of cases. Twelve percent of patients had information about their condition and 89% knew the dosage and schedule for their medication. In multivariate analysis, the factors associated with poor blood pressure control were: non-compliance with treatment (adjusted OR = 0.19; p = 0.013), frailty (adjusted OR = 7.194; p = 0.004), the number of antihypertensive tablets (Adjusted OR = 0.382; p = 0.008), non-use of thiazide diuretics (adjusted OR = 25.903; p = 0.001) and the patient"s lack of knowledge of antihypertensive treatment (adjusted OR = 0.56; p = 0.008). Conclusion Detection of the risk of non-compliance, the use of thiazide diuretics, reducing the number of antihypertensive tablets, screening for frailty and informing the patient about his treatment are necessary to improve blood pressure control in the elderly.


Sign in / Sign up

Export Citation Format

Share Document