scholarly journals Inhibition of multiple forms of carbonic anhydrases of spinach chloroplasts by Cu ions

2018 ◽  
pp. 94-101 ◽  
Author(s):  
A.V. Polishchuk ◽  
◽  
A.V. Semenikhin ◽  
N.M. Topchyi ◽  
E.K. Zolotareva ◽  
...  
Keyword(s):  
Carbonic Anhydrases ◽  
Multiple Forms ◽  
Spinach Chloroplasts ◽  
Cu Ions

scholarly journals The influence of Cd2+ ions on the activity of stromal carbonic anhydrases of spinach chloroplasts

2019 ◽  
Vol 51 (2) ◽  
pp. 172-182 ◽  
Author(s):  
N.M. Topchiy ◽  
◽  
O.V. Polishchuk ◽  
E.K. Zolotareva ◽  
S.K. Sytnyk ◽  
...  
Keyword(s):  
Carbonic Anhydrases ◽  
Spinach Chloroplasts

Identifying suboptimalities with factorial model comparison

2018 ◽  
Vol 41 ◽  
Author(s):  
Wei Ji Ma
Keyword(s):  
Experimental Design ◽  
Model Comparison ◽  
Process Models ◽  
Multiple Forms ◽  
Factorial Experimental Design ◽  
Factorial Model ◽  
Multiple Components ◽  
The Many

AbstractGiven the many types of suboptimality in perception, I ask how one should test for multiple forms of suboptimality at the same time – or, more generally, how one should compare process models that can differ in any or all of the multiple components. In analogy to factorial experimental design, I advocate for factorial model comparison.

Toward a Theory of Intellectual Entertainment

2011 ◽  
Vol 23 (1) ◽  
pp. 52-59 ◽  
Author(s):  
José I. Latorre ◽  
María T. Soto-Sanfiel
Keyword(s):  
Scientific Discovery ◽  
The Self ◽  
Multiple Forms ◽  
Complex Emotions ◽  
Typical Sequence

We reflect on the typical sequence of complex emotions associated with the process of scientific discovery. It is proposed that the same sequence is found to underlie many forms of media entertainment, albeit substantially scaled down. Hence, a distinct theory of intellectual entertainment is put forward. The seemingly timeless presence of multiple forms of intellectual entertainment finds its roots in a positive moral approval of the self of itself.

Neuroimaging of multiple forms of risk

2007 ◽  
Author(s):  
Bethany Weber ◽  
Scott Huettel
Keyword(s):  
Multiple Forms

Melatonin modifies tumor hypoxia and metabolism by inhibiting HIF-1α and energy metabolic pathway in the in vitro and in vivo models of breast cancer

2019 ◽  
Vol 2 (4) ◽  
pp. 83-98 ◽  
Author(s):  
André De Lima Mota ◽  
Bruna Vitorasso Jardim-Perassi ◽  
Tialfi Bergamin De Castro ◽  
Jucimara Colombo ◽  
Nathália Martins Sonehara ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Glucose Metabolism ◽  
Tumor Growth ◽  
Tumor Cells ◽  
Carbonic Anhydrases ◽  
In Vivo Models ◽  
Ca Ix ◽  
Gene And Protein Expression

Breast cancer is the most common cancer among women and has a high mortality rate. Adverse conditions in the tumor microenvironment, such as hypoxia and acidosis, may exert selective pressure on the tumor, selecting subpopulations of tumor cells with advantages for survival in this environment. In this context, therapeutic agents that can modify these conditions, and consequently the intratumoral heterogeneity need to be explored. Melatonin, in addition to its physiological effects, exhibits important anti-tumor actions which may associate with modification of hypoxia and Warburg effect. In this study, we have evaluated the action of melatonin on tumor growth and tumor metabolism by different markers of hypoxia and glucose metabolism (HIF-1α, glucose transporters GLUT1 and GLUT3 and carbonic anhydrases CA-IX and CA-XII) in triple negative breast cancer model. In an in vitro study, gene and protein expressions of these markers were evaluated by quantitative real-time PCR and immunocytochemistry, respectively. The effects of melatonin were also tested in a MDA-MB-231 xenograft animal model. Results showed that melatonin treatment reduced the viability of MDA-MB-231 cells and tumor growth in Balb/c nude mice (p <0.05). The treatment significantly decreased HIF-1α gene and protein expression concomitantly with the expression of GLUT1, GLUT3, CA-IX and CA-XII (p <0.05). These results strongly suggest that melatonin down-regulates HIF-1α expression and regulates glucose metabolism in breast tumor cells, therefore, controlling hypoxia and tumor progression. 

Étranges contagions

2019 ◽  
Vol 58 (2) ◽  
pp. 135-145
Author(s):  
Éric Trudel
Keyword(s):  
Health Hazard ◽  
Multiple Forms ◽  
Source Of Infection

It is by now a mere commonplace to observe that Baudelaire portrayed classical Beauty as a matron of ‘sickening health and virtue’ (New Notes on Edgar Poe). He had, after all, long opened up Aesthetics to the morbid. Few of his readers doubted that his sickly Flowers were, themselves, a dangerous source of infection. Baudelaire's poetics exacerbate and embody a veritable ‘anxiety of perpetual disquiet’ (‘Twilight’). Gazing at the work of Brueghel the elder (‘the Droll’), Baudelaire joyously exclaims that they too ‘seem to spread contagion,’ imparting a pressing practical lesson: ‘often in history […] we find proof of the immense power of contagion’ (‘Some Foreign Caricaturists’). This article examines the multiple forms and uses that contagion takes in Baudelaire's œuvre. It suggests that its transformative agency—vital and viral—is not only a health-hazard, but also an epistemological risk that needs to be contained.

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