scholarly journals Cholesterol and its esters in the bile of rats in tetracyclineinduced hepatosis and under the using of milk phospholipids

2020 ◽  
pp. 93-99
Author(s):  
V.A. Tomchuk ◽  
◽  
V.A. Gryshchenko ◽  
S.P. Veselsky ◽  
Ye.M. Reshetnik ◽  
...  
Keyword(s):  
Liver Damage ◽  
Bile Ducts ◽  
Cholesterol Metabolism ◽  
Cholesterol Esters ◽  
Drug Form ◽  
Drug Induced ◽  
Bile Formation ◽  
Laboratory Rats ◽  
Corrective Effect ◽  
Experimental Drug

The increase of disorders of the cholesterol metabolism and the bile formation determines the need of the search for possible substances correcting the cholesterol metabolism in the liver. It is found that, in laboratory rats with an experimental drug form of steatosis, the excretion of cholesterol and, especially, cholesterol esters to the bile ducts is inhibited, and their ratio in bile is significantly impaired. The use of bioadditive “FLP-MD” made on milk phospholipids has a corrective effect on the concentration of cholesterol and its esters in bile of rats with tetracycline-induced steatosis. This allows us to recommend bioadditive “FLP-MD” made on milk phospholipids to improve the cholesterol metabolism in patients with clinical cases of drug-induced liver damage.

scholarly journals Analysis of common causes of liver damage among children 12 years and younger in Weifang

2021 ◽  
Vol 49 (4) ◽  
pp. 030006052110066
Author(s):  
Qinghong Meng ◽  
Na Li ◽  
Lianmei Yuan ◽  
Xiaona Gao
Keyword(s):  
Liver Damage ◽  
Epstein Barr Virus ◽  
Metabolic Diseases ◽  
Unknown Etiology ◽  
Severe Liver ◽  
Drug Induced ◽  
Barr Virus ◽  
Common Causes ◽  
Severe Liver Damage ◽  
Epstein Barr

Aims To explore the causes of liver damage among children 12 years and younger in Weifang and to provide a theoretical basis for early diagnosis of liver damage in children. Methods Retrospective study of clinical data from pediatric patients (age ≤12 years) with liver damage in diagnosed at Weifang People's Hospital from June 2010 to May 2020. Results A total of 2632 children (1572 boys, 1060 girls) aged ≤12 years were diagnosed with liver damage including infectious liver damage (2100 cases), non-infectious liver damage (446 cases) and liver damage of unknown etiology (86 cases). The most common causes of infectious liver damage were viral infection (1515 cases), Mycoplasma pneumoniae infection (343 cases), and bacterial infection (197 cases). The most common causes of viral liver damage were Epstein–Barr virus, cytomegalovirus, and enterovirus. The most common causes of non-infectious liver damage were drug-induced liver damage, Kawasaki disease, and genetic metabolic diseases. There were 31 cases of severe liver damage. Conclusion There were many causes of liver damage among children in Weifang. Infections, and especially viral infections such as Epstein–Barr virus, were the most common causes of liver damage. Severe liver damage was primarily caused by drugs or poisons.

scholarly journals Choline Supplementation Protects against Liver Damage by Normalizing Cholesterol Metabolism in Pemt/Ldlr Knockout Mice Fed a High-Fat Diet

2013 ◽  
Vol 144 (3) ◽  
pp. 252-257 ◽  
Author(s):  
Ala Al Rajabi ◽  
Gabriela S. F. Castro ◽  
Robin P. da Silva ◽  
Randy C. Nelson ◽  
Aducio Thiesen ◽  
...  
Keyword(s):  
Liver Damage ◽  
Knockout Mice ◽  
High Fat Diet ◽  
Cholesterol Metabolism ◽  
High Fat

Drug-induced acute cholestatic liver damage in a patient with mutation of UGT1A1

2007 ◽  
Vol 4 (7) ◽  
pp. 403-408 ◽  
Author(s):  
Igino Rigato ◽  
Monica Cravatari ◽  
Claudio Avellini ◽  
Euro Ponte ◽  
Saveria Lory Crocè ◽  
...  
Keyword(s):  
Liver Damage ◽  
Drug Induced

scholarly journals BML-257, a small molecule that protects against drug induced liver injury in zebrafish

2022 ◽  
Author(s):  
Urmila Jagtap ◽  
Sandeep Basu ◽  
Lavanya Lokhande ◽  
Nikhil Bharti ◽  
Chetana Sachidanandan
Keyword(s):  
Liver Injury ◽  
Small Molecule ◽  
Liver Damage ◽  
Protective Action ◽  
Damage Model ◽  
Akt Inhibitor ◽  
Drug Induced ◽  
Specific Expression ◽  
Drug Induced Liver Injury ◽  
Chemical Screen

The use of many essential drugs is restricted due to their deleterious effects on the liver. Molecules that can prevent or protect the liver from drug induced liver injury (DILI) would be valuable in such situations. We used hepatocyte-specific expression of bacterial nitroreductase in zebrafish to cause temporally controlled liver damage. This transgenic line was used to run a whole organism based chemical screen in zebrafish larvae. In this screen we identified BML-257, a potent small molecule AKT inhibitor, that protected the liver against metronidazole-induced liver injury. BML-257 also showed potent prophylactic and pro-regenerative activity in this liver damage model. BML-257 also showed remarkable protective action in two independent toxicological models of liver injury caused by acetaminophen and Isoniazid. This suggests that BML-257 may have the potential to protect against multiple kinds of drug induced liver injury.

Experimental Drug-induced Changes in Renal Function and Biodistribution of 99mTc-MDP

1983 ◽  
Vol 18 (5) ◽  
pp. 470-478 ◽  
Author(s):  
J G McAFEE ◽  
A SINGH ◽  
M ROSKOPF ◽  
C RITTER ◽  
B LYONS ◽  
...  
Keyword(s):  
Renal Function ◽  
Drug Induced ◽  
Experimental Drug ◽  
Induced Changes

Drugs and liver damage

2010 ◽  
pp. 2527-2537
Author(s):  
J. Neuberger
Keyword(s):  
Liver Disease ◽  
Liver Injury ◽  
Pulmonary Tuberculosis ◽  
Liver Damage ◽  
Case History ◽  
Genetic Component ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Almost All

Case History—A 22 yr old man, being treated for pulmonary tuberculosis, now presenting with confusion and jaundice. Drug-induced liver injury (DILI) is relatively uncommon but can very rarely be fatal. Almost all patterns of liver disease can be induced by drugs, and some drugs may be associated with more than one type of reaction. Some cases of DILI have a genetic component. Most cases present with jaundice and/or hepatitis....

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